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Gene Review

Chpt1  -  choline phosphotransferase 1

Rattus norvegicus

Synonyms: Cholinephosphotransferase 1, Cpt1, Diacylglycerol cholinephosphotransferase 1
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Disease relevance of Chpt1


High impact information on Chpt1


Biological context of Chpt1

  • The activity of cholinephosphate cytidyltransferase (CCT; key enzyme in PC synthesis), choline phosphotransferase (CPT) and lysolecithin acyltransferase (LAT) were found to increase gradually in the lung towards the end of gestation, reached peak values at term followed by a decrease of activity reaching finally adult levels [7].

Anatomical context of Chpt1


Associations of Chpt1 with chemical compounds


Analytical, diagnostic and therapeutic context of Chpt1


  1. The effect of hyper and hypothyroidism, hypophysectomy and adrenalectomy on phosphatidylethanolamine methyltransferase, phosphatidyldimethyl-ethanolamine methyltransferase and choline phosphotransferase of rat liver microsomes. Cornatzer, W.E., Hoffman, D.R., Haning, J.A. Int. J. Biochem. (1984) [Pubmed]
  2. The final step in the de novo biosynthesis of platelet-activating factor. Properties of a unique CDP-choline:1-alkyl-2-acetyl-sn-glycerol choline-phosphotransferase in microsomes from the renal inner medulla of rats. Woodard, D.S., Lee, T.C., Snyder, F. J. Biol. Chem. (1987) [Pubmed]
  3. The cellular mechanism of glucocorticoid acceleration of fetal lung maturation. Fibroblast-pneumonocyte factor stimulates choline-phosphate cytidylyltransferase activity. Post, M., Barsoumian, A., Smith, B.T. J. Biol. Chem. (1986) [Pubmed]
  4. Mechanisms of hepatic phosphatidylcholine synthesis in adult rat: effects of pregnancy. Burdge, G.C., Hunt, A.N., Postle, A.D. Biochem. J. (1994) [Pubmed]
  5. Factors influencing triacylglycerol synthesis in permeabilized rat hepatocytes. Stals, H.K., Mannaerts, G.P., Declercq, P.E. Biochem. J. (1992) [Pubmed]
  6. Early stimulation of phosphatidylcholine biosynthesis during Wallerian degeneration of rat sciatic nerve. Natarajan, V., Yao, J.K., Dyck, P.J., Schmid, H.H. J. Neurochem. (1982) [Pubmed]
  7. Gestational age dependence of 11 beta-hydroxysteroid dehydrogenase and its relationship to the enzymes of phosphatidylcholine synthesis in lung and liver of fetal rat. Hundertmark, S., Ragosch, V., Schein, B., Bühler, H., Lorenz, U., Fromm, M., Weitzel, H.K. Biochim. Biophys. Acta (1994) [Pubmed]
  8. Distribution of selected phospholipid modifying enzymes in rat brain microsomal subfractions prepared by density gradient zonal rotor centrifugation. Bansal, V.S., Hattori, H., Orihel, D., Kanfer, J.N. Neurochem. Res. (1985) [Pubmed]
  9. Evolutionary comparison of enzyme activities of phosphatidylcholine metabolism in the nervous system of an invertebrate (Loligo pealei), lower vertebrate (Mustelus canis) and the rat. Anfuso, C.D., Sipione, S., Lupo, G., Alberghina, M. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1995) [Pubmed]
  10. Synthesis of molecular species of glycerophospholipids from diglyceride-labeled brain microsomes. Roberti, R., Binaglia, L., Porcellati, G. J. Lipid Res. (1980) [Pubmed]
  11. The effect of dietary carbohydrate and fat on the activities of some enzymes responsible for glycerolipid synthesis in rat liver. Glenny, H.P., Bowley, M., Burditt, S.L., Cooling, J., Pritchard, P.H., Sturton, R.G., Brindley, D.N. Biochem. J. (1978) [Pubmed]
  12. The effect of chronic diabetes, induced by streptozotocin, on the activities of some enzymes of glycerolipid synthesis in rat liver. Whiting, P.H., Bowley, M., Sturton, R.G., Pritchard, P.H., Brindley, D.N., Hawthorne, J.N. Biochem. J. (1977) [Pubmed]
  13. Phosphatidylcholine synthesis-related enzyme activities of bovine brain microvessels exhibit susceptibility to peroxidation. Sipione, S., Lupo, G., Anfuso, C.D., Albanese, V., Alberghina, M. FEBS Lett. (1996) [Pubmed]
  14. Effect of diet on choline phosphotransferase, phosphatidylethanolamine methyltransferase and phosphatidyldimethylethanolamine methyltransferase in liver microsomes. Hoffman, D.R., Uthus, E.O., Cornatzer, W.E. Lipids (1980) [Pubmed]
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