The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

THBS1  -  thrombospondin 1

Gallus gallus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on THBS1


Biological context of THBS1


Anatomical context of THBS1


Associations of THBS1 with chemical compounds

  • The pattern of TSP-1 expression in avascular tissues and in the floor plate is consistent with possible roles for this glycoprotein in regulating angiogenesis and establishing morphogenetic gradients [3].
  • Many conserved domains have been identified, including 27 thrombospondin type 1 repeats, 13 low-density lipoprotein receptor type A domains, one EMI domain (a cysteine-rich domain of extracellular proteins), three von Willebrand factor type D domains, and one cystine knot C-terminal domain [7].

Other interactions of THBS1


  1. Vitronectin and thrombospondin promote retinal neurite outgrowth: developmental regulation and role of integrins. Neugebauer, K.M., Emmett, C.J., Venstrom, K.A., Reichardt, L.F. Neuron (1991) [Pubmed]
  2. Substance P responsiveness of smooth muscle cells is regulated by the integrin ligand, thrombospondin. Dahm, L.M., Bowers, C.W. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. In situ localization of thrombospondin-1 and thrombospondin-3 transcripts in the avian embryo. Tucker, R.P., Hagios, C., Chiquet-Ehrismann, R., Lawler, J. Dev. Dyn. (1997) [Pubmed]
  4. Thrombospondin-4 is expressed by early osteogenic tissues in the chick embryo. Tucker, R.P., Adams, J.C., Lawler, J. Dev. Dyn. (1995) [Pubmed]
  5. Molecular characterisation of EmTFP250: a novel member of the TRAP protein family in Eimeria maxima. Witcombe, D.M., Belli, S.I., Wallach, M.G., Smith, N.C. Int. J. Parasitol. (2003) [Pubmed]
  6. Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1. Chandrasekaran, L., He, C.Z., Al-Barazi, H., Krutzsch, H.C., Iruela-Arispe, M.L., Roberts, D.D. Mol. Biol. Cell (2000) [Pubmed]
  7. Molecular cloning and early expression of chick embryo SCO-spondin. Didier, R., Meiniel, O., Meiniel, A. Cell Tissue Res. (2007) [Pubmed]
  8. Survival and process regrowth of purified chick retinal ganglion cells cultured in a growth factor lacking medium at low density. Modulation by extracellular matrix proteins. Brocco, M.A., Panzetta, P. Brain Res. Dev. Brain Res. (1999) [Pubmed]
WikiGenes - Universities