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Gene Review

CRABP1  -  cellular retinoic acid binding protein 1

Gallus gallus

Synonyms: CRABP-I, cCRABP-I
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High impact information on CRABP1


Biological context of CRABP1


Anatomical context of CRABP1


Associations of CRABP1 with chemical compounds

  • We propose that CRABP could be reducing the effective concentration of retinoic acid reaching the nucleus to a level appropriate for the differential regulation of gene transcription, providing a spatially modulated morphogenetic gradient of information for digit formation [1].
  • Since retinoyl beta-glucuronide (RAG) contains a free carboxyl group, we studied the interactions of RAG with cellular retinoic acid-binding protein (CRABP) and nuclear receptors of retinoic acid (RARs), the possible mediators of the biological action of retinoic acid (RA) [7].
  • 5. Equilibrium binding studies performed under saturating levels of RA indicated that the retinoid bound to the chick CRABP I with a Kd of 27 nM, a value similar to that reported for the native form of this protein from other species [8].
  • The binding of four of these compounds to chick limb bud and axolotl CRABP was tested in sucrose density gradient assays and then their potencies at inducing limb duplications tested [9].
  • We also found that the growth-modulating toxins colchicine and quisqualate destroyed selectively different subsets of CRABP-containing amacrine cells [10].

Analytical, diagnostic and therapeutic context of CRABP1


  1. Spatial distribution of cellular protein binding to retinoic acid in the chick limb bud. Maden, M., Ong, D.E., Summerbell, D., Chytil, F. Nature (1988) [Pubmed]
  2. The cellular retinoic-acid-binding protein is expressed in tissues associated with retinoic-acid-induced malformations. Vaessen, M.J., Meijers, J.H., Bootsma, D., Van Kessel, A.G. Development (1990) [Pubmed]
  3. Cloning and sequencing of the CRABP-I locus from chicken and pufferfish: analysis of the promoter regions in transgenic mice. Kleinjan, D.A., Dekker, S., Guy, J.A., Grosveld, F.G. Transgenic Res. (1998) [Pubmed]
  4. The role of retinoid-binding proteins in the generation of pattern in the developing limb, the regenerating limb and the nervous system. Maden, M., Ong, D.E., Summerbell, D., Chytil, F. Development (1989) [Pubmed]
  5. The development of interneurons in the chick embryo spinal cord following in vivo treatment with retinoic acid. Shiga, T., Gaur, V.P., Yamaguchi, K., Oppenheim, R.W. J. Comp. Neurol. (1995) [Pubmed]
  6. Demonstration of cellular retinoic acid binding protein (CRABP) in chick embryo tendon cells and effects of retinoids on collagen synthesis in tendon and sterna. Oikarinen, A.I., Oikarinen, H., Uitto, J. Biochem. Pharmacol. (1986) [Pubmed]
  7. Retinoyl beta-glucuronide: lack of binding to receptor proteins of retinoic acid as related to biological activity. Sani, B.P., Barua, A.B., Hill, D.L., Shih, T.W., Olson, J.A. Biochem. Pharmacol. (1992) [Pubmed]
  8. Characterization of cellular retinoic acid-binding protein I from chick embryo and its ligand binding properties. Venepally, P., Reddy, L.G., Sani, B.P. Arch. Biochem. Biophys. (1996) [Pubmed]
  9. The respecification of limb pattern by new synthetic retinoids and their interaction with cellular retinoic acid-binding protein. Maden, M., Summerbell, D., Maignan, J., Darmon, M., Shroot, B. Differentiation (1991) [Pubmed]
  10. Localization of retinoid binding proteins, retinoid receptors, and retinaldehyde dehydrogenase in the chick eye. Fischer, A.J., Wallman, J., Mertz, J.R., Stell, W.K. J. Neurocytol. (1999) [Pubmed]
  11. Retinoic acid receptor in the chick limb buds in the early developmental stages. Momoi, T., Kumagai, H., Momoi, M. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  12. Distribution of cellular retinoic acid-binding proteins I and II in the chick embryo and their relationship to teratogenesis. Maden, M. Teratology (1994) [Pubmed]
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