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Gene Review

KHK  -  ketohexokinase (fructokinase)

Homo sapiens

Synonyms: Hepatic fructokinase, Ketohexokinase
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Analytical, diagnostic and therapeutic context of KHK


  1. The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma. Hwa, J.S., Kim, H.J., Goo, B.M., Park, H.J., Kim, C.W., Chung, K.H., Park, H.C., Chang, S.H., Kim, Y.W., Kim, D.R., Cho, G.J., Choi, W.S., Kang, K.R. Proteomics (2006) [Pubmed]
  2. Molecular basis of essential fructosuria: molecular cloning and mutational analysis of human ketohexokinase (fructokinase). Bonthron, D.T., Brady, N., Donaldson, I.A., Steinmann, B. Hum. Mol. Genet. (1994) [Pubmed]
  3. Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria. Asipu, A., Hayward, B.E., O'Reilly, J., Bonthron, D.T. Diabetes (2003) [Pubmed]
  4. Structure, chromosomal localization, and promoter analysis of the human elastin microfibril interfase located proteIN (EMILIN) gene. Doliana, R., Canton, A., Bucciotti, F., Mongiat, M., Bonaldo, P., Colombatti, A. J. Biol. Chem. (2000) [Pubmed]
  5. The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol. Bais, R., James, H.M., Rofe, A.M., Conyers, R.A. Biochem. J. (1985) [Pubmed]
  6. Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of chromosome 2p23. Hayward, B.E., Fantes, J.A., Warner, J.P., Intody, S., Leek, J.P., Markham, A.F., Bonthron, D.T. Mamm. Genome (1996) [Pubmed]
  7. Structure and alternative splicing of the ketohexokinase gene. Hayward, B.E., Bonthron, D.T. Eur. J. Biochem. (1998) [Pubmed]
  8. Expression, purification and preliminary crystallographic studies of human ketohexokinase. Kozak, M., Hayward, B., Borek, D., Bonthron, D.T., Jaskólski, M. Acta Crystallogr. D Biol. Crystallogr. (2001) [Pubmed]
  9. The EMILIN protein family. Colombatti, A., Doliana, R., Bot, S., Canton, A., Mongiat, M., Mungiguerra, G., Paron-Cilli, S., Spessotto, P. Matrix Biol. (2000) [Pubmed]
  10. Enzymes of fructose metabolism in human kidney. Heinz, F., Schlegel, F., Krause, P.H. Enzyme (1975) [Pubmed]
  11. Investigations of the enzymes involved in the fructose breakdown in the cattle lens. Ohrloff, C., Zierz, S., Hockwin, O. Ophthalmic Res. (1982) [Pubmed]
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