Disease relevance of SP1

• Of the markers tested here, consistent reactivity for tumor tissue was noted only for antibody probes reactive to muscle actin (HHF35, alpha sm-1) or to procollagen type I (SP1. D8); for any given tumor, whether induced by v-src DNA or by Rous sarcoma virus, each of these markers was found only in a subpopulation of tumor cells [1].
• Decreased Chicken Ovalbumin Upstream Promoter Transcription Factor II Expression in Tamoxifen-Resistant Breast Cancer Cells [2].

High impact information on SP1

• SP3/SP1 transcription activity regulates specific expression of collagen type X in hypertrophic chondrocytes [3].
• The presumptive promoter and 5'-flanking regions contain an E2 box and consensus binding sites for SP1, for the S8 homeodomain protein, and for two zinc finger clusters within the myeloid progenitor transcription factor, MZF1 [4].
• Positive regulatory elements active in both cell types included an Ng-CAM proximal promoter with SP1 and cAMP response element motifs extending 447 base pairs upstream of a single RNA start site and a region within the first exon corresponding to 5'-untranslated sequences [5].
• Potential binding sites for the transcription factors SP1, AP1 and AP2, are present upstream from the transcription start point [6].
• The sequence of the 5' flanking region contains two SP1-binding sites and a high G+C content suggestive of a housekeeping gene [7].

Biological context of SP1

• The major HD3 protein-binding activity binds to a site (site V) 200 bp upstream from the 'cap' site but, after further fractionation, a second distinct binding activity is detected to a site (site VIII) which contains both the 'CAAT' and 'SP1-binding' consensus sequences [8].
• Transcription factor cCP2 controls gene expression in chicken embryonic stem cells [9].

Anatomical context of SP1

• Transcription factor Ets-1 regulates fibroblast growth factor-1-mediated angiogenesis in vivo: role of Ets-1 in the regulation of the PI3K/AKT/MMP-1 pathway [10].

Other interactions of SP1

• In the present study, we examined the role of SP3/SP1 transcription factors in the regulation of the Col10a1 promoter [3].

Analytical, diagnostic and therapeutic context of SP1

• The SP3/SP1 ratio is higher in hypertrophic versus non-hypertrophic chondrocytes, due to the significant decrease in SP1 in hypertrophic cells detected by real-time PCR and Western blot analyses [3].
• One dozen eggs were collected and analyzed from each of five different brands from hens fed a diet free of animal fat (SP1), certified organic free-range brown eggs (SP2), uncaged unmedicated brown eggs (SP3), cage-free vegetarian diet brown eggs (SP4), or naturally nested uncaged (SP5) [11].

References