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MMP1  -  matrix metallopeptidase 1 (interstitial...

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Disease relevance of MMP1


Psychiatry related information on MMP1

  • The validation of the chamber as in vitro system for the analysis of compound diffusibility and affinity to cartilage was performed using membrane slices of fresh bovine cartilage and a hydroxamic acid derivative (RS-130830) known as matrix metalloproteinase inhibitor (MMPI) [6].

High impact information on MMP1


Biological context of MMP1


Anatomical context of MMP1

  • The localization of proteins for MMP-1, MMP-14, and TIMP-2 showed a similar trend with strong staining intensity in cytoplasm of mammary duct and alveolar epithelial cells during pubertal mammogenesis and late involution [17].
  • Samples were collected at 0, 6, 12, 18, 24, and 48 h (corpora lutea) after GnRH injection (n = 5-6 per time point) and amounts of MMP-1 and MMP-13 mRNA and protein determined using dot blot or semiquantitative RT-PCR and Western blot analyses [14].
  • Bovine primary chondrocyte culture in synthetic matrix metalloproteinase-sensitive poly(ethylene glycol)-based hydrogels as a scaffold for cartilage repair [18].
  • Whole bovine skeletal muscle showed multiple MMP activities on gelatin zymography and also expressed mRNA encoding MMP-1, -2, -9, -14, and -16, tissue inhibitors of metalloproteinase (TIMP)-1, -2, and -3 and plasminogen activator and its receptor [19].
  • Breakdown of proteoglycans from the cartilage matrix was determined by loss of red staining in Safranin O-stained knee joint sections, and matrix metalloproteinase (MMP)-mediated aggrecan degradation was determined by immunolocalization using anti-VDIPEN antibodies [20].

Associations of MMP1 with chemical compounds


Regulatory relationships of MMP1

  • Overexpression of a secretory form of FGF-1 promotes MMP-1-mediated endothelial cell migration [25].
  • These results suggest that IL-4 is able to specifically block cartilage collagen resorption by down-regulating the production of collagenase (MMP-1) and up-regulating TIMP-1 by chondrocytes within the cartilage [26].
  • Among these MMPs, membrane-type MMP-1 (MT1-MMP) is an important molecule that can trigger the invasion of tumor cells by activating MMP-2 on their plasma membrane [27].

Other interactions of MMP1


Analytical, diagnostic and therapeutic context of MMP1


  1. Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage. Little, C.B., Hughes, C.E., Curtis, C.L., Jones, S.A., Caterson, B., Flannery, C.R. Arthritis Rheum. (2002) [Pubmed]
  2. Effect of hypoxia and reoxygenation on gene expression and response to interleukin-1 in cultured articular chondrocytes. Martin, G., Andriamanalijaona, R., Grässel, S., Dreier, R., Mathy-Hartert, M., Bogdanowicz, P., Boumédiene, K., Henrotin, Y., Bruckner, P., Pujol, J.P. Arthritis Rheum. (2004) [Pubmed]
  3. Synthesis and structure-activity relationship of alpha-sulfonylhydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis. Aranapakam, V., Grosu, G.T., Davis, J.M., Hu, B., Ellingboe, J., Baker, J.L., Skotnicki, J.S., Zask, A., DiJoseph, J.F., Sung, A., Sharr, M.A., Killar, L.M., Walter, T., Jin, G., Cowling, R. J. Med. Chem. (2003) [Pubmed]
  4. The relative contribution of cysteine proteinases and matrix metalloproteinases to the resorption process in osteoclasts derived from long bone and scapula. Shorey, S., Heersche, J.N., Manolson, M.F. Bone (2004) [Pubmed]
  5. Increase in milk metalloproteinase activity and vascular permeability in bovine endotoxin-induced and naturally occurring Escherichia coli mastitis. Raulo, S.M., Sorsa, T., Tervahartiala, T., Latvanen, T., Pirilä, E., Hirvonen, J., Maisi, P. Vet. Immunol. Immunopathol. (2002) [Pubmed]
  6. Validation of a diffusion chamber as in vitro system for the analysis of compound diffusibility through cartilage tissue. Kreiselmeier, A., Ulmer, W., Stöve, J., Wieland, H.A., Gerwin, N., Bartnik, E., Schudok, M., Heute, S., Breitenfelder, M., Scharf, H.P., Schwarz, M.L. Biomed. Pharmacother. (2005) [Pubmed]
  7. Matrix metalloproteinase 13 mediates nitric oxide activation of endothelial cell migration. López-Rivera, E., Lizarbe, T.R., Martínez-Moreno, M., López-Novoa, J.M., Rodríguez-Barbero, A., Rodrigo, J., Fernández, A.P., Alvarez-Barrientos, A., Lamas, S., Zaragoza, C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  8. Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes. Steenvoorden, M.M., Huizinga, T.W., Verzijl, N., Bank, R.A., Ronday, H.K., Luning, H.A., Lafeber, F.P., Toes, R.E., DeGroot, J. Arthritis Rheum. (2006) [Pubmed]
  9. Cleavage of fibromodulin in cartilage explants involves removal of the N-terminal tyrosine sulfate-rich region by proteolysis at a site that is sensitive to matrix metalloproteinase-13. Heathfield, T.F., Onnerfjord, P., Dahlberg, L., Heinegård, D. J. Biol. Chem. (2004) [Pubmed]
  10. Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor. Pufe, T., Lemke, A., Kurz, B., Petersen, W., Tillmann, B., Grodzinsky, A.J., Mentlein, R. Am. J. Pathol. (2004) [Pubmed]
  11. Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury. DiMicco, M.A., Patwari, P., Siparsky, P.N., Kumar, S., Pratta, M.A., Lark, M.W., Kim, Y.J., Grodzinsky, A.J. Arthritis Rheum. (2004) [Pubmed]
  12. Retinoids and TIMP1 prevent radiation-induced apoptosis of capillary endothelial cells. Vorotnikova, E., Tries, M., Braunhut, S. Radiat. Res. (2004) [Pubmed]
  13. Linkage mapping of MMP1 to cattle chromosome 15. Christison, K.M., Schmutz, S.M., Berryere, T.G., Buchanan, F.C. Anim. Genet. (2001) [Pubmed]
  14. Gonadotropin surge-induced differential upregulation of collagenase-1 (MMP-1) and collagenase-3 (MMP-13) mRNA and protein in bovine preovulatory follicles. Bakke, L.J., Li, Q., Cassar, C.A., Dow, M.P., Pursley, J.R., Smith, G.W. Biol. Reprod. (2004) [Pubmed]
  15. Unexpected crucial role of residue 272 in substrate specificity of fibroblast collagenase. Tsukada, H., Pourmotabbed, T. J. Biol. Chem. (2002) [Pubmed]
  16. Identification of structural elements important for matrix metalloproteinase type V collagenolytic activity as revealed by chimeric enzymes. Role of fibronectin-like domain and active site of gelatinase B. O'Farrell, T.J., Pourmotabbed, T. J. Biol. Chem. (2000) [Pubmed]
  17. Expression and localization of extracellular matrix-degrading proteinases and their inhibitors in the bovine mammary gland during development, function, and involution. Rabot, A., Sinowatz, F., Berisha, B., Meyer, H.H., Schams, D. J. Dairy Sci. (2007) [Pubmed]
  18. Bovine primary chondrocyte culture in synthetic matrix metalloproteinase-sensitive poly(ethylene glycol)-based hydrogels as a scaffold for cartilage repair. Park, Y., Lutolf, M.P., Hubbell, J.A., Hunziker, E.B., Wong, M. Tissue engineering. (2004) [Pubmed]
  19. Coordinate expression of matrix-degrading proteinases and their activators and inhibitors in bovine skeletal muscle. Balcerzak, D., Querengesser, L., Dixon, W.T., Baracos, V.E. J. Anim. Sci. (2001) [Pubmed]
  20. Role of Fc receptor gamma chain in inflammation and cartilage damage during experimental antigen-induced arthritis. van Lent, P.L., van Vuuren, A.J., Blom, A.B., Holthuysen, A.E., van de Putte, L.B., van de Winkel, J.G., van den Berg, W.B. Arthritis Rheum. (2000) [Pubmed]
  21. Retinoic acid-induced type II collagen degradation does not correlate with matrix metalloproteinase activity in cartilage explant cultures. Price, J.S., Wang-Weigand, S., Bohne, R., Kozaci, L.D., Hollander, A.P. Arthritis Rheum. (1999) [Pubmed]
  22. Proline-rich tyrosine kinase 2 and Src kinase signaling transduce monosodium urate crystal-induced nitric oxide production and matrix metalloproteinase 3 expression in chondrocytes. Liu, R., Lioté, F., Rose, D.M., Merz, D., Terkeltaub, R. Arthritis Rheum. (2004) [Pubmed]
  23. Mechanisms of extracellularly regulated kinases 1/2 activation in adrenal glomerulosa cells by lysophosphatidic acid and epidermal growth factor. Shah, B.H., Baukal, A.J., Shah, F.B., Catt, K.J. Mol. Endocrinol. (2005) [Pubmed]
  24. Matrix metalloproteinase and alphavbeta3 integrin-dependent vascular smooth muscle cell invasion through a type I collagen lattice. Kanda, S., Kuzuya, M., Ramos, M.A., Koike, T., Yoshino, K., Ikeda, S., Iguchi, A. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  25. Overexpression of a secretory form of FGF-1 promotes MMP-1-mediated endothelial cell migration. Partridge, C.R., Hawker, J.R., Forough, R. J. Cell. Biochem. (2000) [Pubmed]
  26. Interleukin-4 blocks the release of collagen fragments from bovine nasal cartilage treated with cytokines. Cawston, T.E., Ellis, A.J., Bigg, H., Curry, V., Lean, E., Ward, D. Biochim. Biophys. Acta (1996) [Pubmed]
  27. Induction of membrane-type matrix metalloproteinase-1 stimulates angiogenic activities of bovine aortic endothelial cells. Jeong, J.W., Cha, H.J., Yu, D.Y., Seiki, M., Kim, K.W. Angiogenesis (1999) [Pubmed]
  28. Bovine membrane-type 1 matrix metalloproteinase: molecular cloning and expression in the corpus luteum. Zhang, B., Yan, L., Moses, M.A., Tsang, P.C. Biol. Reprod. (2002) [Pubmed]
  29. Induction of CD44 and MMP expression by hyaluronidase treatment of articular chondrocytes. Ohno-Nakahara, M., Honda, K., Tanimoto, K., Tanaka, N., Doi, T., Suzuki, A., Yoneno, K., Nakatani, Y., Ueki, M., Ohno, S., Knudson, W., Knudson, C.B., Tanne, K. J. Biochem. (2004) [Pubmed]
  30. Activation of recombinant bovine matrix metalloproteinase-20 and its hydrolysis of two amelogenin oligopeptides. Li, W., Machule, D., Gao, C., DenBesten, P.K. Eur. J. Oral Sci. (1999) [Pubmed]
  31. Shedding of membrane type matrix metalloproteinase 5 by a furin-type convertase: a potential mechanism for down-regulation. Wang, X., Pei, D. J. Biol. Chem. (2001) [Pubmed]
  32. Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes. Nebl, T., Pestonjamasp, K.N., Leszyk, J.D., Crowley, J.L., Oh, S.W., Luna, E.J. J. Biol. Chem. (2002) [Pubmed]
  33. The effect of mechanical strain on matrix metalloproteinase production by bovine trabecular meshwork cells. WuDunn, D. Curr. Eye Res. (2001) [Pubmed]
  34. Effects of bunazosin hydrochloride on ciliary muscle constriction and matrix metalloproteinase activities. Akaishi, T., Takagi, Y., Matsugi, T., Ishida, N., Hara, H., Kashiwagi, K. Journal of glaucoma. (2004) [Pubmed]
  35. Photodynamic therapy generates a matrix barrier to invasive vascular cell migration. Overhaus, M., Heckenkamp, J., Kossodo, S., Leszczynski, D., LaMuraglia, G.M. Circ. Res. (2000) [Pubmed]
  36. Cleavage of type XI collagen fibers by gelatinase and by extracts of osteoarthritic canine cartilage. Smith, G.N., Hasty, K.A., Yu, L.P., Lamberson, K.S., Mickler, E.A., Brandt, K.D. Matrix (1991) [Pubmed]
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