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HTR2A  -  5-hydroxytryptamine (serotonin) receptor...

Sus scrofa

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Disease relevance of HTR2A


High impact information on HTR2A


Biological context of HTR2A


Anatomical context of HTR2A


Associations of HTR2A with chemical compounds


Other interactions of HTR2A


Analytical, diagnostic and therapeutic context of HTR2A

  • The availability of 5-HT2A receptor selective cDNA clones from brain of both guinea pig and rat permitted molecular probes to be designed and PCR amplification studies initiated to identify and quantify 5-HT2A receptor specific mRNA in these tissues [10].


  1. Lack of prophylactic or therapeutic efficacy of 5-HT2A receptor antagonists in halothane-induced porcine malignant hyperthermia. Löscher, W., Gerdes, C., Richter, A. Naunyn Schmiedebergs Arch. Pharmacol. (1994) [Pubmed]
  2. In vivo electrophysiological characterization of 5-HT receptors in the guinea pig head of caudate nucleus and orbitofrontal cortex. el Mansari, M., Blier, P. Neuropharmacology (1997) [Pubmed]
  3. Neomycin selectively inhibits 5-hydroxytryptamine-induced contraction in the guinea pig trachea. Cox, D.A., Watts, S.W., Cohen, M.L. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  4. Contractile serotonin-2A receptor signal transduction in guinea pig trachea: importance of protein kinase C and extracellular and intracellular calcium but not phosphoinositide hydrolysis. Watts, S.W., Cox, D.A., Johnson, B.G., Schoepp, D.D., Cohen, M.L. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  5. Autoradiographic comparison of [125I]LSD-labeled 5-HT2A receptor distribution in rat and guinea pig brain. Watts, S.W., Gackenheimer, S.L., Gehlert, D.R., Cohen, M.L. Neurochem. Int. (1994) [Pubmed]
  6. 5-HT2A receptor antagonist properties of cyamemazine in rat and guinea pig smooth muscle. Alvarez-Guerra, M., Hameg, A., Bayle, F., Dib, M., Garay, R.P. Eur. J. Pharmacol. (2002) [Pubmed]
  7. Effects of sarpogrelate, a novel 5-HT2 antagonist, on 5-HT-induced endothelium-dependent relaxations in porcine coronary artery. Rashid, M., Nakazawa, M., Nagatomo, T. Jpn. J. Pharmacol. (2002) [Pubmed]
  8. Interaction of the beta adrenergic receptor antagonist bucindolol with serotonergic receptors. Watts, S.W., Fink, G.D., Silver, P.J., Cushing, D.J. J. Cardiovasc. Pharmacol. (2000) [Pubmed]
  9. Influence of 5-hydroxytryptamine on aortic valve competence in vitro. Chester, A.H., Misfeld, M., Sievers, H.H., Yacoub, M.H. J. Heart Valve Dis. (2001) [Pubmed]
  10. Relationship between 5-HT2A receptor mRNA density and contractility in trachea and aorta from guinea pig and rat. Baez, M., Mercurio, L., Schenck, K., Cohen, M.L. Life Sci. (1994) [Pubmed]
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