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Gene Review

LIMS1  -  LIM and senescent cell antigen-like domains 1

Homo sapiens

Synonyms: LIM and senescent cell antigen-like-containing domain protein 1, PINCH, PINCH-1, PINCH1, Particularly interesting new Cys-His protein 1, ...
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Disease relevance of LIMS1

  • Surgical Pearl: Pinch-punch excisions for scrotal calcinosis [1].
  • METHODS AND RESULTS: Pinch samples of the terminal ileum, proximal and distal colon were taken from a healthy 35-year-old, and a 68-year-old subject with mild diverticulosis [2].
  • STUDY DESIGN: Pinch motion between the thumb and the index finger in myelopathy hand was analyzed using micro-reflective markers and the VICON system [3].

High impact information on LIMS1


Biological context of LIMS1


Anatomical context of LIMS1

  • This study reviews our experience in less invasive mitral valve surgery (LIMS) during that time [10].

Regulatory relationships of LIMS1

  • Treatment with an ILK inhibitor or disruption of the ILK/PINCH-1 interaction by overexpressing a dominant-negative N-terminal ankyrin domain of ILK resulted in reduced fibronectin deposition, indicating that the ability of PINCH-1 to stimulate EMT is ILK-dependent [11].

Other interactions of LIMS1

  • These results identify Rac as a downstream target of PINCH-1, ILK, and parvin [12].
  • The Pinch Test, and with it, the Bonney Test, are analysed with reference to the 1st and 2nd closure mechanisms presented in the Theory of Female Urinary Incontinence described earlier in this issue [13].

Analytical, diagnostic and therapeutic context of LIMS1

  • Currently, storage for trials at 277 K is not automated and for imaging the crystallization plates are fed by hand into an imaging system from which the data enter the LIMS [14].
  • The various processes all report electronically to a Laboratory Information Management System (LIMS) to make sure all the parameters of the experiment are recorded in an accessible and 'mineable' form, helping guarantee reproducibility of results [15].
  • SUBJECTS AND METHODS: Fifty normal subjects and Twenty-one patients, (Eleven patients treated with early active and resistive goal directed mobilisation and Ten control group) were assessed for pinch strength and grip strength on Pinch Dynamometer and Jamar Dynamometer and work of hand muscles on Ergograph [16].
  • Rejuvenation may be reached by simple hardware and software modifications, to allow data exchange with modern PC's and LIMS [17].
  • In our laboratory we developed a Laboratory Information Management System (LIMS) controlled workflow architecture, which comprises a robotic DNA extraction- and pipetting-system and a capillary electrophoresis unit [18].


  1. Surgical Pearl: Pinch-punch excisions for scrotal calcinosis. Chang, C.H., Yang, C.H., Hong, H.S. J. Am. Acad. Dermatol. (2004) [Pubmed]
  2. Molecular characterization of the microbial species that colonize human ileal and colonic mucosa by using 16S rDNA sequence analysis. Wang, X., Heazlewood, S.P., Krause, D.O., Florin, T.H. J. Appl. Microbiol. (2003) [Pubmed]
  3. Finger motion analysis of the patients with cervical myelopathy. Sakai, N. Spine. (2005) [Pubmed]
  4. PINCH, N(i)ck and the ILK: network wiring at cell-matrix adhesions. Wu, C. Trends Cell Biol. (2005) [Pubmed]
  5. Molecular dissection of PINCH-1 reveals a mechanism of coupling and uncoupling of cell shape modulation and survival. Xu, Z., Fukuda, T., Li, Y., Zha, X., Qin, J., Wu, C. J. Biol. Chem. (2005) [Pubmed]
  6. PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival. Fukuda, T., Chen, K., Shi, X., Wu, C. J. Biol. Chem. (2003) [Pubmed]
  7. Comprehensive gene expression analysis by transcript profiling. Donson, J., Fang, Y., Espiritu-Santo, G., Xing, W., Salazar, A., Miyamoto, S., Armendarez, V., Volkmuth, W. Plant Mol. Biol. (2002) [Pubmed]
  8. Three-dimensional structure determination of proteins related to human health in their functional context at The Israel Structural Proteomics Center (ISPC). This paper was presented at ICCBM10. Albeck, S., Burstein, Y., Dym, O., Jacobovitch, Y., Levi, N., Meged, R., Michael, Y., Peleg, Y., Prilusky, J., Schreiber, G., Silman, I., Unger, T., Sussman, J.L. Acta Crystallogr. D Biol. Crystallogr. (2005) [Pubmed]
  9. Development of an open source laboratory information management system for 2-D gel electrophoresis-based proteomics workflow. Morisawa, H., Hirota, M., Toda, T. BMC Bioinformatics (2006) [Pubmed]
  10. Five years of less invasive mitral valve surgery: from experimental to routine approach. Onnasch, J.F., Schneider, F., Falk, V., Mierzwa, M., Bucerius, J., Mohr, F.W. The heart surgery forum. (2002) [Pubmed]
  11. PINCH-1 promotes tubular epithelial-to-mesenchymal transition by interacting with integrin-linked kinase. Li, Y., Dai, C., Wu, C., Liu, Y. J. Am. Soc. Nephrol. (2007) [Pubmed]
  12. Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. Zhang, Y., Chen, K., Tu, Y., Wu, C. J. Biol. Chem. (2004) [Pubmed]
  13. Pinch test for diagnosis of stress urinary incontinence. Petros, P.E., Ulmsten, U.I. Acta obstetricia et gynecologica Scandinavica. Supplement. (1990) [Pubmed]
  14. A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization. Walter, T.S., Diprose, J.M., Mayo, C.J., Siebold, C., Pickford, M.G., Carter, L., Sutton, G.C., Berrow, N.S., Brown, J., Berry, I.M., Stewart-Jones, G.B., Grimes, J.M., Stammers, D.K., Esnouf, R.M., Jones, E.Y., Owens, R.J., Stuart, D.I., Harlos, K. Acta Crystallogr. D Biol. Crystallogr. (2005) [Pubmed]
  15. From information management to protein annotation: preparing protein structures for drug discovery. Peat, T., de La Fortelle, E., Culpepper, J., Newman, J. Acta Crystallogr. D Biol. Crystallogr. (2002) [Pubmed]
  16. Effect of early mobilisation on grip strength, pinch strength and work of hand muscles in cases of closed diaphyseal fracture radius-ulna treated with dynamic compression plating. Solanki, P.V., Mulgaonkar, K.P., Rao, S.A. Journal of postgraduate medicine. (2000) [Pubmed]
  17. Rejuvenating old computerized spectrometric instrumentation: discussion of two case histories. Dossi, C., Pozzi, A., Recchia, S., Giussani, B., Dal Santo, V. Annali di chimica. (2004) [Pubmed]
  18. Automation and high through-put for a DNA database laboratory: development of a laboratory information management system. Steinlechner, M., Parson, W. Croat. Med. J. (2001) [Pubmed]
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