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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Calcinosis


Psychiatry related information on Calcinosis


High impact information on Calcinosis


Chemical compound and disease context of Calcinosis


Biological context of Calcinosis

  • Reciprocally tumoral calcinosis (TC) patients are often hyperphosphatemic with inappropriately normal or elevated serum 1,25(OH)2D3 levels and have ectopic and vascular calcifications, a phenotype similar to that of Fgf23 null mice [17].
  • The radiographic similarity between uremic tumoral calcifications and those found in hereditary tumoral calcinosis, a disorder of calcitriol and phosphorus homeostasis, caused us to examine whether abnormalities in vitamin D metabolism were associated with uremic calcinosis as well [18].
  • A relative but specific decrease in the renal hydroxylation to 1,25-dihydroxyvitamin D, i.e. the active hormone, as the disease progresses and calcinosis occurs, is suspected [19].

Anatomical context of Calcinosis


Gene context of Calcinosis

  • OBJECTIVE: The objective of this study was to carry out mutational analysis of LMNA in a patient with a novel syndrome of arthropathy, tendinous calcinosis, and progeroid features [25].
  • These findings suggest that abnormal expression of MGP plays a major role in the pathologic calcification of the twy mouse [26].
  • Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression [27].
  • WS patients develop various forms of arteriosclerosis, particularly atherosclerosis, and medial calcinosis [28].
  • Histological examination revealed intracardiac calcinosis in three cases, and each case showed haemodialysis hypoparathyroidism (intact PTH < 160 pg/ml) [29].

Analytical, diagnostic and therapeutic context of Calcinosis


  1. A 17-kD centromere protein (CENP-A) copurifies with nucleosome core particles and with histones. Palmer, D.K., O'Day, K., Wener, M.H., Andrews, B.S., Margolis, R.L. J. Cell Biol. (1987) [Pubmed]
  2. The concurrence of rheumatoid arthritis and limited systemic sclerosis: clinical and serologic characteristics of an overlap syndrome. Zimmermann, C., Steiner, G., Skriner, K., Hassfeld, W., Petera, P., Smolen, J.S. Arthritis Rheum. (1998) [Pubmed]
  3. FGF23 and disorders of phosphate homeostasis. Yu, X., White, K.E. Cytokine Growth Factor Rev. (2005) [Pubmed]
  4. Autoantibodies to mitochondria in systemic sclerosis. Frequency and characterization using recombinant cloned autoantigen. Fregeau, D.R., Leung, P.S., Coppel, R.L., McNeilage, L.J., Medsger, T.A., Gershwin, M.E. Arthritis Rheum. (1988) [Pubmed]
  5. Distinct transglutaminase 2-independent and transglutaminase 2-dependent pathways mediate articular chondrocyte hypertrophy. Johnson, K.A., van Etten, D., Nanda, N., Graham, R.M., Terkeltaub, R.A. J. Biol. Chem. (2003) [Pubmed]
  6. Cerebral calcinosis and learning disabilities in hypoparathyroidism: a cause and effect or a coincidence? Shuper, A., Zeharia, A., Korenreich, L., Sadeh, M., Mimouni, M. Pediatric neurology. (1995) [Pubmed]
  7. Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis. Topaz, O., Shurman, D.L., Bergman, R., Indelman, M., Ratajczak, P., Mizrachi, M., Khamaysi, Z., Behar, D., Petronius, D., Friedman, V., Zelikovic, I., Raimer, S., Metzker, A., Richard, G., Sprecher, E. Nat. Genet. (2004) [Pubmed]
  8. Hyperphosphatemic tumoral calcinosis: association with elevation of serum 1,25-dihydroxycholecalciferol concentrations. Prince, M.J., Schaeffer, P.C., Goldsmith, R.S., Chausmer, A.B. Ann. Intern. Med. (1982) [Pubmed]
  9. An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Benet-Pagès, A., Orlik, P., Strom, T.M., Lorenz-Depiereux, B. Hum. Mol. Genet. (2005) [Pubmed]
  10. Paradoxically decreased aortic wall stiffness in response to vitamin D3-induced calcinosis. A biphasic analysis of segmental elastic properties in conscious dogs. Cabrera Fischer, E.I., Armentano, R.L., Levenson, J., Barra, J.G., Morales, M.C., Breitbart, G.J., Pichel, R.H., Simon, A. Circ. Res. (1991) [Pubmed]
  11. Bilateral striopallidodentate calcinosis: cerebrospinal fluid, imaging, and electrophysiological studies. Manyam, B.V., Bhatt, M.H., Moore, W.D., Devleschoward, A.B., Anderson, D.R., Calne, D.B. Ann. Neurol. (1992) [Pubmed]
  12. Effect of warfarin sodium therapy on excretion of 4-carboxy-L-glutamic acid in scleroderma, dermatomyositis, and myositis ossificans progressiva. Moore, S.E., Jump, A.A., Smiley, J.D. Arthritis Rheum. (1986) [Pubmed]
  13. Treatment of calcinosis with diltiazem. Palmieri, G.M., Sebes, J.I., Aelion, J.A., Moinuddin, M., Ray, M.W., Wood, G.C., Leventhal, M.R. Arthritis Rheum. (1995) [Pubmed]
  14. Calcium-acidic phospholipid-phosphate complexes in human hydroxyapatite-containing pathologic deposits. Boskey, A.L., Bullough, P.G., Vigorita, V., Di Carlo, E. Am. J. Pathol. (1988) [Pubmed]
  15. Calcification of subcutaneously implanted type I collagen sponges. Effects of formaldehyde and glutaraldehyde pretreatments. Levy, R.J., Schoen, F.J., Sherman, F.S., Nichols, J., Hawley, M.A., Lund, S.A. Am. J. Pathol. (1986) [Pubmed]
  16. Phosphorus excretion in tumoral calcinosis: response to parathyroid hormone and acetazolamide. Lufkin, E.G., Wilson, D.M., Smith, L.H., Bill, N.J., DeLuca, H.F., Dousa, T.P., Knox, F.G. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  17. A novel recessive mutation in fibroblast growth factor-23 causes familial tumoral calcinosis. Larsson, T., Yu, X., Davis, S.I., Draman, M.S., Mooney, S.D., Cullen, M.J., White, K.E. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  18. Uremic tumoral calcinosis: preliminary observations suggesting an association with aberrant vitamin D homeostasis. Quarles, L.D., Murphy, G., Econs, M.J., Martinez, S., Lobaugh, B., Lyles, K.W. Am. J. Kidney Dis. (1991) [Pubmed]
  19. Vitamin D metabolites in generalized scleroderma. Evidence of a normal cutaneous and intestinal supply with vitamin D. Serup, J., Hagdrup, H. Acta Derm. Venereol. (1985) [Pubmed]
  20. Idiopathic calcinosis and vitiligo of the scrotum. Feinstein, A., Kahana, M., Schewach-Millet, M., Levy, A. J. Am. Acad. Dermatol. (1984) [Pubmed]
  21. Childhood systemic lupus erythematosus. Association with pancreatitis, subcutaneous fat necrosis, and calcinosis cutis. Simons-Ling, N., Schachner, L., Penneys, N., Gorman, H., Zillereulo, G., Strauss, J. Archives of dermatology. (1983) [Pubmed]
  22. Beta3 integrin--a promiscuous integrin involved in vascular pathology. Veinot, J.P., Srivatsa, S., Carlson, P. The Canadian journal of cardiology. (1999) [Pubmed]
  23. Inorganic pyrophosphate (PPI) in pathologic calcification of articular cartilage. Johnson, K., Terkeltaub, R. Front. Biosci. (2005) [Pubmed]
  24. Hyaluronic acid grafting mitigates calcification of glutaraldehyde-fixed bovine pericardium. Ohri, R., Hahn, S.K., Hoffman, A.S., Stayton, P.S., Giachelli, C.M. Journal of biomedical materials research. Part A. (2004) [Pubmed]
  25. A homozygous mutation in the lamin A/C gene associated with a novel syndrome of arthropathy, tendinous calcinosis, and progeroid features. Van Esch, H., Agarwal, A.K., Debeer, P., Fryns, J.P., Garg, A. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  26. Gene expression of noncollagenous bone matrix proteins in the limb joints and intervertebral disks of the twy mouse. Ohtsuki, T., Furuya, S., Yamada, T., Nomura, S., Hata, J., Yabe, Y., Hosoda, Y. Calcif. Tissue Int. (1998) [Pubmed]
  27. Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression. Johnson, K., Goding, J., Van Etten, D., Sali, A., Hu, S.I., Farley, D., Krug, H., Hessle, L., Millán, J.L., Terkeltaub, R. J. Bone Miner. Res. (2003) [Pubmed]
  28. Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis. Castro, E., Edland, S.D., Lee, L., Ogburn, C.E., Deeb, S.S., Brown, G., Panduro, A., Riestra, R., Tilvis, R., Louhija, J., Penttinen, R., Erkkola, R., Wang, L., Martin, G.M., Oshima, J. Am. J. Med. Genet. (2000) [Pubmed]
  29. Mobile intracardiac calcinosis: a new risk of thromboembolism in patients with haemodialysed end stage renal disease. Tsuchihashi, K., Nozawa, A., Marusaki, S., Moniwa, N., Oh-numa, Y., Kuno, A., Takagi, S., Takizawa, H., Ura, N., Shimamoto, K. Heart (1999) [Pubmed]
  30. A pilot study of acetic acid iontophoresis and ultrasound in the treatment of systemic sclerosis-related calcinosis. Shetty, S., Moore, T.L., Jackson, S., Brettle, D., Herrick, A.L. Rheumatology (Oxford, England) (2005) [Pubmed]
  31. Gastric mucosal calcinosis. Calcified aluminum phosphate deposits secondary to aluminum-containing antacids or sucralfate therapy in organ transplant patients. Greenson, J.K., Trinidad, S.B., Pfeil, S.A., Brainard, J.A., McBride, P.T., Colijn, H.O., Tesi, R.J., Lucas, J.G. Am. J. Surg. Pathol. (1993) [Pubmed]
  32. Calcinosis cutis following intravenous infusion of calcium gluconate. Millard, T.P., Harris, A.J., MacDonald, D.M. Br. J. Dermatol. (1999) [Pubmed]
  33. Calcinosis cutis following liver transplantation: a complication of intravenous calcium administration. Jucglà, A., Sais, G., Curco, N., Marcoval, J., Moreno, A., Peyri, J. Br. J. Dermatol. (1995) [Pubmed]
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