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Gene Review

UMOD  -  uromodulin

Canis lupus familiaris

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Disease relevance of UMOD

  • In summary our data give evidence that renal tubular cell THP expression may be relevant in kidney diseases since THP is a potent activator of human granulocytes [1].
  • In the present study, we assessed levels of retinol, retinyl esters, retinol-binding protein (RBP) and THP in plasma and urine of dogs with a history of urolithiasis (n = 25) compared with clinically healthy controls (n = 18) [2].
  • OBJECTIVES: To study the role of urinary inhibitors on crystallization-nephrocalcin, Tamm-Horsfall protein (THP), and glycosaminoglycans (GAGs)-in hyperuricosuric nephrolithiasis using Dalmatian dogs, a breed well-known for high levels of uric acid excretion, in an in vivo model [3].

High impact information on UMOD

  • The relative potency was PCE greater than TCP greater than PCP greater than THP greater than PCDEA greater than ketamine [4].
  • Coated COM crystals from male controls contained 3.5-fold more Tamm-Horsfall protein (THP) than SF subjects (P < 0.01) [5].
  • A strong binding of THP to human granulocytes was demonstrated by fluorescence-activated cell sorter analysis [1].
  • Renal tubular epithelial cell mechanisms inducing granulocytic activation and bacterial killing may include tubular cell expression of Tamm-Horsfall protein (THP), a urinary protein that is known to enhance cytokine expression in monocytes [1].
  • Renal tubular cells growing polarized on polycarbonate membranes were used to study apical versus basal THP expression [1].

Biological context of UMOD


Anatomical context of UMOD


Associations of UMOD with chemical compounds

  • During the postcontrast period, SOD significantly attenuated the increase in urinary THP excretion, accompanied by an attenuated increase in renal venous malondialdehyde concentration [7].
  • The use of another contrast medium, iothalamate sodium, similarly increased urinary THP excretion [7].
  • Our data point to the possibility that THP functions as a novel carrier for vitamin A in the urine of canines [8].
  • OBJECTIVE: To determine plasma and urine concentrations of retinol, retinyl esters, retinol-binding protein (RBP), and Tamm-Horsfall protein (THP) in dogs with chronic renal disease (CRD) [10].
  • Excretion of urinary retinol and retinyl esters were tentatively, but not significantly higher in the stone-forming groups, which was accompanied by increased levels of urinary RBP (P < 0.01) and lower excretions in THP (P < 0.01) [2].

Analytical, diagnostic and therapeutic context of UMOD

  • Concentrations of RBP and THP were measured by use of sensitive ELISA systems [10].
  • Sodium dodecyl sulphate-polyacrylamid gel electrophoresis and subsequent Western blot analysis of urine showed the presence of heavy and light chains of immunoglobulin, transferrin, albumin, vitamin D-binding protein, transthyretin and retinol-binding protein (RBP), but no excretion of Tamm-Horsfall protein (THP) [11].
  • The presence of THP, the carrier for vitamin A in canine urine, showed that vitamin A excretion in the urine of dogs is not merely a filtration process but also seems to be a pathway located in the distal part of the nephron [9].


  1. Polarized expression of Tamm-Horsfall protein by renal tubular epithelial cells activates human granulocytes. Kreft, B., Jabs, W.J., Laskay, T., Klinger, M., Solbach, W., Kumar, S., van Zandbergen, G. Infect. Immun. (2002) [Pubmed]
  2. Levels of retinol and retinyl esters in plasma and urine of dogs with urolithiasis. Raila, J., Forterre, S., Schweigert, F.J. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine. (2003) [Pubmed]
  3. Role of urinary inhibitors of crystallization in uric acid nephrolithiasis: Dalmatian dog model. Carvalho, M., Lulich, J.P., Osborne, C.A., Nakagawa, Y. Urology (2003) [Pubmed]
  4. Phencyclidine ("angel dust") analogs and sigma opiate benzomorphans cause cerebral arterial spasm. Altura, B.T., Quirion, R., Pert, C.B., Altura, B.M. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  5. Urinary macromolecular inhibition of crystal adhesion to renal epithelial cells is impaired in male stone formers. Kumar, V., Peña de la Vega, L., Farell, G., Lieske, J.C. Kidney Int. (2005) [Pubmed]
  6. Sequencing and radiation hybrid mapping of canine uromodulin. Cox, M.L., Quignon, P., Galibert, F., Lees, G.E., Murphy, K.E. DNA Seq. (2003) [Pubmed]
  7. Oxygen free radical involvement in urinary Tamm-Horsfall protein excretion after intrarenal injection of contrast medium. Bakris, G.L., Gaber, A.O., Jones, J.D. Radiology. (1990) [Pubmed]
  8. Vitamin A excreted in the urine of canines is associated with a Tamm-Horsfall like protein. Schweigert, F.J., Raila, J., Haebel, S. Vet. Res. (2002) [Pubmed]
  9. Immunochemical localization of megalin, retinol-binding protein and Tamm-Horsfall glycoprotein in the kidneys of dogs. Raila, J., Neumann, U., Schweigert, F.J. Vet. Res. Commun. (2003) [Pubmed]
  10. Effects of chronic renal disease on the transport of vitamin A in plasma and urine of dogs. Raila, J., Forterre, S., Kohn, B., Brunnberg, L., Schweigert, F.J. Am. J. Vet. Res. (2003) [Pubmed]
  11. Renal pathology and urinary protein excretion in a 14-month-old bernese mountain dog with chronic renal failure. Raila, J., Aupperle, H., Raila, G., Schoon, H.A., Schweigert, F.J. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine (2007) [Pubmed]
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