The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Gastrografin     sodium3,5-diacetamido-2,4,6- triiodo-benzoate

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of amidotrizoic acid


High impact information on amidotrizoic acid

  • The glomerular filtration rate, determined by iothalamate clearance, was better maintained in the treated group (average decrease, 1.3 ml per minute per 1.73 m2 of body-surface area per 12 months) than in the placebo group (average decrease, 19.6) [6].
  • In the diabetic group, the glomerular filtration rate (GFR, iothalamate clearance) exceeded the control value by 15% (140 +/- 6 vs. 122 +/- 5 ml/min, P less than 0.01) [7].
  • In order to study the effects of the commonly employed contrast media alone and in combination with bacteria in the mediastinum, various mixtures of barium and meglamine diatrizoate (Gastrografin) with and without flora were instilled in the mediastinum of 29 domestic cats [8].
  • Liver cells were isolated on Ficoll/Hypaque gradients from embryos or fetuses at 6-10 weeks of gestation; 2-20% of the cells expressed CD45 or HLA class I surface antigens and 2-6% expressed CD7 [9].
  • When lymphocytes were enriched from kidney tumors and surrounding tissue by either Ficoll/Hypaque density gradient or immunomagnetic selection with anti-CD3, anti-CD4, or anti-CD8 monoclonal antibodies, it was confirmed that they contained a high percentage of trisomy 7 and trisomy 10 cells [10].

Chemical compound and disease context of amidotrizoic acid


Biological context of amidotrizoic acid


Anatomical context of amidotrizoic acid


Associations of amidotrizoic acid with other chemical compounds


Gene context of amidotrizoic acid

  • However there was a more dramatic decrease in phosphorylation of the phosphorylated form of mammalian target of rapamycin (mTOR) and of the extracellular-signal regulated kinases (ERK) 1/2 caused by sodium diatrizoate than by iopromide [31].
  • Monocytes, isolated by Histopaque gradients and centrifugal elutriation, were cultured for 5 days in RPMI-1640 medium with 5% AB serum, and then activated with interferon-gamma (IFN-gamma; 100 U/mL) and lipopolysaccharide (LPS) (5 ng/mL), with or without AEBSF, for 2 days [32].
  • A discontinuous gradient system composed of two commercially available Ficoll-Hypaque mixtures (Mono-Poly resolving medium (MPRM) and Histopaque 1.077) is described for the purification of mononuclear and polymorphonuclear leukocytes from human blood [33].
  • Melanoma cell detection in peripheral blood by tyrosinase reverse transcription-polymerase chain reaction (RT-PCR) is usually performed on RNA isolated from whole blood using a guanidinium isothiocyanate (GITC)/phenol extraction method or from Ficoll Hypaque isolated mononuclear cells [34].
  • CVb and CVr of bolus injection of 51Cr-EDTA, but not CVc of iothalamate and 51Cr-EDTA infusions were twofold to tenfold lower than the percent yearly change reported in IDDM and NIDDM patients [35].

Analytical, diagnostic and therapeutic context of amidotrizoic acid


  1. Single subcutaneous injection of iothalamate sodium I 125 to measure glomerular filtration rate. Adefuin, P.Y., Gur, A., Siegel, N.J., Spencer, R.P., Hayslett, J.P. JAMA (1976) [Pubmed]
  2. Successful treatment of Diphyllobothrium latum and Taenia saginata infection by intraduodenal 'Gastrografin' injection. Waki, K., Oi, H., Takahashi, S., Nakabayashi, T., Kitani, T. Lancet (1986) [Pubmed]
  3. The use of gastrografin for esophageal perforation. Goh, G.J., Pilbrow, W.J., Youngs, G.R. Gastroenterology (1995) [Pubmed]
  4. Treatment of acute colonic pseudoobstruction (Ogilvie's syndrome) with cisapride. MacColl, C., MacCannell, K.L., Baylis, B., Lee, S.S. Gastroenterology (1990) [Pubmed]
  5. Quantitative measurements of capillary transport in human brain tumors by computed tomography. Groothuis, D.R., Vriesendorp, F.J., Kupfer, B., Warnke, P.C., Lapin, G.D., Kuruvilla, A., Vick, N.A., Mikhael, M.A., Patlak, C.S. Ann. Neurol. (1991) [Pubmed]
  6. Membranoproliferative glomerulonephritis. A prospective clinical trial of platelet-inhibitor therapy. Donadio, J.V., Anderson, C.F., Mitchell, J.C., Holley, K.E., Ilstrup, D.M., Fuster, V., Chesebro, J.H. N. Engl. J. Med. (1984) [Pubmed]
  7. Glomerular function in Pima Indians with noninsulin-dependent diabetes mellitus of recent onset. Myers, B.D., Nelson, R.G., Williams, G.W., Bennett, P.H., Hardy, S.A., Berg, R.L., Loon, N., Knowler, W.C., Mitch, W.E. J. Clin. Invest. (1991) [Pubmed]
  8. Barium or gastrografin: which contrast media for diagnosis of esophageal tears? James, A.E., Montali, R.J., Chaffee, V., Strecker, E.P., Vessal, K. Gastroenterology (1975) [Pubmed]
  9. Extrathymic differentiation of T lymphocytes and natural killer cells from human embryonic liver precursors. Poggi, A., Sargiacomo, M., Biassoni, R., Pella, N., Sivori, S., Revello, V., Costa, P., Valtieri, M., Russo, G., Mingari, M.C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  10. Trisomy 7 and trisomy 10 characterize subpopulations of tumor-infiltrating lymphocytes in kidney tumors and in the surrounding kidney tissue. Dal Cin, P., Aly, M.S., Delabie, J., Ceuppens, J.L., Van Gool, S., Van Damme, B., Baert, L., Van Poppel, H., Van den Berghe, H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  11. Acute renal failure in primary macroglobulinemia with small-molecule IgM. Matsumoto, J., Yasaka, T., Ohya, I., Ohtani, H. Arch. Intern. Med. (1985) [Pubmed]
  12. Effect of calcium-binding additives on ventricular fibrillation and repolarization changes during coronary angiography. Zukerman, L.S., Friehling, T.D., Wolf, N.M., Meister, S.G., Nahass, G., Kowey, P.R. J. Am. Coll. Cardiol. (1987) [Pubmed]
  13. 125I-fibrinogen uptake following phlebography of the leg. Comparison of ionic and nonionic contrast media. Walters, H.L., Clemenson, J., Browse, N.L., Thomas, M.L. Radiology. (1980) [Pubmed]
  14. Contrast agent-induced thrombophlebitis following leg phlebography: meglumine loxaglate versus meglumine lothalamate. Thomas, M.L., Briggs, G.M., Kuan, B.B. Radiology. (1983) [Pubmed]
  15. Are iodinated contrast agents detrimental in acute cerebral ischemia? An experimental study in rats. Doerfler, A., Engelhorn, T., von Kummer, R., Weber, J., Knauth, M., Heiland, S., Sartor, K., Forsting, M. Radiology. (1998) [Pubmed]
  16. Increased glomerular filtration rate in patients with major burns and its effect on the pharmacokinetics of tobramycin. Loirat, P., Rohan, J., Baillet, A., Beaufils, F., David, R., Chapman, A. N. Engl. J. Med. (1978) [Pubmed]
  17. Reflex vasodilation induced by coronary angiography in human subjects. Zelis, R., Caudill, C.C., Baggette, K., Mason, D.T. Circulation (1976) [Pubmed]
  18. Subpopulations of common acute lymphoblastic leukemia antigen-positive lymphoid cells in normal bone marrow identified by hematopoietic differentiation antigens. Ryan, D., Kossover, S., Mitchell, S., Frantz, C., Hennessy, L., Cohen, H. Blood (1986) [Pubmed]
  19. Effects of contrast media on renal function in patients with cirrhosis: a prospective study. Guevara, M., Fernández-Esparrach, G., Alessandria, C., Torre, A., Terra, C., Montañà, X., Piera, C., Alvarez, M.L., Jiménez, W., Ginès, P., Arroyo, V. Hepatology (2004) [Pubmed]
  20. Short-term moderate sodium restriction induces relative hyperfiltration in normotensive normoalbuminuric Type I diabetes mellitus. Luik, P.T., Hoogenberg, K., Van Der Kleij, F.G., Beusekamp, B.J., Kerstens, M.N., De Jong, P.E., Dullaart, R.P., Navis, G.J. Diabetologia (2002) [Pubmed]
  21. Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Broxmeyer, H.E., Douglas, G.W., Hangoc, G., Cooper, S., Bard, J., English, D., Arny, M., Thomas, L., Boyse, E.A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  22. Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats. Boigk, G., Stroedter, L., Herbst, H., Waldschmidt, J., Riecken, E.O., Schuppan, D. Hepatology (1997) [Pubmed]
  23. Activation of human peripheral blood monocytes by lipoproteins. Kelley, J.L., Rozek, M.M., Suenram, C.A., Schwartz, C.J. Am. J. Pathol. (1988) [Pubmed]
  24. Phagocytic properties of isolated human eosinophils. Grover, W.H., Winkler, H.H., Normansell, D.E. J. Immunol. (1978) [Pubmed]
  25. Altered renal calcium handling in hypercalcemia of malignancy. Tuttle, K.R., Kunau, R.T., Loveridge, N., Mundy, G.R. J. Am. Soc. Nephrol. (1991) [Pubmed]
  26. Myocardial contrast two-dimensional echocardiography: dose-myocardial effect relations of intracoronary microbubbles. Shapiro, J.R., Xie, F., Meltzer, R.S. J. Am. Coll. Cardiol. (1988) [Pubmed]
  27. Quantification and longitudinal trends of kidney, renal cyst, and renal parenchyma volumes in autosomal dominant polycystic kidney disease. King, B.F., Reed, J.E., Bergstralh, E.J., Sheedy, P.F., Torres, V.E. J. Am. Soc. Nephrol. (2000) [Pubmed]
  28. Changing glomerular filtration with progression from impaired glucose tolerance to Type II diabetes mellitus. Nelson, R.G., Tan, M., Beck, G.J., Bennett, P.H., Knowler, W.C., Mitch, W.E., Blouch, K., Myers, B.D. Diabetologia (1999) [Pubmed]
  29. In vitro effects of radiographic contrast media on the complement system. Hasselbacher, P., Hahn, J. J. Allergy Clin. Immunol. (1980) [Pubmed]
  30. Diagnostic efficacy of excretory urography with low-dose, nonionic contrast media. Gavant, M.L., Ellis, J.V., Klesges, L.M. Radiology. (1992) [Pubmed]
  31. Radiocontrast media cause dephosphorylation of Akt and downstream signaling targets in human renal proximal tubular cells. Andreucci, M., Fuiano, G., Presta, P., Esposito, P., Faga, T., Bisesti, V., Procino, A., Altieri, V., Tozzo, C., Memoli, B., Michael, A. Biochem. Pharmacol. (2006) [Pubmed]
  32. Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor. Nakabo, Y., Pabst, M.J. J. Leukoc. Biol. (1996) [Pubmed]
  33. Superior leukocyte separation with a discontinuous one-step Ficoll-Hypaque gradient for the isolation of human neutrophils. Kalmar, J.R., Arnold, R.R., Warbington, M.L., Gardner, M.K. J. Immunol. Methods (1988) [Pubmed]
  34. Analysis of melanoma cells in peripheral blood by reverse transcription-polymerase chain reaction for tyrosinase and MART-1 after mononuclear cell collection with cell preparation tubes: a comparison with the whole blood guanidinium isothiocyanate RNA isolation method. de Vries, T.J., Fourkour, A., Punt, C.J., Ruiter, D.J., van Muijen, G.N. Melanoma Res. (2000) [Pubmed]
  35. Plasma clearance rate of 51Cr-EDTA provides a precise and convenient technique for measurement of glomerular filtration rate in diabetic humans. Sambataro, M., Thomaseth, K., Pacini, G., Robaudo, C., Carraro, A., Bruseghin, M., Brocco, E., Abaterusso, C., DeFerrari, G., Fioretto, P., Maioli, M., Tonolo, G.C., Crepaldi, G., Nosadini, R. J. Am. Soc. Nephrol. (1996) [Pubmed]
  36. Characterization of right-side-out membrane vesicles rich in (Na,K)-ATPase and isolated from dog kidney outer medulla. Forbush, B. J. Biol. Chem. (1982) [Pubmed]
  37. Esophageal perforations after forceful dilatation in achalasia. Slater, G., Sicular, A.A. Ann. Surg. (1982) [Pubmed]
  38. Brain hemorrhage from intracranial tumor. Little, J.R., Dial, B., Bélanger, G., Carpenter, S. Stroke (1979) [Pubmed]
  39. Changes in the expression of the heme-regulated eIF-2 alpha kinase and heat shock proteins in rabbit reticulocytes maturing during recovery from anemia. Uma, S., Barret, D.J., Matts, R.L. Exp. Cell Res. (1998) [Pubmed]
WikiGenes - Universities