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Gene Review

ry  -  rosy

Drosophila melanogaster

Synonyms: CG7642, Dmel\CG7642, Protein rosy locus, XD, XDH, ...
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Disease relevance of ry

  • Its specific activity is indistinguishable from that of the enzyme purified from fruit flies [Doyle, Burke, Chovnick, Dutton, Whittle and Bray (1996) Eur. J. Biochem. 239, 782-795], and it appears to be more active than recombinant xanthine dehydrogenase produced with the baculovirus system [1].
  • This RNA exhibited tissue-specific distribution that may be pertinent to XD- and XO-mediated oxygen radical injury in ischemia/reperfusion and inflammation [2].
  • The method employs the maroon-like (ma-1) gene and depends on the known hypersensitivity of ma-1 flies lacking xanthine dehydrogenase (XDH) activity to killing by treatments with aqueous purine solutions [3].

High impact information on ry

  • The tissue distribution of XDH activity in all the strains was normal [4].
  • The estimated rate of gene transfer by gene conversion at this region, which is close to an inversion breakpoint, is lower than previous estimates obtained experimentally at the rosy (ry) gene in Drosophila melanogaster [5].
  • The complete nucleotide sequence of human XD was determined; the deduced amino acid sequence encoded a protein of 1336 amino acid residues of M(r) 147,782 [2].
  • We isolated cDNAs encoding xanthine dehydrogenase (XD; xanthine:NAD+ oxidoreductase, EC from a human liver cDNA library [2].
  • Human XD possessed many of the signature sequences typical of XDs from flies and rodents, including an unusual cysteine distribution, a potential 2Fe/2S binding site, and a putative molybdopterin cofactor binding domain [2].

Biological context of ry


Anatomical context of ry


Associations of ry with chemical compounds


Other interactions of ry


Analytical, diagnostic and therapeutic context of ry


  1. Expression of Drosophila melanogaster xanthine dehydrogenase in Aspergillus nidulans and some properties of the recombinant enzyme. Adams, B., Lowe, D.J., Smith, A.T., Scazzocchio, C., Demais, S., Bray, R.C. Biochem. J. (2002) [Pubmed]
  2. cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase. Wright, R.M., Vaitaitis, G.M., Wilson, C.M., Repine, T.B., Terada, L.S., Repine, J.E. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  3. A rapid selection technique for detecting meiotic X-chromosomal nondisjunction in Drosophila melanogaster. Smith, P.D. Mutat. Res. (1983) [Pubmed]
  4. The effect of chromosomal position on the expression of the Drosophila xanthine dehydrogenase gene. Spradling, A.C., Rubin, G.M. Cell (1983) [Pubmed]
  5. Gene conversion is involved in the transfer of genetic information between naturally occurring inversions of Drosophila. Rozas, J., Aguadé, M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  6. The rosy locus in Drosophila melanogaster: xanthine dehydrogenase and eye pigments. Reaume, A.G., Knecht, D.A., Chovnick, A. Genetics (1991) [Pubmed]
  7. Mutations affecting expression of the rosy locus in Drosophila melanogaster. Lee, C.S., Curtis, D., McCarron, M., Love, C., Gray, M., Bender, W., Chovnick, A. Genetics (1987) [Pubmed]
  8. Molecular population genetics of Xdh and the evolution of base composition in Drosophila. Begun, D.J., Whitley, P. Genetics (2002) [Pubmed]
  9. Analysis of xanthine dehydrogenase mRNA levels in mutants affecting the expression of the rosy locus. Covington, M., Fleenor, D., Devlin, R.B. Nucleic Acids Res. (1984) [Pubmed]
  10. Heterochromatic position effect at the rosy locus of Drosophila melanogaster: cytological, genetic and biochemical characterization. Rushlow, C.A., Chovnick, A. Genetics (1984) [Pubmed]
  11. Studies on the mechanism of heterochromatic position effect at the rosy locus of Drosophila melanogaster. Rushlow, C.A., Bender, W., Chovnick, A. Genetics (1984) [Pubmed]
  12. Urate-null rosy mutants of Drosophila melanogaster are hypersensitive to oxygen stress. Hilliker, A.J., Duyf, B., Evans, D., Phillips, J.P. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  13. The hxB gene, necessary for the post-translational activation of purine hydroxylases in Aspergillus nidulans, is independently controlled by the purine utilization and the nicotinate utilization transcriptional activating systems. Amrani, L., Cecchetto, G., Scazzocchio, C., Glatigny, A. Mol. Microbiol. (1999) [Pubmed]
  14. Drosophila melanogaster ma-l mutants are defective in the sulfuration of desulfo Mo hydroxylases. Wahl, R.C., Warner, C.K., Finnerty, V., Rajagopalan, K.V. J. Biol. Chem. (1982) [Pubmed]
  15. Chromosomal walking and jumping to isolate DNA from the Ace and rosy loci and the bithorax complex in Drosophila melanogaster. Bender, W., Spierer, P., Hogness, D.S. J. Mol. Biol. (1983) [Pubmed]
  16. Nearly identical allelic distributions of xanthine dehydrogenase in two populations of Drosophila pseudoobscura. Keith, T.P., Brooks, L.D., Lewontin, R.C., Martinez-Cruzado, J.C., Rigby, D.L. Mol. Biol. Evol. (1985) [Pubmed]
  17. Cloning of two Bombyx homologues of the Drosophila rosy gene and their relationship to larval translucent skin colour mutants. Yasukochi, Y., Kanda, T., Tamura, T. Genet. Res. (1998) [Pubmed]
  18. An analysis of xanthine dehydrogenase negative mutants of the rosy locus in Drosophila melanogaster. Girton, L.E., Lo, R.Y., Bell, J.B. Can. J. Genet. Cytol. (1979) [Pubmed]
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