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Gene Review

IGFBP5  -  insulin-like growth factor binding protein 5

Ovis aries

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Disease relevance of IGFBP-5

  • We conclude that locally produced IGFBPs, in particular IGFBP-5, may play a critical role in the regulation of cartilage matrix degradation in inflammatory and degenerative arthritides [1].

High impact information on IGFBP-5


Biological context of IGFBP-5


Anatomical context of IGFBP-5


Associations of IGFBP-5 with chemical compounds


Analytical, diagnostic and therapeutic context of IGFBP-5

  • Furthermore, IL-1alpha, but not IGF-I, induced IGFBP-5 messenger RNA expression, as assessed by Northern blot analysis [1].
  • In conclusion, we show that IGFBP-5 is specifically cleaved by a serine protease released by primary cultures of ovine articular chondrocytes and also demonstrate the ability of IGF-I to inhibit the proteolytic activity both in cell culture and in cell-free conditions [7].


  1. Regulation of insulin-like growth factor-binding protein-5 by insulin-like growth factor I and interleukin-1alpha in ovine articular chondrocytes. Sunic, D., McNeil, J.D., Rayner, T.E., Andress, D.L., Belford, D.A. Endocrinology (1998) [Pubmed]
  2. Expression and release of insulin-like growth factor binding proteins in isolated epiphyseal growth plate chondrocytes from the ovine fetus. De Los Rios, P., Hill, D.J. J. Cell. Physiol. (2000) [Pubmed]
  3. Expression of insulin-like growth factor binding protein-5 by ovine granulosa cells is regulated by cell density and programmed cell death in vitro. Monget, P., Pisselet, C., Monniaux, D. J. Cell. Physiol. (1998) [Pubmed]
  4. Regulation and localization of insulin-like growth factor binding protein-5 gene expression in the uterus and placenta of the cyclic and early pregnant ewe. Gadd, T.S., Osgerby, J.C., Wathes, D.C. Biol. Reprod. (2000) [Pubmed]
  5. Effect of maternal body condition on placental and fetal growth and the insulin-like growth factor axis in Dorset ewes. Osgerby, J.C., Gadd, T.S., Wathes, D.C. Reproduction (2003) [Pubmed]
  6. Estradiol increases relative amounts of insulin-like growth factor binding protein (IGFBP)-3 in serum and expression of IGFBP-2 in anterior pituitaries of ewes. Clapper, J.A., Snyder, J.L., Roberts, A.J., Hamernik, D.L., Moss, G.E. Biol. Reprod. (1998) [Pubmed]
  7. Insulin-like growth factor binding protein-5 proteolytic activity in ovine articular chondrocyte culture. Sunic, D., McNeil, J.D., Andress, D.L., Belford, D.A. Biochim. Biophys. Acta (1998) [Pubmed]
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