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Gene Review:

IGFBP5 - insulin-like growth factor binding protein 5

Ovis aries

Monget, P. et al., Gadd, T.S. et al., Sunic, D. et al., Sunic, D. et al., De Los Rios, P. et al., et al.

Monget, Pisselet, Monniaux,

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Disease relevance of IGFBP-5

We conclude that locally produced IGFBPs, in particular IGFBP-5, may play a critical role in the regulation of cartilage matrix degradation in inflammatory and degenerative arthritides [1].

High impact information on IGFBP-5

Insulin (16.7 or 167 nM) selectively increased mRNA and the release of IGFBP-3, while cortisol (1 or 5 microM) inhibited both mRNA and release of IGFBP-2 and IGFBP-5 [2].
The release of IGFBP-2 and IGFBP-5 were also potentiated without changes to steady state mRNA, and for IGFBP-5 this was due in part to a release from the cell membrane in the presence of IGF-II [2].
In vivo, in the sheep ovary, the expression of insulin-like growth factor binding protein (IGFBP)-2 and particularly IGFBP-5 has been shown to increase dramatically in apoptotic granulosa cells from atretic follicles [3].
Furthermore, expression of IGFBP-5 mRNA was shown to increase with both cell density and cell death [3].
In vitro, IGFBP-2 and particularly IGFBP-5 were the main IGFBPs secreted by ovine granulosa cells [3].

Biological context of IGFBP-5

In contrast, the amount of IGFBP-5 present in culture medium was positively correlated to cell density [3].
These data suggest that IGFBP-5 is involved in both growth arrest and apoptosis of granulosa cells in the sheep [3].
Overall, these results indicate that, in vitro, the localization of IGFBP-5 on ovine granulosa cell membranes and in culture medium, respectively, was mainly dependent on cell density, whereas expression of IGFBP-5 mRNA was related to both cell density and cell death [3].
In these regions IGFBP-5 mRNA showed cyclic variations, with concentrations peaking around ovulation, whereas low expression in the endometrial stroma remained constant [4].
Regulation and localization of insulin-like growth factor binding protein-5 gene expression in the uterus and placenta of the cyclic and early pregnant ewe [4].

Anatomical context of IGFBP-5

In the intercotyledonary endometrium, IGFBP-3, IGFBP-5 and uterine milk protein (UTMP) mRNA were all expressed in the glandular epithelium [5].
Regulation of insulin-like growth factor-binding protein-5 by insulin-like growth factor I and interleukin-1alpha in ovine articular chondrocytes [1].

Associations of IGFBP-5 with chemical compounds

In nonpregnant ewes, IGFBP-5 mRNA was present at high concentrations in the maternal caruncles and luminal epithelium, and at moderate levels in myometrium [4].
In the SME, IGFBP-2, IGFBP-5, and the 40-kDa IGFBP-3 were increased by estradiol [6].
Serine protease inhibitors aprotinin and heparin effectively inhibited the breakdown of IGFBP-5 [7].

Analytical, diagnostic and therapeutic context of IGFBP-5

Furthermore, IL-1alpha, but not IGF-I, induced IGFBP-5 messenger RNA expression, as assessed by Northern blot analysis [1].
In conclusion, we show that IGFBP-5 is specifically cleaved by a serine protease released by primary cultures of ovine articular chondrocytes and also demonstrate the ability of IGF-I to inhibit the proteolytic activity both in cell culture and in cell-free conditions [7].

References

Regulation of insulin-like growth factor-binding protein-5 by insulin-like growth factor I and interleukin-1alpha in ovine articular chondrocytes. Sunic, D., McNeil, J.D., Rayner, T.E., Andress, D.L., Belford, D.A. Endocrinology (1998) [Pubmed]
Expression and release of insulin-like growth factor binding proteins in isolated epiphyseal growth plate chondrocytes from the ovine fetus. De Los Rios, P., Hill, D.J. J. Cell. Physiol. (2000) [Pubmed]
Expression of insulin-like growth factor binding protein-5 by ovine granulosa cells is regulated by cell density and programmed cell death in vitro. Monget, P., Pisselet, C., Monniaux, D. J. Cell. Physiol. (1998) [Pubmed]
Regulation and localization of insulin-like growth factor binding protein-5 gene expression in the uterus and placenta of the cyclic and early pregnant ewe. Gadd, T.S., Osgerby, J.C., Wathes, D.C. Biol. Reprod. (2000) [Pubmed]
Effect of maternal body condition on placental and fetal growth and the insulin-like growth factor axis in Dorset ewes. Osgerby, J.C., Gadd, T.S., Wathes, D.C. Reproduction (2003) [Pubmed]
Estradiol increases relative amounts of insulin-like growth factor binding protein (IGFBP)-3 in serum and expression of IGFBP-2 in anterior pituitaries of ewes. Clapper, J.A., Snyder, J.L., Roberts, A.J., Hamernik, D.L., Moss, G.E. Biol. Reprod. (1998) [Pubmed]
Insulin-like growth factor binding protein-5 proteolytic activity in ovine articular chondrocyte culture. Sunic, D., McNeil, J.D., Andress, D.L., Belford, D.A. Biochim. Biophys. Acta (1998) [Pubmed]

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