The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

CD4  -  CD4 molecule

Ovis aries

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CD4

  • Crescentic glomerulonephritis in CD4- and CD8-deficient mice. Requirement for CD4 but not CD8 cells [1].
  • They support the hypothesis that crescent formation is a manifestation of CD4-dependent (and CD8-independent) delayed type hypersensitivity in the glomerulus [1].
  • These results demonstrate that vaccination with VV recombinants containing the complete env gene of BLV protects sheep against infection and that protection correlated with a CD4 T-cell response to a defined epitope [2].
  • In this study we have depleted various subpopulations of T cells in vivo and shown that the population of CD4-8-TcR alpha beta+ T cells is responsible for providing "help" in the antibody response of CD4-deficient mice to vesicular stomatitis virus infection [3].

High impact information on CD4

  • The surface phenotypes (CD1, CD4, CD5, CD8, SBU-T19, MHC class I, MHC class II, and sIg) of cells in blood, lymph nodes, and lymph were determined to examine simultaneously the distribution of lymphocyte subsets circulating in blood, afferent lymph, and efferent lymph of a peripheral lymph node [4].
  • Taken together, these results are the first to show that gamma delta-TCR bearing CD3+, CD4-, and CD8- T cells are functional and reverse oral tolerance when adoptively transferred [5].
  • Sheep inoculated with recombinants containing the complete env gene showed a CD4 response to a defined epitope of gp51, but this response was absent 4 months postchallenge [2].
  • Protection of sheep against bovine leukemia virus (BLV) infection by vaccination with recombinant vaccinia viruses expressing BLV envelope glycoproteins: correlation of protection with CD4 T-cell response to gp51 peptide 51-70 [2].
  • Blood and lymph lymphocytes were phenotyped using monoclonal antibodies against CD4, CD8, gd T-cell receptors and a surface marker on ovine B cells [6].

Biological context of CD4


Anatomical context of CD4

  • Previously, we and others have demonstrated that CD4-deficient mice have a normal number of T cells and B cells with a significant population of CD4-8-TcR alpha beta+ T cells [3].
  • These results indicate that CD4 is not absolutely necessary for positive selection or effector function of class II MHC-restricted helper T cells [3].
  • The dietary alpha-linolenate to linoleate balance was reflected in the proportion of (n-3) and (n-6) highly unsaturated fatty acids with 20- and 22-carbon chains in spleen phospholipids, but the ratio did not affect the proportion of T lymphocyte subsets expressing CD4 and CD8 antigens in splenic leukocytes [11].
  • The relative proportions of CD5, CD4, CD8, SBU-T19 and surface immunoglobulin (sIg)-positive lymphocytes in normal sheep livers were determined by flow cytometry analysis of isolated liver leucocytes and compared to lymphocyte subpopulations found in peripheral blood and hepatic lymph nodes [12].
  • Eosinophils in blood and mammary glands were negative for MHC class II, CD25 and CD4 [13].

Associations of CD4 with chemical compounds

  • The study of calcium mobilization and tyrosine kinase activation, mediated by CD4 cross-linking permitted verification of the functionality of cells [14].
  • It was found that aurintricarboxylic acid (ATA) was a particularly effective inhibitor, blocking mAb binding to human, mouse, pig, sheep and rat CD4 by greater than 90% and to chicken CD4 by 80-90% [15].
  • This paper introduces a transgenic (Tg) mouse in which the majority of the CD4-bearing T cells have T-cell receptors that react with ovalbumin (OVA) as a model for ethanol research [16].
  • RESULTS: At baseline, we found significant differences in the expression of CD4, CD8, and L selectin between peripheral blood T cells and tissue T cells [17].
  • Depending on the time of exposure to cyclophosphamide, DTC either increased the percentage of CD4 thymocytes or decreased the percentage of CD8, which subsequently led increased CD4/CD8 coefficient [18].

Other interactions of CD4


Analytical, diagnostic and therapeutic context of CD4


  1. Crescentic glomerulonephritis in CD4- and CD8-deficient mice. Requirement for CD4 but not CD8 cells. Tipping, P.G., Huang, X.R., Qi, M., Van, G.Y., Tang, W.W. Am. J. Pathol. (1998) [Pubmed]
  2. Protection of sheep against bovine leukemia virus (BLV) infection by vaccination with recombinant vaccinia viruses expressing BLV envelope glycoproteins: correlation of protection with CD4 T-cell response to gp51 peptide 51-70. Gatei, M.H., Naif, H.M., Kumar, S., Boyle, D.B., Daniel, R.C., Good, M.F., Lavin, M.F. J. Virol. (1993) [Pubmed]
  3. Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice. Rahemtulla, A., Kündig, T.M., Narendran, A., Bachmann, M.F., Julius, M., Paige, C.J., Ohashi, P.S., Zinkernagel, R.M., Mak, T.W. Eur. J. Immunol. (1994) [Pubmed]
  4. Lymphocyte subsets show marked differences in their distribution between blood and the afferent and efferent lymph of peripheral lymph nodes. Mackay, C.R., Kimpton, W.G., Brandon, M.R., Cahill, R.N. J. Exp. Med. (1988) [Pubmed]
  5. Immunoregulatory function of CD3+, CD4-, and CD8- T cells. Gamma delta T cell receptor-positive T cells from nude mice abrogate oral tolerance. Fujihashi, K., Kiyono, H., Aicher, W.K., Green, D.R., Singh, B., Eldridge, J.H., McGhee, J.R. J. Immunol. (1989) [Pubmed]
  6. The relationship of lymphocytes in blood and in lymph to sleep/wake states in sheep. Dickstein, J.B., Hay, J.B., Lue, F.A., Moldofsky, H. Sleep. (2000) [Pubmed]
  7. Evidence for delayed-type hypersensitivity mechanisms in glomerular crescent formation. Huang, X.R., Holdsworth, S.R., Tipping, P.G. Kidney Int. (1994) [Pubmed]
  8. Cellular phenotypes in Trypanosoma congolense infected sheep: the local skin reaction. Mwangi, D.M., Hopkins, J., Luckins, A.G. Parasite Immunol. (1990) [Pubmed]
  9. Conditioned inhibition of antibody response and CD4 positive cells. Napolitano, F., De Rosa, G., Grasso, F., Migliori, G., Bordi, A. Physiol. Behav. (1998) [Pubmed]
  10. Influences of long-term antibiotic administration on Peyer's patch lymphocytes and mucosal immunoglobulin A levels in a mouse model. Yaguchi, Y., Fukatsu, K., Moriya, T., Maeshima, Y., Ikezawa, F., Omata, J., Ueno, C., Okamoto, K., Hara, E., Ichikura, T., Hiraide, H., Mochizuki, H., Touger-Decker, R.E. JPEN. Journal of parenteral and enteral nutrition. (2006) [Pubmed]
  11. A high alpha-linolenate diet suppresses antigen-induced immunoglobulin E response and anaphylactic shock in mice. Watanabe, S., Sakai, N., Yasui, Y., Kimura, Y., Kobayashi, T., Mizutani, T., Okuyama, H. J. Nutr. (1994) [Pubmed]
  12. Presence of a distinct CD8+ and CD5- leucocyte subpopulation in the sheep liver. Meeusen, E., Gorrell, M.D., Brandon, M.R. Immunology (1988) [Pubmed]
  13. An in vivo mammary infusion model for tissue migration of leucocytes during inflammation. Greenhalgh, C.J., Jacobs, H.J., Meeusen, E.N. Immunol. Cell Biol. (1996) [Pubmed]
  14. Purification of functional T lymphocytes from splenocytes of the beluga whales (Delphinapterus leucas). Bernier, J., De Guise, S., Martineau, D., Béland, P., Beaudet, M., Fournier, M. Dev. Comp. Immunol. (2000) [Pubmed]
  15. Conservation of a polyanion binding site in mammalian and avian CD4. Parish, C.R., Warren, H.S. Immunology (1991) [Pubmed]
  16. Ethanol ingestion inhibits cell-mediated immune responses of unprimed T-cell receptor transgenic mice. Schodde, H., Hurst, S., Munroe, M., Barrett, T., Waltenbaugh, C. Alcohol. Clin. Exp. Res. (1996) [Pubmed]
  17. Posttraumatic lymphocyte response: a comparison between peripheral blood T cells and tissue T cells. Aguilar, M.M., Battistella, F.D., Owings, J.T., Olson, S.A., MacColl, K. The Journal of trauma. (1998) [Pubmed]
  18. The effect of DTC on humoral response restoration and thymocyte subpopulations in cyclophosphamide-immunosuppressed mice. Obmińska-Domoradzka, B. Immunopharmacology and immunotoxicology. (1994) [Pubmed]
  19. Antigen recognition and activation of ovine gamma delta T cells. Evans, C.W., Lund, B.T., McConnell, I., Bujdoso, R. Immunology (1994) [Pubmed]
  20. Type II collagen-immune complex arthritis in sheep: collagen antibodies in serum, synovial fluid and afferent lymph. Thorp, B.H., Kimpton, W.G., Washington, E.A., Morrow, C.J., Rowley, M.J. Clinical and experimental rheumatology. (1992) [Pubmed]
WikiGenes - Universities