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Crim1  -  cysteine rich transmembrane BMP regulator...

Mus musculus

Synonyms: AU015004, CRIM-1, Cysteine-rich motor neuron 1 protein
 
 
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Disease relevance of Crim1

  • Crim1 is also detected in other developing ocular tissues including corneal and conjunctival epithelia, corneal endothelium, retinal pigmented epithelium, ciliary and iridial retinae and ganglion cells [1].
  • Surprisingly, anti-idiotypic antibodies (anti-SJ-CRIM), which describe the mouse correlate CRIM were not suppressive in the human blastogenesis or in vitro granuloma formation assays [2].
 

High impact information on Crim1

  • The severe and complex phenotype observed in Crim1(KST264/KST264) mice highlights the importance of Crim1 in numerous aspects of organogenesis [3].
  • A mouse line, KST264, generated in a LacZ insertion mutagenesis gene-trap screen, was examined to elucidate Crim1 function in development [3].
  • Transgene expression recapitulated known Crim1 expression in lens, brain, and limb, but also revealed expression in the smooth muscle cells of the developing heart and renal vasculature, developing cartilage, mature ovary and detrusor of the bladder [3].
  • In ovo electroporation of Crim1 in the developing chick spinal cord [4].
  • Crim1 is expressed in the neural tube in mouse in a restricted pattern, but its function in central nervous system development is largely unknown [4].
 

Biological context of Crim1

  • Thus, strong expression of Crim1 is a distinctive feature of the lens during morphogenesis and postnatal growth [1].
 

Anatomical context of Crim1

  • As lens fibres mature in the nucleus, Crim1 is downregulated but strong expression is maintained in the lens epithelium and in the young fibre cells of the lens cortex [1].
  • Crim1 is expressed in a similar but not identical pattern to that in the developing spinal cord of mouse, including the notochord, floor plate, motor neurons, and the roof plate [4].
 

Associations of Crim1 with chemical compounds

  • Administration of the methionine analogue methoxinine (O-methyl-DL-homoserine) to sheep substantially changed the composition of wool; in addition wool fibres were weakened and the staple crimp frequency was reduced for a prolonged period [5].
  • The methionine analogue, methoxinine (O-methyl-DL-homoserine), caused a substantial reduction in the strength of wool fibres and a prolonged alteration of the crimp pattern [6].
  • These experiments supported a previous finding that the cystine content of wool and its crimp frequency are not causally related [5].
  • Crim1 and VEGF-A were shown to interact directly, providing evidence that cysteine-rich repeat-containing proteins can bind to non-TGF-beta superfamily ligands [7].
 

Other interactions of Crim1

  • Despite the wealth of morphological information about the extracellular matrix in this joint, little is known regarding the involvement of the crimp of collagen fibers in the dramatic transformations occurring in this region during the last 3 days of pregnancy [8].

References

  1. Expression of Crim1 during murine ocular development. Lovicu, F.J., Kolle, G., Yamada, T., Little, M.H., McAvoy, J.W. Mech. Dev. (2000) [Pubmed]
  2. Function and expression of a human idiotypic network in Schistosomiasis japonica. Wisnewski, A.V., Olds, G.R., Johnson, J.H., Ramirez, B., Kresina, T.F. Parasite Immunol. (1996) [Pubmed]
  3. Crim1(KST264/KST264) mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems. Pennisi, D.J., Wilkinson, L., Kolle, G., Sohaskey, M.L., Gillinder, K., Piper, M.J., McAvoy, J.W., Lovicu, F.J., Little, M.H. Dev. Dyn. (2007) [Pubmed]
  4. In ovo electroporation of Crim1 in the developing chick spinal cord. Kolle, G., Jansen, A., Yamada, T., Little, M. Dev. Dyn. (2003) [Pubmed]
  5. Effects of phenylalanine and analogues of methionine and phenylalanine on the composition of wool and mouse hair. Reis, P.J., Gillespie, J.M. Aust. J. Biol. Sci. (1985) [Pubmed]
  6. Investigation of some amino acid analogues and metabolites as inhibitors of wool and hair growth. Reis, P.J., Tunks, D.A., Rigby, R.D., Morton, T.C., Munro, S.G. Aust. J. Biol. Sci. (1983) [Pubmed]
  7. Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development. Wilkinson, L., Gilbert, T., Kinna, G., Ruta, L.A., Pennisi, D., Kett, M., Little, M.H. J. Am. Soc. Nephrol. (2007) [Pubmed]
  8. Histochemical and ultrastructural study of collagen fibers in mouse pubic symphysis during late pregnancy. Pinheiro, M.C., Moraes, S.G., Battlehner, C.N., Caldini, E.G., Toledo, O.M., Joazeiro, P.P. Micron (2004) [Pubmed]
 
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