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Gene Review

CRIM1  -  cysteine rich transmembrane BMP regulator...

Homo sapiens

Synonyms: CRIM-1, Cysteine-rich motor neuron 1 protein, Cysteine-rich repeat-containing protein S52, S52, UNQ1886/PRO4330
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Disease relevance of CRIM1

  • Because the E233X mutation expressed no activity and the K157Q allele had approximately 1% normal specific activity based on cross-reacting immunologic material (CRIM SA) in the baculovirus system, the residual activity in both patients was primarily from their complex alleles [1].
  • Giardiasis. A crimp in the life-style of campers, travelers, and others [2].
  • St 14 (DX S52) VNTR polymorphism in the Indian population and its application in carrier detection and prenatal diagnosis of haemophilia A families [3].
  • Three residues which have been shown to be important for catalysis in bacterial toxins (e.g. R9, S52 and E129 in pertussis toxin) occur in a similar context also in RT6 (R126, S147 and E189) [4].

High impact information on CRIM1

  • CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo [5].
  • Here, we report the further characterization of one selected gene called cysteine-rich motor neuron 1 (CRIM1) [5].
  • Crimp angle did not display any region-specific differences, or any difference between the rupture and intact tendons [6].
  • The present study examined the hypothesis that collagen fibril diameter and crimp angle in ruptured human Achilles tendons differed from that of intact ones [6].
  • Human CRIM1 maps to chromosome 2p21 close to the Spastic Paraplegia 4 locus [7].

Biological context of CRIM1

  • CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis [7].
  • There is evidence that myofibroblasts may be involved in maintaining tissue homeostasis in the mature ligament e.g., by means of crimp formation [8].
  • In conclusion, the results suggest that the use of the "crimp" or the "slope" grip does not provide any benefit with respect to muscular fatigue in sport climbing [9].
  • An Arg to Trp substitution at codon 173 (CGG-->TGG in exon 10) and designated R173W, which leads to a CRIM-negative phenotype, has been reported in Swedish, Finnish, Scottish, and South African kindreds, and in a Nova Scotian proband with fatal AIP [10].
  • Quantitative trait loci (QTL) mapping for bean traits and the number of ovules per ovary was carried out in cocoa (Theobroma cacao L.) using three test-cross progenies derived from crosses between a lower Amazon Forastero male parent (Catongo) and three female parents: one upper Amazon Forastero (IMC78) and two Trinitario (DR1 and S52) [11].

Anatomical context of CRIM1


Associations of CRIM1 with chemical compounds

  • As the nephron elongates, Crim1 becomes expressed in the proximal end of the S-shaped bodies [12].
  • Controlled exercise and anabolic steroid administration produced the greatest change in crimp parameters and the largest theoretical toe limit strain [14].
  • BACKGROUND: The Mosaic bioprosthesis is a porcine valve combining several new features to improve hemodynamics and durability: a low profile stent for reduced flow obstruction, zero pressure fixation to maintain the natural collagen crimp, and the amino oleic acid antimineralization treatment to enhance durability [15].
  • Many of the titanium cables failed immediately under higher loads (0-100 lb) because of slipping of the crimp [16].
  • The largest amount of bowstringing was caused by the flexor digitorum profundus tendon in the crimp grip position being less using slope grip position (PIP joint extended) [17].

Analytical, diagnostic and therapeutic context of CRIM1

  • The cross-sectional area density and diameter distribution of fibrils were analyzed using stereological techniques of digitized electron microscopy biopsy cross-sections, while crimp angle was measured by the changing banding pattern of collagen fibers when rotated between crossed polars [6].
  • The snare was tightly closed to crimp the stent onto the collapsed balloon; this maneuver was repeated several times until the stent was contracted along its entire length [18].
  • After treatment, we measured tendon cellularity, crimp structure, and mechanical properties [19].
  • Polarized light microscopy showed a characteristic crimp pattern in excised tendons, but this was hardly detectable in unloaded tendons and not detectable in tendons fixed in situ under a 1-kg load [20].
  • We measured the velocity profiles for each prosthesis corresponding to four crimp densities obtained by stretching the grafts [21].


  1. Non-pseudogene-derived complex acid beta-glucosidase mutations causing mild type 1 and severe type 2 gaucher disease. Grace, M.E., Ashton-Prolla, P., Pastores, G.M., Soni, A., Desnick, R.J. J. Clin. Invest. (1999) [Pubmed]
  2. Giardiasis. A crimp in the life-style of campers, travelers, and others. Holtan, N.R. Postgraduate medicine. (1988) [Pubmed]
  3. St 14 (DX S52) VNTR polymorphism in the Indian population and its application in carrier detection and prenatal diagnosis of haemophilia A families. Shetty, S., Ghosh, K., Mohanty, D. Haematologia (Budap) (2000) [Pubmed]
  4. Using secondary structure predictions and site-directed mutagenesis to identify and probe the role of potential active site motifs in the RT6 mono(ADP-ribosyl)transferases. Bredehorst, K., Wursthorn, K., Thiele, H.G., Haag, F., Koch-Nolte, F. Adv. Exp. Med. Biol. (1997) [Pubmed]
  5. CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo. Glienke, J., Sturz, A., Menrad, A., Thierauch, K.H. Mech. Dev. (2002) [Pubmed]
  6. Collagen fibril size and crimp morphology in ruptured and intact Achilles tendons. Magnusson, S.P., Qvortrup, K., Larsen, J.O., Rosager, S., Hanson, P., Aagaard, P., Krogsgaard, M., Kjaer, M. Matrix Biol. (2002) [Pubmed]
  7. CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. Kolle, G., Georgas, K., Holmes, G.P., Little, M.H., Yamada, T. Mech. Dev. (2000) [Pubmed]
  8. Alpha-smooth muscle actin is expressed by fibroblastic cells of the ovine anterior cruciate ligament and its free tendon graft during remodeling. Weiler, A., Unterhauser, F.N., Bail, H.J., Hüning, M., Haas, N.P. J. Orthop. Res. (2002) [Pubmed]
  9. Maximal resultant four fingertip force and fatigue of the extrinsic muscles of the hand in different sport climbing finger grips. Quaine, F., Vigouroux, L. International journal of sports medicine. (2004) [Pubmed]
  10. Detection of a R173W mutation in the porphobilinogen deaminase gene in the Nova Scotian "foreign Protestant" population with acute intermittent porphyria: a founder effect. Greene-Davis, S.T., Neumann, P.E., Mann, O.E., Moss, M.A., Schreiber, W.E., Welch, J.P., Langley, G.R., Sangalang, V.E., Dempsey, G.I., Nassar, B.A. Clin. Biochem. (1997) [Pubmed]
  11. Mapping quantitative trait loci for bean traits and ovule number in Theobroma cacao L. Clement, D., Risterucci, A.M., Motamayor, J.C., N'Goran, J., Lanaud, C. Genome (2003) [Pubmed]
  12. Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern. Georgas, K., Bowles, J., Yamada, T., Koopman, P., Little, M.H. Dev. Dyn. (2000) [Pubmed]
  13. Fibroblast distribution in the anteromedial bundle of the human anterior cruciate ligament: the presence of alpha-smooth muscle actin-positive cells. Murray, M.M., Spector, M. J. Orthop. Res. (1999) [Pubmed]
  14. The effect of exercise and anabolic steroids on the mechanical properties and crimp morphology of the rat tendon. Wood, T.O., Cooke, P.H., Goodship, A.E. The American journal of sports medicine. (1988) [Pubmed]
  15. The mosaic bioprosthesis in the aortic position: hemodynamic performance after 2 years. Eichinger, W.B., Schütz, A., Simmerl, D., Gansera, B.U., Breuer, M., Haslinger, B., Kemkes, B.M. Ann. Thorac. Surg. (1998) [Pubmed]
  16. The use of sublaminar cables to replace Luque wires. Songer, M.N., Spencer, D.L., Meyer, P.R., Jayaraman, G. Spine. (1991) [Pubmed]
  17. Biomechanical properties of the crimp grip position in rock climbers. Schweizer, A. Journal of biomechanics. (2001) [Pubmed]
  18. Crimping and repositioning of a maldeployed balloon-expandable arterial stent using a gooseneck snare. Portugaller, H.R., Pabst, E., Doerfler, O.C., Tauss, J., Zangrando, M., Pilger, E., Klein, G.E. J. Endovasc. Ther. (2005) [Pubmed]
  19. Development of cell-seeded patellar tendon allografts for anterior cruciate ligament reconstruction. Cartmell, J.S., Dunn, M.G. Tissue engineering. (2004) [Pubmed]
  20. In situ monitoring of tendon structural changes by elastic scattering spectroscopy: correlation with changes in collagen fibril diameter and crimp. Morgan, M., Kostyuk, O., Brown, R.A., Mudera, V. Tissue Eng. (2006) [Pubmed]
  21. Influence of crimping textile polyester vascular prostheses on the fluid flow kinetics. Groupe Européen de Recherche sur les Prothèses appliquées à la Chirurgie Vasculaire. Abdessalem, S.B., Chakfe, N., Le Magnen, J.F., Beaufigeau, M., Adolphe, D., Geny, B., Akesbi, S., Riepe, G., Kretz, J.G., Durand, B. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. (1999) [Pubmed]
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