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Gene Review

PTOV1  -  prostate tumor overexpressed 1

Homo sapiens

Synonyms: ACID2, Activator interaction domain-containing protein 2, PP642, PTOV-1, Prostate tumor-overexpressed gene 1 protein, ...
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Disease relevance of PTOV1

  • PTOV1 was recently identified as a novel gene and protein during a differential display screening for genes overexpressed in prostate cancer [1].
  • By immunohistochemical analysis, we have found that PTOV1 is overexpressed in 71% of 38 prostate carcinomas and in 80% of samples with prostate intraepithelial neoplasia [1].
  • Semiquantitative RT-PCR has established that nine out of 11 tumors overexpress PTOV1 at levels significantly higher than benign prostatic hyperplasia or normal prostate tissue [2].
  • In normal prostate tissue and in prostate adenomas, PTOV1 was undetectable or expressed at low levels, whereas nine out of 11 prostate adenocarcinomas showed a strong immunoreactivity, with a focal distribution in areas of carcinoma and prostatic intraepithelial neoplasia [2].
  • These findings indicate that the PTOV1 gene is androgen-responsive in VSMCs and that it may play an important role in androgen-related atherogenesis in the human aorta, particularly early atherosclerosis in the male aorta, through regulating proliferation of neointimal VSMCs [3].

High impact information on PTOV1


Biological context of PTOV1


Anatomical context of PTOV1

  • Immunocytochemical analysis and expression of chimeric GFP-PTOV1 proteins in cultured cells showed a predominantly perinuclear localization of PTOV1 [2].
  • A 1.8-Kb PTOV1 transcript was detected abundantly in normal human brain, heart, skeletal muscle, kidney and liver, and at low levels in normal prostate [2].
  • Both microarray and quantitative RT-PCR analyses demonstrated marked induction of the human prostate overexpressed protein 1 (PTOV1) gene by testosterone in the cell lines: this gene was recently identified as a novel androgen-induced gene involved in prostate tumour cell proliferation [3].

Associations of PTOV1 with chemical compounds


Physical interactions of PTOV1

  • We show here that PTOV1 interacts with the lipid raft protein flotillin-1, with which it copurifies in detergent-insoluble floating fractions [5].

Other interactions of PTOV1

  • PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts [5].


  1. PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle. Santamaría, A., Fernández, P.L., Farré, X., Benedit, P., Reventós, J., Morote, J., Paciucci, R., Thomson, T.M. Am. J. Pathol. (2003) [Pubmed]
  2. PTOV1, a novel protein overexpressed in prostate cancer containing a new class of protein homology blocks. Benedit, P., Paciucci, R., Thomson, T.M., Valeri, M., Nadal, M., Càceres, C., de Torres, I., Estivill, X., Lozano, J.J., Morote, J., Reventós, J. Oncogene (2001) [Pubmed]
  3. PTOV1: a novel testosterone-induced atherogenic gene in human aorta. Nakamura, Y., Suzuki, T., Igarashi, K., Kanno, J., Furukawa, T., Tazawa, C., Fujishima, F., Miura, I., Ando, T., Moriyama, N., Moriya, T., Saito, H., Yamada, S., Sasano, H. J. Pathol. (2006) [Pubmed]
  4. A novel docking site on Mediator is critical for activation by VP16 in mammalian cells. Mittler, G., Stühler, T., Santolin, L., Uhlmann, T., Kremmer, E., Lottspeich, F., Berti, L., Meisterernst, M. EMBO J. (2003) [Pubmed]
  5. PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts. Santamaría, A., Castellanos, E., Gómez, V., Benedit, P., Renau-Piqueras, J., Morote, J., Reventós, J., Thomson, T.M., Paciucci, R. Mol. Cell. Biol. (2005) [Pubmed]
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