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Gene Review

AIG1  -  androgen-induced 1

Homo sapiens

Synonyms: AIG-1, Androgen-induced gene 1 protein, CGI-103, FLJ10485, dJ95L4.1
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Disease relevance of AIG1


Psychiatry related information on AIG1

  • We conclude that androgen-induced changes in Na+ current inactivation are not mediated by PKA and suggest that PKA-mediated increases in Na+ current underlie increases in the amplitude of the electric organ discharge observed in social interactions or with changes in water conductance [6].

High impact information on AIG1


Chemical compound and disease context of AIG1


Biological context of AIG1

  • The IMAP/IAN family of AIG1-like GTPases is conserved among vertebrates and angiosperm plants and has been postulated to regulate apoptosis, particularly in context with diseases such as cancer, diabetes, and infections [17].
  • Vector-driven expression of antisense-AS3 blocked the induction of androgen-induced endogenous AS3 mRNA and blocked the inhibitory effect of androgens on cell proliferation [18].
  • Potential mediators of this androgen-induced proliferative shutoff were identified by means of subtracted cDNA libraries [18].
  • Conversely, downregulation of endogenous Daxx expression by RNA interference enhances androgen-induced prostate-specific antigen expression in LNCaP cells [19].
  • Moreover, androgen-induced IGF-IR up-regulation involves the activation of the Src-extracellular signal-regulated kinase pathway, because it was inhibited by both the Src inhibitor PP2 and the MEK-1 inhibitor PD98059 [20].

Anatomical context of AIG1


Associations of AIG1 with chemical compounds


Physical interactions of AIG1

  • Some AR LBD mutations do not affect ligand binding but they disrupt androgen-induced interaction of the N-terminal motif FXXLF and C-terminal activation function 2 (AF2) [30].

Regulatory relationships of AIG1


Other interactions of AIG1


Analytical, diagnostic and therapeutic context of AIG1


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  10. Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Lin, H.K., Yeh, S., Kang, H.Y., Chang, C. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
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  13. Characterization of selective glucocorticoid-dependent responses in a glucocorticoid-resistant smooth muscle tumor cell line. Fan, W., Cooper, T.M., Norris, J.S. J. Cell. Physiol. (1993) [Pubmed]
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  16. Androgen-induced oxidative stress in human LNCaP prostate cancer cells is associated with multiple mitochondrial modifications. Ripple, M.O., Hagopian, K., Oberley, T.D., Schatten, H., Weindruch, R. Antioxid. Redox Signal. (1999) [Pubmed]
  17. Malaria-suppressible expression of the anti-apoptotic triple GTPase mGIMAP8. Krücken, J., Epe, M., Benten, W.P., Falkenroth, N., Wunderlich, F. J. Cell. Biochem. (2005) [Pubmed]
  18. Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator. Geck, P., Maffini, M.V., Szelei, J., Sonnenschein, C., Soto, A.M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  19. Negative modulation of androgen receptor transcriptional activity by Daxx. Lin, D.Y., Fang, H.I., Ma, A.H., Huang, Y.S., Pu, Y.S., Jenster, G., Kung, H.J., Shih, H.M. Mol. Cell. Biol. (2004) [Pubmed]
  20. Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells. Pandini, G., Mineo, R., Frasca, F., Roberts, C.T., Marcelli, M., Vigneri, R., Belfiore, A. Cancer Res. (2005) [Pubmed]
  21. Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells. Seo, J., Kim, J., Kim, M. Mol. Cells (2001) [Pubmed]
  22. Androgen-induced expression of endoplasmic reticulum (ER) stress response genes in prostate cancer cells. Segawa, T., Nau, M.E., Xu, L.L., Chilukuri, R.N., Makarem, M., Zhang, W., Petrovics, G., Sesterhenn, I.A., McLeod, D.G., Moul, J.W., Vahey, M., Srivastava, S. Oncogene (2002) [Pubmed]
  23. Selective modulation of genomic and nongenomic androgen responses by androgen receptor ligands. Lutz, L.B., Jamnongjit, M., Yang, W.H., Jahani, D., Gill, A., Hammes, S.R. Mol. Endocrinol. (2003) [Pubmed]
  24. Functional analysis of a novel androgen receptor mutation, Q902K, in an individual with partial androgen insensitivity. Umar, A., Berrevoets, C.A., Van, N.M., van Leeuwen, M., Verbiest, M., Kleijer, W.J., Dooijes, D., Grootegoed, J.A., Drop, S.L., Brinkmann, A.O. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
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  29. Androgen-induced NH2- and COOH-terminal Interaction Inhibits p160 coactivator recruitment by activation function 2. He, B., Bowen, N.T., Minges, J.T., Wilson, E.M. J. Biol. Chem. (2001) [Pubmed]
  30. Human androgen receptor gene ligand-binding-domain mutations leading to disrupted interaction between the N- and C-terminal domains. Jääskeläinen, J., Deeb, A., Schwabe, J.W., Mongan, N.P., Martin, H., Hughes, I.A. J. Mol. Endocrinol. (2006) [Pubmed]
  31. Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP-1/c-Jun in the human prostate cancer cell line LNCaP. Sato, N., Sadar, M.D., Bruchovsky, N., Saatcioglu, F., Rennie, P.S., Sato, S., Lange, P.H., Gleave, M.E. J. Biol. Chem. (1997) [Pubmed]
  32. Androgens negatively regulate forkhead transcription factor FKHR (FOXO1) through a proteolytic mechanism in prostate cancer cells. Huang, H., Muddiman, D.C., Tindall, D.J. J. Biol. Chem. (2004) [Pubmed]
  33. p53 represses androgen-induced transactivation of prostate-specific antigen by disrupting hAR amino- to carboxyl-terminal interaction. Shenk, J.L., Fisher, C.J., Chen, S.Y., Zhou, X.F., Tillman, K., Shemshedini, L. J. Biol. Chem. (2001) [Pubmed]
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  36. Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src. Sun, M., Yang, L., Feldman, R.I., Sun, X.M., Bhalla, K.N., Jove, R., Nicosia, S.V., Cheng, J.Q. J. Biol. Chem. (2003) [Pubmed]
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