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Gene Review

SAGE1  -  sarcoma antigen 1

Homo sapiens

Synonyms: CT14, Cancer/testis antigen 14, SAGE, Sarcoma antigen 1
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Disease relevance of SAGE1

  • The Lynn Sage Memorial Lecture: new developments in breast cancer management [1].
  • A reliable quantitative microcytotoxicity technique is presented which demonstrates that: (1) osteosarcoma is not due to host immuno-incompetence, (2) a common sarcoma antigen does not exist and (3) serum blocking factors may occasionally be present [2].
  • Toxicological studies carried out on aqueous extract of Salvia splendens commonly known as Red Sage reveals that the drug is toxic only in higher doses and causes hemorrhages [3].

High impact information on SAGE1

  • Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4{alpha}SG1 and PH4{alpha}SG2 [4].
  • Recently we have identified angiostatin, an endogenous angiogenesis inhibitor of 38 kDa which specifically blocks the growth of endothelial cells (O'Reilly, M. S., Holmgren, L., Shing, Y., Chen, C. , Rosenthal, R. A., Moses, M., Lane, W. S., Cao, Y., Sage, E. H., and Folkman, J. (1994) Cell 79, 315-328; Folkman, J. (1995) Nat. Med. 1, 27-31) [5].
  • The selective ability of angiogenic endothelium to utilize the alpha 1(I)-collagen promoter is consistent with previous studies showing high levels of alpha 1(I)-collagen mRNA in BAE cells actively engaged in the formation of tubes (Iruela-Arispe, L., Hasselaar, P., and Sage, H. (1991) Lab. Invest. 64, 174-186) [6].
  • The N-terminal amino acid sequence of human bone osteonectin was nearly identical to bovine bone osteonectin and had many similarities to a protein found in mouse parietal endoderm (Mason, I.J., Taylor, A., Williams, J.G., Sage, H., and Hogan, B.L.M. (1986) EMBO J [7].
  • A murine monoclonal antibody (MAb 19-24) directed against a human sarcoma antigen was labeled with indium-111 (111In) by use of the linker 1-(p-isothiocyanatobenzyl)-diethylenetriaminepentaacetic acid (SCN-Bz-DTPA) [8].

Biological context of SAGE1


Anatomical context of SAGE1


Associations of SAGE1 with chemical compounds

  • A high molecular weight glycoprotein, reported to be secreted by endothelial cells (Sage, H., Crouch, E., and Bornstein, P. (1979) Biochemistry 18, 5433-5442), has been purified to apparent homogeneity from culture medium of adult bovine aortic endothelial cells [14].
  • A murine monoclonal antibody (MoAb 19-24) directed against a human sarcoma antigen was prepared and labeled with 111In by use of the linker 1-(p-isothiocyanatobenzyl)-diethylenetriaminepentaacetic acid (SCN-Bz-DTPA) [15].
  • The Mail and Mail Plus Incentive interventions were estimated to produce increases in Sage screening rates of 0.23% and 0.75%, respectively, beyond the composite Control rate of 0.83% [16].
  • The objective of the study was to characterize salivary sex steroid levels in 56 women undergoing annual mammography who were participating in a breast density study at the Lynn Sage Breast Center of Northwestern Memorial Hospital, and to determine the predictability of the patterns within women [17].
  • Carnosic Acid and Carnosol, Phenolic Diterpene Compounds of the Labiate Herbs Rosemary and Sage, are Activators of the Human Peroxisome Proliferator-Activated Receptor Gamma [18].

Other interactions of SAGE1

  • This diversity of origins of the water and the existence of a gridded network leads the company in charge of the production and the quality of the water in Paris, Sagep, to partly mix the water in the network [19].

Analytical, diagnostic and therapeutic context of SAGE1

  • Direct mail is an effective strategy for increasing mammography use through Sage. Coupling direct mail with an incentive significantly enhances the intervention's effectiveness [16].
  • METHODS: The strategy and procedures recommended by Hunter and Schmidt [Hunter JE, Schmidt FL. Methods of meta-analysis: correcting error and bias in research findings. Thousand Oaks (CA): Sage, 2004] were followed [20].
  • For a small defect with a favourable prognosis (Boyd and Sage 1958), we recommend conventional bone grafting, intramedullary nailing and electrical stimulation [21].
  • Both inductive and deductive analyses were used to analyse the data [Patton M. Qualitative evaluation and research methods. 2nd ed. Newbury Park: Sage Publications; 1990] [22].
  • Members of our burn team found the Sage II program easy to use and found many of the features useful for patient care [23].


  1. The Lynn Sage Memorial Lecture: new developments in breast cancer management. Veronesi, U. J. Am. Coll. Surg. (2001) [Pubmed]
  2. The host immune response in human osteosarcoma. McMaster, J.H., Ferguson, R.J., Weinert, C.R. Clin. Orthop. Relat. Res. (1975) [Pubmed]
  3. Toxicity and anticoagulant activity of Salvia splendens. Qureshi, I.H., Ahmad, S., Kapadia, Z. Pakistan journal of pharmaceutical sciences. (1989) [Pubmed]
  4. Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4{alpha}SG1 and PH4{alpha}SG2. Abrams, E.W., Mihoulides, W.K., Andrew, D.J. Development (2006) [Pubmed]
  5. Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells. Cao, Y., Ji, R.W., Davidson, D., Schaller, J., Marti, D., Söhndel, S., McCance, S.G., O'Reilly, M.S., Llinás, M., Folkman, J. J. Biol. Chem. (1996) [Pubmed]
  6. Transcriptional activity of the alpha 1(I)-collagen promoter is correlated with the formation of capillary-like structures by endothelial cells in vitro. Fouser, L., Iruela-Arispe, L., Bornstein, P., Sage, E.H. J. Biol. Chem. (1991) [Pubmed]
  7. Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone. Fisher, L.W., Hawkins, G.R., Tuross, N., Termine, J.D. J. Biol. Chem. (1987) [Pubmed]
  8. Localization of pulmonary human sarcoma xenografts in athymic nude mice with indium-111-labeled monoclonal antibodies. Greager, J.A., Chao, T.C., Blend, M.J., Atcher, R.W., Gansow, O.A., Brechbiel, M.W., Das Gupta, T.K. J. Nucl. Med. (1990) [Pubmed]
  9. Use of nonprohibited hallucinogenic plants: increasing relevance for public health? A case report and literature review on the consumption of Salvia divinorum (Diviner's Sage). Bücheler, R., Gleiter, C.H., Schwoerer, P., Gaertner, I. Pharmacopsychiatry (2005) [Pubmed]
  10. Type VIII collagen in the normal and diseased human brain. Paulus, W., Sage, E.H., Jellinger, K., Roggendorf, W. Acta Histochem. Suppl. (1992) [Pubmed]
  11. Social work and the behavioral sciences: past history, future prospects. Bloom, S.W. Social work in health care. (2000) [Pubmed]
  12. Type 5 phosphodiesterase regulation of human sperm motility. Cuadra, D.L., Chan, P.J., Patton, W.C., Stewart, S.C., King, A. Am. J. Obstet. Gynecol. (2000) [Pubmed]
  13. Gynandroblastoma of the ovary: a case report with an immunohistochemical and ultrastructural study. Fukunaga, M., Endo, Y., Ushigome, S. Virchows Arch. (1997) [Pubmed]
  14. Isolation and characterization of a glycoprotein secreted by aortic endothelial cells in culture. Apparent identity with platelet thrombospondin. McPherson, J., Sage, H., Bornstein, P. J. Biol. Chem. (1981) [Pubmed]
  15. Improved sarcoma imaging and reduced hepatic activity with indium-111-SCN-Bz-DTPA linked to MoAb 19-24. Blend, M.J., Greager, J.A., Atcher, R.W., Brown, J.M., Brechbiel, M.W., Gansow, O.A., Das Gupta, T.K. J. Nucl. Med. (1988) [Pubmed]
  16. Effect of direct mail as a population-based strategy to increase mammography use among low-income underinsured women ages 40 to 64 years. Slater, J.S., Henly, G.A., Ha, C.N., Malone, M.E., Nyman, J.A., Diaz, S., McGovern, P.G. Cancer Epidemiol. Biomarkers Prev. (2005) [Pubmed]
  17. Characteristics of salivary profiles of oestradiol and progesterone in premenopausal women. Chatterton, R.T., Mateo, E.T., Hou, N., Rademaker, A.W., Acharya, S., Jordan, V.C., Morrow, M. J. Endocrinol. (2005) [Pubmed]
  18. Carnosic Acid and Carnosol, Phenolic Diterpene Compounds of the Labiate Herbs Rosemary and Sage, are Activators of the Human Peroxisome Proliferator-Activated Receptor Gamma. Rau, O., Wurglics, M., Paulke, A., Zitzkowski, J., Meindl, N., Bock, A., Dingermann, T., Abdel-Tawab, M., Schubert-Zsilavecz, M. Planta Med. (2006) [Pubmed]
  19. A new real-time drinking water network mixing model for the control and command centre of the city of Paris. Montiel, F., Coutelan, J., Nguyen, B. Water Sci. Technol. (2002) [Pubmed]
  20. Illness perceptions predict attendance at cardiac rehabilitation following acute myocardial infarction: A systematic review with meta-analysis. French, D.P., Cooper, A., Weinman, J. Journal of psychosomatic research (2006) [Pubmed]
  21. Free vascularised fibular grafts for congenital pseudarthrosis of the tibia. Simonis, R.B., Shirali, H.R., Mayou, B. The Journal of bone and joint surgery. British volume. (1991) [Pubmed]
  22. How well can children understand medicine related topics? Hämeen-Anttila, K., Juvonen, M., Ahonen, R., Bush, P.J., Airaksinen, M. Patient education and counseling. (2006) [Pubmed]
  23. A review of computer-aided body surface area determination: SAGE II and EPRI's 3D Burn Vision. Neuwalder, J.M., Sampson, C., Breuing, K.H., Orgill, D.P. The Journal of burn care & rehabilitation. (2002) [Pubmed]
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