Disease relevance of SAGE1

• The Lynn Sage Memorial Lecture: new developments in breast cancer management [1].
• A reliable quantitative microcytotoxicity technique is presented which demonstrates that: (1) osteosarcoma is not due to host immuno-incompetence, (2) a common sarcoma antigen does not exist and (3) serum blocking factors may occasionally be present [2].
• Toxicological studies carried out on aqueous extract of Salvia splendens commonly known as Red Sage reveals that the drug is toxic only in higher doses and causes hemorrhages [3].

High impact information on SAGE1

• Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4{alpha}SG1 and PH4{alpha}SG2 [4].
• Recently we have identified angiostatin, an endogenous angiogenesis inhibitor of 38 kDa which specifically blocks the growth of endothelial cells (O'Reilly, M. S., Holmgren, L., Shing, Y., Chen, C. , Rosenthal, R. A., Moses, M., Lane, W. S., Cao, Y., Sage, E. H., and Folkman, J. (1994) Cell 79, 315-328; Folkman, J. (1995) Nat. Med. 1, 27-31) [5].
• The selective ability of angiogenic endothelium to utilize the alpha 1(I)-collagen promoter is consistent with previous studies showing high levels of alpha 1(I)-collagen mRNA in BAE cells actively engaged in the formation of tubes (Iruela-Arispe, L., Hasselaar, P., and Sage, H. (1991) Lab. Invest. 64, 174-186) [6].
• The N-terminal amino acid sequence of human bone osteonectin was nearly identical to bovine bone osteonectin and had many similarities to a protein found in mouse parietal endoderm (Mason, I.J., Taylor, A., Williams, J.G., Sage, H., and Hogan, B.L.M. (1986) EMBO J [7].
• A murine monoclonal antibody (MAb 19-24) directed against a human sarcoma antigen was labeled with indium-111 (111In) by use of the linker 1-(p-isothiocyanatobenzyl)-diethylenetriaminepentaacetic acid (SCN-Bz-DTPA) [8].

Biological context of SAGE1

• Use of nonprohibited hallucinogenic plants: increasing relevance for public health? A case report and literature review on the consumption of Salvia divinorum (Diviner's Sage) [9].
• Type VIII collagen has been localized to specialized extracellular matrices in fetal tissues and has been suggested to be associated with cellular proliferation and angiogenesis (Sage and Iruela-Arispe 1990) [10].
• The relationship between social work and medical sociology is analyzed, utilizing case studies of an academic institution, Harvard University, and a private foundation, the Russell Sage Foundation. Both strongly supported social work during the first decades of the twentieth century, and both changed their focus to social science [11].

Anatomical context of SAGE1

• Sperm acrosomes were analyzed with the Spermac (Stain Enterprises, South Africa; distributed by Sage Biopharma, Bedminster, NJ) acrosome stain [12].
• 2. The granulosa cell element showed strong membrane staining of Ewing's sarcoma antigen 013 and the Sertoli cell element was locally positive [13].

Associations of SAGE1 with chemical compounds

• A high molecular weight glycoprotein, reported to be secreted by endothelial cells (Sage, H., Crouch, E., and Bornstein, P. (1979) Biochemistry 18, 5433-5442), has been purified to apparent homogeneity from culture medium of adult bovine aortic endothelial cells [14].
• A murine monoclonal antibody (MoAb 19-24) directed against a human sarcoma antigen was prepared and labeled with 111In by use of the linker 1-(p-isothiocyanatobenzyl)-diethylenetriaminepentaacetic acid (SCN-Bz-DTPA) [15].
• The Mail and Mail Plus Incentive interventions were estimated to produce increases in Sage screening rates of 0.23% and 0.75%, respectively, beyond the composite Control rate of 0.83% [16].
• The objective of the study was to characterize salivary sex steroid levels in 56 women undergoing annual mammography who were participating in a breast density study at the Lynn Sage Breast Center of Northwestern Memorial Hospital, and to determine the predictability of the patterns within women [17].
• Carnosic Acid and Carnosol, Phenolic Diterpene Compounds of the Labiate Herbs Rosemary and Sage, are Activators of the Human Peroxisome Proliferator-Activated Receptor Gamma [18].

Other interactions of SAGE1

• This diversity of origins of the water and the existence of a gridded network leads the company in charge of the production and the quality of the water in Paris, Sagep, to partly mix the water in the network [19].

Analytical, diagnostic and therapeutic context of SAGE1

• Direct mail is an effective strategy for increasing mammography use through Sage. Coupling direct mail with an incentive significantly enhances the intervention's effectiveness [16].
• METHODS: The strategy and procedures recommended by Hunter and Schmidt [Hunter JE, Schmidt FL. Methods of meta-analysis: correcting error and bias in research findings. Thousand Oaks (CA): Sage, 2004] were followed [20].
• For a small defect with a favourable prognosis (Boyd and Sage 1958), we recommend conventional bone grafting, intramedullary nailing and electrical stimulation [21].
• Both inductive and deductive analyses were used to analyse the data [Patton M. Qualitative evaluation and research methods. 2nd ed. Newbury Park: Sage Publications; 1990] [22].
• Members of our burn team found the Sage II program easy to use and found many of the features useful for patient care [23].

References