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Gene Review

Cpb2  -  carboxypeptidase B2 (plasma)

Mus musculus

Synonyms: 1110032P04Rik, 4930405E17Rik, AI255929, CPR, CPU, ...
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Disease relevance of Cpb2


High impact information on Cpb2


Chemical compound and disease context of Cpb2


Biological context of Cpb2


Anatomical context of Cpb2


Associations of Cpb2 with chemical compounds

  • Carboxypeptidase R (EC; CPR) and carboxypeptidase N (EC 3. 4.17.3; CPN) cleave carboxyl-terminal arginine and lysine residues from biologically active peptides such as kinins and anaphylatoxins, resulting in regulation of their biological activity [1].
  • Thrombin-activatable fibrinolysis inhibitor (TAFI) is a procarboxypeptidase that, after activation, can attenuate plasmin-mediated fibrin degradation by removing the C-terminal lysine residues from fibrin, which play a role in the binding and activation of plasminogen [11].

Regulatory relationships of Cpb2

  • Moreover, activated Akt induced the expression of TAFI mRNA to a similar extent by insulin in 3T3-L1 adipocytes expressing tamoxifen-regulatable Akt [9].

Other interactions of Cpb2


Analytical, diagnostic and therapeutic context of Cpb2

  • Bioassay showed that the CPU value of AngP1 was 0.01 microg/body ( approximately 30 mg) for the excitatory insect toxicity and 43.0% inhibition efficiency for analgesia at a dose of 5 mg/kg [12].


  1. Pro-carboxypeptidase R is an acute phase protein in the mouse, whereas carboxypeptidase N is not. Sato, T., Miwa, T., Akatsu, H., Matsukawa, N., Obata, K., Okada, N., Campbell, W., Okada, H. J. Immunol. (2000) [Pubmed]
  2. Tumor growth and metastasis are not affected in thrombin-activatable fibrinolysis inhibitor-deficient mice. Reijerkerk, A., Meijers, J.C., Havik, S.R., Bouma, B.N., Voest, E.E., Gebbink, M.F. J. Thromb. Haemost. (2004) [Pubmed]
  3. Thrombin-activatable fibrinolysis inhibitor (TAFI) deficiency is compatible with murine life. Nagashima, M., Yin, Z.F., Zhao, L., White, K., Zhu, Y., Lasky, N., Halks-Miller, M., Broze, G.J., Fay, W.P., Morser, J. J. Clin. Invest. (2002) [Pubmed]
  4. Thrombin-activatable fibrinolysis inhibitor deficiency attenuates bleomycin-induced lung fibrosis. Fujimoto, H., Gabazza, E.C., Taguchi, O., Nishii, Y., Nakahara, H., Bruno, N.E., D'Alessandro-Gabazza, C.N., Kasper, M., Yano, Y., Nagashima, M., Morser, J., Broze, G.J., Suzuki, K., Adachi, Y. Am. J. Pathol. (2006) [Pubmed]
  5. Murine model of ferric chloride-induced vena cava thrombosis: evidence for effect of potato carboxypeptidase inhibitor. Wang, X., Smith, P.L., Hsu, M.Y., Ogletree, M.L., Schumacher, W.A. J. Thromb. Haemost. (2006) [Pubmed]
  6. Protective role of thrombin activatable fibrinolysis inhibitor in obstructive nephropathy-associated tubulointerstitial fibrosis. Bruno, N.E., Yano, Y., Takei, Y., Gabazza, E.C., Qin, L., Nagashima, M., Morser, J., D'Alessandro-Gabazza, C.N., Taguchi, O., Sumida, Y. J. Thromb. Haemost. (2008) [Pubmed]
  7. Absence of procarboxypeptidase R induces complement-mediated lethal inflammation in lipopolysaccharide-primed mice. Asai, S., Sato, T., Tada, T., Miyamoto, T., Kimbara, N., Motoyama, N., Okada, H., Okada, N. J. Immunol. (2004) [Pubmed]
  8. Characterization of mouse thrombin-activatable fibrinolysis inhibitor. Marx, P.F., Wagenaar, G.T., Reijerkerk, A., Tiekstra, M.J., van Rossum, A.G., Gebbink, M.F., Meijers, J.C. Thromb. Haemost. (2000) [Pubmed]
  9. Insulin enhanced thrombin-activable fibrinolysis inhibitor expression through PI3 kinase/Akt pathway. Hori, Y., Nakatani, K., Morioka, K., Katsuki, A., Gabazza, E.C., Yano, Y., Nobori, T., Adachi, Y., Sumida, Y. Int. J. Mol. Med. (2005) [Pubmed]
  10. Protein A induced protection against experimental candidiasis in mice. Srivastava, A.K., Singh, K.P., Ray, P.K. Mycopathologia (1997) [Pubmed]
  11. Impaired healing of cutaneous wounds and colonic anastomoses in mice lacking thrombin-activatable fibrinolysis inhibitor. te Velde, E.A., Wagenaar, G.T., Reijerkerk, A., Roose-Girma, M., Borel Rinkes, I.H., Voest, E.E., Bouma, B.N., Gebbink, M.F., Meijers, J.C. J. Thromb. Haemost. (2003) [Pubmed]
  12. A new insect neurotoxin AngP1 with analgesic effect from the scorpion Buthus martensii Karsch: purification and characterization. Guan, R.J., Wang, M., Wang, D., Wang, D.C. J. Pept. Res. (2001) [Pubmed]
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