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Gene Review

Selplg  -  selectin, platelet (p-selectin) ligand

Mus musculus

Synonyms: CD162, P-selectin glycoprotein ligand 1, PSGL-1, Psgl-1, Psgl1, ...
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Disease relevance of Selplg


High impact information on Selplg


Chemical compound and disease context of Selplg


Biological context of Selplg


Anatomical context of Selplg


Associations of Selplg with chemical compounds


Physical interactions of Selplg


Regulatory relationships of Selplg


Other interactions of Selplg

  • We conclude that leukocyte-expressed PSGL-1 serves as the main L-selectin ligand in inflamed postcapillary venules [8].
  • Surface P-selectin glycoprotein ligand 1 (PSGL-1) and LFA-1 were up-regulated on both populations but were expressed at higher levels on Th1-like cells [22].
  • These results indicate that PSGL-1 is required for the early inflammatory responses but not for E-selectin-mediated responses [11].
  • In contrast, leukocyte rolling 2 h after tumor necrosis factor alpha stimulation was only modestly reduced, but blocking antibodies to E-selectin infused into the PSGL-1-deficient mouse almost completely eliminated leukocyte rolling [11].
  • Here, we demonstrate for the first time that P-selectin glycoprotein ligand-1 (PSGL-1) or CD162 molecules cross-linked by an anti-PSGL-1 monoclonal antibody, TAB4, can trigger a death signal in activated T cells [23].

Analytical, diagnostic and therapeutic context of Selplg


  1. Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Hrachovinová, I., Cambien, B., Hafezi-Moghadam, A., Kappelmayer, J., Camphausen, R.T., Widom, A., Xia, L., Kazazian, H.H., Schaub, R.G., McEver, R.P., Wagner, D.D. Nat. Med. (2003) [Pubmed]
  2. A down-regulatable E-selectin ligand is functionally important for PSGL-1-independent leukocyte-endothelial cell interactions. Zanardo, R.C., Bonder, C.S., Hwang, J.M., Andonegui, G., Liu, L., Vestweber, D., Zbytnuik, L., Kubes, P. Blood (2004) [Pubmed]
  3. Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum. Carlyon, J.A., Akkoyunlu, M., Xia, L., Yago, T., Wang, T., Cummings, R.D., McEver, R.P., Fikrig, E. Blood (2003) [Pubmed]
  4. Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. Falati, S., Liu, Q., Gross, P., Merrill-Skoloff, G., Chou, J., Vandendries, E., Celi, A., Croce, K., Furie, B.C., Furie, B. J. Exp. Med. (2003) [Pubmed]
  5. Essential role of P-selectin in the initiation of the inflammatory response induced by hemorrhage and reinfusion. Scalia, R., Armstead, V.E., Minchenko, A.G., Lefer, A.M. J. Exp. Med. (1999) [Pubmed]
  6. Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis. Rivera-Nieves, J., Burcin, T.L., Olson, T.S., Morris, M.A., McDuffie, M., Cominelli, F., Ley, K. J. Exp. Med. (2006) [Pubmed]
  7. 6-Sulfo LacNAc, a novel carbohydrate modification of PSGL-1, defines an inflammatory type of human dendritic cells. Schäkel, K., Kannagi, R., Kniep, B., Goto, Y., Mitsuoka, C., Zwirner, J., Soruri, A., von Kietzell, M., Rieber, E. Immunity (2002) [Pubmed]
  8. P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules. Sperandio, M., Smith, M.L., Forlow, S.B., Olson, T.S., Xia, L., McEver, R.P., Ley, K. J. Exp. Med. (2003) [Pubmed]
  9. PSGL-1 is not required for development of experimental autoimmune encephalomyelitis. Osmers, I., Bullard, D.C., Barnum, S.R. J. Neuroimmunol. (2005) [Pubmed]
  10. Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor. Yang, J., Galipeau, J., Kozak, C.A., Furie, B.C., Furie, B. Blood (1996) [Pubmed]
  11. Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration. Yang, J., Hirata, T., Croce, K., Merrill-Skoloff, G., Tchernychev, B., Williams, E., Flaumenhaft, R., Furie, B.C., Furie, B. J. Exp. Med. (1999) [Pubmed]
  12. Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1. Winkler, I.G., Snapp, K.R., Simmons, P.J., Lévesque, J.P. Blood (2004) [Pubmed]
  13. IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules. Underhill, G.H., Minges Wols, H.A., Fornek, J.L., Witte, P.L., Kansas, G.S., Minges-Wols, H.A. Blood (2002) [Pubmed]
  14. Rolling of Th1 cells via P-selectin glycoprotein ligand-1 stimulates LFA-1-mediated cell binding to ICAM-1. Atarashi, K., Hirata, T., Matsumoto, M., Kanemitsu, N., Miyasaka, M. J. Immunol. (2005) [Pubmed]
  15. P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo. Norman, K.E., Katopodis, A.G., Thoma, G., Kolbinger, F., Hicks, A.E., Cotter, M.J., Pockley, A.G., Hellewell, P.G. Blood (2000) [Pubmed]
  16. Expression and function of P-selectin glycoprotein ligand 1 (CD162) on human basophils. Taylor, M.L., Brummet, M.E., Hudson, S.A., Miura, K., Bochner, B.S. J. Allergy Clin. Immunol. (2000) [Pubmed]
  17. P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. Xia, L., Sperandio, M., Yago, T., McDaniel, J.M., Cummings, R.D., Pearson-White, S., Ley, K., McEver, R.P. J. Clin. Invest. (2002) [Pubmed]
  18. P-selectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyltransferases Fuc-TIV and Fuc-TVII in mouse neutrophils. Huang, M.C., Zöllner, O., Moll, T., Maly, P., Thall, A.D., Lowe, J.B., Vestweber, D. J. Biol. Chem. (2000) [Pubmed]
  19. L- and P-selectins collaborate to support leukocyte rolling in vivo when high-affinity P-selectin-P-selectin glycoprotein ligand-1 interaction is inhibited. Ridger, V.C., Hellewell, P.G., Norman, K.E. Am. J. Pathol. (2005) [Pubmed]
  20. Peritoneal macrophages express both P-selectin and PSGL-1. Tchernychev, B., Furie, B., Furie, B.C. J. Cell Biol. (2003) [Pubmed]
  21. P-Selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration. Hirata, T., Merrill-Skoloff, G., Aab, M., Yang, J., Furie, B.C., Furie, B. J. Exp. Med. (2000) [Pubmed]
  22. Recruitment of IFN-gamma-producing (Th1-like) cells into the inflamed retina in vivo is preferentially regulated by P-selectin glycoprotein ligand 1:P/E-selectin interactions. Xu, H., Manivannan, A., Jiang, H.R., Liversidge, J., Sharp, P.F., Forrester, J.V., Crane, I.J. J. Immunol. (2004) [Pubmed]
  23. Cross-linking of P-selectin glycoprotein ligand-1 induces death of activated T cells. Chen, S.C., Huang, C.C., Chien, C.L., Jeng, C.J., Su, H.T., Chiang, E., Liu, M.R., Wu, C.H., Chang, C.N., Lin, R.H. Blood (2004) [Pubmed]
  24. Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1. Rossi, F.M., Corbel, S.Y., Merzaban, J.S., Carlow, D.A., Gossens, K., Duenas, J., So, L., Yi, L., Ziltener, H.J. Nat. Immunol. (2005) [Pubmed]
  25. Stimulation of P-selectin glycoprotein ligand-1 on mouse neutrophils activates beta 2-integrin mediated cell attachment to ICAM-1. Blanks, J.E., Moll, T., Eytner, R., Vestweber, D. Eur. J. Immunol. (1998) [Pubmed]
  26. Blockade of CD49d inhibits allergic airway pathologies independent of effects on leukocyte recruitment. Borchers, M.T., Crosby, J., Farmer, S., Sypek, J., Ansay, T., Lee, N.A., Lee, J.J. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
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