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MeSH Review

Diet, Atherogenic

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Disease relevance of Diet, Atherogenic


High impact information on Diet, Atherogenic


Chemical compound and disease context of Diet, Atherogenic


Biological context of Diet, Atherogenic


Anatomical context of Diet, Atherogenic


Associations of Diet, Atherogenic with chemical compounds


Gene context of Diet, Atherogenic

  • Thus, in response to the atherogenic diet there is an early increase in liver CETP mRNA, probably causing increased CETP synthesis and secretion, and increased plasma CETP [30].
  • On an atherogenic diet, PON activity decreased by 52%, and apoJ levels increased 2.8-fold in fatty streak susceptible mice, C57BL/6J (BL/6), but not in fatty streak resistant mice, C3H/HeJ (C3H) [31].
  • To address the role of LPL in atherosclerosis, LPL+/- mice in the C57BL/6J background were fed an atherogenic diet for 8 months [4].
  • Apolipoprotein J (apoJ), a glycoprotein associated with subclasses of plasma high density lipoproteins (HDL), was found to accumulate in aortic lesions in a human subject with transplantation-associated arteriosclerosis and in mice fed a high-fat atherogenic diet [32].
  • The VLDLR mRNA expression was down-regulated 3-fold by feeding atherogenic diet in heart and skeletal muscle only in LDLR-/- mice [33].

Analytical, diagnostic and therapeutic context of Diet, Atherogenic


  1. Hemodynamic sequelae of regression of experimental atherosclerosis. Armstrong, M.L., Heistad, D.D., Marcus, M.L., Piegors, D.J., Abboud, F.M. J. Clin. Invest. (1983) [Pubmed]
  2. Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization. Aikawa, M., Rabkin, E., Okada, Y., Voglic, S.J., Clinton, S.K., Brinckerhoff, C.E., Sukhova, G.K., Libby, P. Circulation (1998) [Pubmed]
  3. Inhibition of coronary atherosclerosis by propranolol in behaviorally predisposed monkeys fed an atherogenic diet. Kaplan, J.R., Manuck, S.B., Adams, M.R., Weingand, K.W., Clarkson, T.B. Circulation (1987) [Pubmed]
  4. Effects of heterozygous lipoprotein lipase deficiency on diet-induced atherosclerosis in mice. Semenkovich, C.F., Coleman, T., Daugherty, A. J. Lipid Res. (1998) [Pubmed]
  5. Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice. van Ree, J.H., van den Broek, W.J., Dahlmans, V.E., Groot, P.H., Vidgeon-Hart, M., Frants, R.R., Wieringa, B., Havekes, L.M., Hofker, M.H. Atherosclerosis (1994) [Pubmed]
  6. Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI. Rubin, E.M., Krauss, R.M., Spangler, E.A., Verstuyft, J.G., Clift, S.M. Nature (1991) [Pubmed]
  7. Endogenous cyclic adenosine monophosphate in tissues of rabbits fed an atherogenic diet. Augustyn, J.M., Ziegler, F.D. Science (1975) [Pubmed]
  8. Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. Moore, K.J., Kunjathoor, V.V., Koehn, S.L., Manning, J.J., Tseng, A.A., Silver, J.M., McKee, M., Freeman, M.W. J. Clin. Invest. (2005) [Pubmed]
  9. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo. Babaev, V.R., Fazio, S., Gleaves, L.A., Carter, K.J., Semenkovich, C.F., Linton, M.F. J. Clin. Invest. (1999) [Pubmed]
  10. A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. Boisvert, W.A., Santiago, R., Curtiss, L.K., Terkeltaub, R.A. J. Clin. Invest. (1998) [Pubmed]
  11. Lovastatin inhibits diet induced atherosclerosis in F1B golden Syrian hamsters. Otto, J., Ordovas, J.M., Smith, D., van Dongen, D., Nicolosi, R.J., Schaefer, E.J. Atherosclerosis (1995) [Pubmed]
  12. Effect of pravastatin on left ventricular mass by activation of myocardial K ATP channels in hypercholesterolemic rabbits. Lee, T.M., Lin, M.S., Chou, T.F., Tsai, C.H., Chang, N.C. Atherosclerosis (2004) [Pubmed]
  13. High-dose synthetic progestogens inhibit foam and smooth muscle cell proliferation and atherosclerotic plaque formation in aortas of rabbits fed a hypercholesterolemic diet. Spagnoli, L.G., Palmieri, G., Mauriello, A., Orlandi, A., Bancheri, C., Pasetto, N. Atherosclerosis (1990) [Pubmed]
  14. Efficacy of hypolipidemic treatment in inhibition of experimental atherosclerosis: the effect of nicotinic acid and related compounds. Parwaresch, M.R., Haacke, H., Mäder, C. Atherosclerosis (1978) [Pubmed]
  15. Effect of simvastatin on left ventricular mass in hypercholesterolemic rabbits. Lee, T.M., Lin, M.S., Chou, T.F., Chang, N.C. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  16. Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism. Machleder, D., Ivandic, B., Welch, C., Castellani, L., Reue, K., Lusis, A.J. J. Clin. Invest. (1997) [Pubmed]
  17. Quantitative trait locus analysis of plasma lipoprotein levels in an autoimmune mouse model : interactions between lipoprotein metabolism, autoimmune disease, and atherogenesis. Gu, L., Johnson, M.W., Lusis, A.J. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  18. Excessive dietary tryptophan enhances plasma lipid peroxidation in rats. Aviram, M., Cogan, U., Mokady, S. Atherosclerosis (1991) [Pubmed]
  19. The effects of diet and lovastatin on regression of fatty streak lesions and on hepatic and intestinal mRNA levels for the LDL receptor and HMG CoA reductase in F1B hamsters. Pitman, W.A., Osgood, D.P., Smith, D., Schaefer, E.J., Ordovas, J.M. Atherosclerosis (1998) [Pubmed]
  20. Inhibition of cholesterol-induced atherosclerosis in rabbits by dimethyl sulfoxide. Debons, A.F., Fani, K., Jimenez, F.A., Maayan, M.L. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  21. Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E. Osuga, J., Yonemoto, M., Yamada, N., Shimano, H., Yagyu, H., Ohashi, K., Harada, K., Kamei, T., Yazaki, Y., Ishibashi, S. J. Clin. Invest. (1998) [Pubmed]
  22. The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation. Hajra, L., Evans, A.I., Chen, M., Hyduk, S.J., Collins, T., Cybulsky, M.I. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  23. Blocking very late antigen-4 integrin decreases leukocyte entry and fatty streak formation in mice fed an atherogenic diet. Shih, P.T., Brennan, M.L., Vora, D.K., Territo, M.C., Strahl, D., Elices, M.J., Lusis, A.J., Berliner, J.A. Circ. Res. (1999) [Pubmed]
  24. Immunolocalization of proteoglycan types in aortas of pigeons with spontaneous or diet-induced artherosclerosis. Robbins, R.A., Wagner, W.D., Sawyer, L.M., Caterson, B. Am. J. Pathol. (1989) [Pubmed]
  25. Increased activity of intestinal acyl-CoA: cholesterol acyltransferase in rats with streptozocin-induced diabetes and restoration by insulin supplementation. Jiao, S., Matsuzawa, Y., Matsubara, K., Kihara, S., Nakamura, T., Tokunaga, K., Kubo, M., Tarui, S. Diabetes (1988) [Pubmed]
  26. Hydrophobic surfactant treatment prevents atherosclerosis in the rabbit. Rodgers, J.B., Kyriakides, E.C., Kapuscinska, B., Peng, S.K., Bochenek, W.J. J. Clin. Invest. (1983) [Pubmed]
  27. Paradoxical enhancement of atherosclerosis by probucol treatment in apolipoprotein E-deficient mice. Zhang, S.H., Reddick, R.L., Avdievich, E., Surles, L.K., Jones, R.G., Reynolds, J.B., Quarfordt, S.H., Maeda, N. J. Clin. Invest. (1997) [Pubmed]
  28. Regulation of intestinal and hepatic apoprotein synthesis after chronic fat and cholesterol feeding. Go, M.F., Schonfeld, G., Pfleger, B., Cole, T.G., Sussman, N.L., Alpers, D.H. J. Clin. Invest. (1988) [Pubmed]
  29. Suppression of calcific fibrous-fatty plaque formation in rabbits by agents not affecting elevated serum cholesterol levels. The effect of thiophene compounds. Chan, C.T., Wells, H., Kramsch, D.M. Circ. Res. (1978) [Pubmed]
  30. Atherogenic diet increases cholesteryl ester transfer protein messenger RNA levels in rabbit liver. Quinet, E.M., Agellon, L.B., Kroon, P.A., Marcel, Y.L., Lee, Y.C., Whitlock, M.E., Tall, A.R. J. Clin. Invest. (1990) [Pubmed]
  31. Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio. Navab, M., Hama-Levy, S., Van Lenten, B.J., Fonarow, G.C., Cardinez, C.J., Castellani, L.W., Brennan, M.L., Lusis, A.J., Fogelman, A.M., La Du, B.N. J. Clin. Invest. (1997) [Pubmed]
  32. Mouse apolipoprotein J: characterization of a gene implicated in atherosclerosis. Jordan-Starck, T.C., Lund, S.D., Witte, D.P., Aronow, B.J., Ley, C.A., Stuart, W.D., Swertfeger, D.K., Clayton, L.R., Sells, S.F., Paigen, B. J. Lipid Res. (1994) [Pubmed]
  33. Mouse very low-density lipoprotein receptor (VLDLR): gene structure, tissue-specific expression and dietary and developmental regulation. Tiebel, O., Oka, K., Robinson, K., Sullivan, M., Martinez, J., Nakamuta, M., Ishimura-Oka, K., Chan, L. Atherosclerosis (1999) [Pubmed]
  34. Inhibition of postmenopausal atherosclerosis progression: a comparison of the effects of conjugated equine estrogens and soy phytoestrogens. Clarkson, T.B., Anthony, M.S., Morgan, T.M. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  35. ApoA1 reduces free cholesterol accumulation in atherosclerotic lesions of ApoE-deficient mice transplanted with ApoE-expressing macrophages. Boisvert, W.A., Black, A.S., Curtiss, L.K. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  36. Raloxifene and estrogen reduces progression of advanced atherosclerosis--a study in ovariectomized, cholesterol-fed rabbits. Bjarnason, N.H., Haarbo, J., Byrjalsen, I., Alexandersen, P., Kauffman, R.F., Christiansen, C. Atherosclerosis (2001) [Pubmed]
  37. Lipid deposition in the aorta of adjuvant arthritic rats with hypercholesterolemia. Kunitomo, M., Yamaguchi, Y., Futagawa, Y., Hamaguchi, Y., Bandô, Y. Jpn. J. Pharmacol. (1986) [Pubmed]
  38. Role of circulating immune complexes and platelet aggregation in the development of experimentally induced atherosclerosis in monkeys with normal intact vas deferens and following vasectomy. Sharda, N., Dhawan, V., Bansal, N., Ganguly, N.K., Majumdar, S., Chakravarti, R.N. Indian heart journal. (1991) [Pubmed]
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