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Gene Review

EXOSC7  -  exosome component 7

Homo sapiens

Synonyms: EAP1, Exosome complex component RRP42, Exosome component 7, KIAA0116, RRP42, ...
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Disease relevance of EXOSC7

  • However, the expression of p8 in pancreatic cancer is not reported [1].
  • The p8 gene is a recently identified gene with mitogenic activity. p8 expression is induced in acute pancreatitis, pancreatic development, and regeneration [1].
  • We investigated p8 expression in 72 human pancreatic tissues, including 38 pancreatic cancers (PCs), by immunohistochemistry. p8 was overexpressed (positive cells >25% in 1,000 cells) in 71% (27 of 38) of PCs, but in only 17% (3 of 18) of chronic pancreatitis cases [1].
  • On the other hand, p8 localization was more cytoplasmic in papillary carcinoma larger than 1.0 cm (p=0.0186) and with a poorly differentiated lesion (p=0.0313) [2].
  • All non-invasive ductal carcinomas diffusely expressed p8 [3].

High impact information on EXOSC7


Biological context of EXOSC7

  • We demonstrate that the two human proteins hCsl4p and hRrp42p, which have been identified on the basis of their sequence homology with Saccharomyces cerevisiae proteins, are associated with the human exosome [7].
  • The p8 gene comprises three exons separated by two introns and the gene was mapped to chromosome 16 [8].
  • To analyze the p8 function, we stably transfected HeLa cells with a p8 expression plasmid, and measured their growth and their sensitivity to apoptosis [8].
  • This presumption has been confirmed by transfection of COS-7 cells with the p8 cDNA followed by immunostaining with specific antibodies. p8 mRNA expression is induced in some, but not all, cells by serum starvation and ceramide [8].
  • p8 is a widely expressed HMG-I/Y-like transcription factor which is involved in regulating cell proliferation and tissue stress [9].

Anatomical context of EXOSC7

  • Reverse transcription-PCR analysis confirmed p8 mRNA overexpression (tumor/nontumor ratio >2) in 75% (3 of 4) of PCs. p8 was overexpressed also in human pancreatic cancer cell lines (MIA PaCa-2 and PANC-1) [1].
  • We have previously identified a new rat mRNA, provisionally named p8, which showed a strong, but transient, induction in the pancreas in response to acute pancreatitis [8].
  • Expression and cellular localization of p8 protein in thyroid neoplasms [2].
  • The p8 expression level was directly linked to lymph node metastasis, extrathyroid extension and UICC stage [10].
  • Subcutaneous or intraperitoneal injections of transformed p8-expressing fibroblasts led to tumor formation in nude mice, but no tumor was observed with transformed p8-deficient cells [11].

Associations of EXOSC7 with chemical compounds

  • We found that (a) knocking down p8 expression in gemcitabine-resistant cells promoted cell death and increased caspase-3 activity; (b) forced overexpression of p8 in gemcitabine-sensitive cells increased their resistance to gemcitabine-induced apoptosis; and (c) gemcitabine down-regulated p8 mRNA expression [6].
  • Characterization of glutathione S-transferase from dust mite, Der p 8 and its immunoglobulin E cross-reactivity with cockroach glutathione S-transferase [12].

Other interactions of EXOSC7


Analytical, diagnostic and therapeutic context of EXOSC7

  • IgE reactivity to native and recombinant Der p 8 was assessed by ELISA using sera from allergic subjects from Taiwan, Singapore and Malaysia. IgE cross-reactivity between Der p 8 and cockroach GST was examined by IgE inhibition assays [12].


  1. Expression of p8 in human pancreatic cancer. Su, S.B., Motoo, Y., Iovanna, J.L., Xie, M.J., Mouri, H., Ohtsubo, K., Yamaguchi, Y., Watanabe, H., Okai, T., Matsubara, F., Sawabu, N. Clin. Cancer Res. (2001) [Pubmed]
  2. Expression and cellular localization of p8 protein in thyroid neoplasms. Ito, Y., Yoshida, H., Motoo, Y., Miyoshi, E., Iovanna, J.L., Tomoda, C., Uruno, T., Takamura, Y., Miya, A., Kobayashi, K., Matsuzuka, F., Matsuura, N., Kuma, K., Miyauchi, A. Cancer Lett. (2003) [Pubmed]
  3. Expression of p8 protein in breast carcinoma; an inverse relationship with apoptosis. Ito, Y., Yoshida, H., Motoo, Y., Iovanna, J.L., Nakamura, Y., Kakudo, K., Uruno, T., Takamura, Y., Miya, A., Noguchi, S., Kuma, K., Miyauchi, A. Anticancer Res. (2005) [Pubmed]
  4. Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. Tang, Y., Hu, L.A., Miller, W.E., Ringstad, N., Hall, R.A., Pitcher, J.A., DeCamilli, P., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  5. Translocation of a small cytosolic calcium-binding protein (MRP-8) to plasma membrane correlates with human neutrophil activation. Lemarchand, P., Vaglio, M., Mauël, J., Markert, M. J. Biol. Chem. (1992) [Pubmed]
  6. p8 is a new target of gemcitabine in pancreatic cancer cells. Giroux, V., Malicet, C., Barthet, M., Gironella, M., Archange, C., Dagorn, J.C., Vasseur, S., Iovanna, J.L. Clin. Cancer Res. (2006) [Pubmed]
  7. Protein-protein interactions of hCsl4p with other human exosome subunits. Raijmakers, R., Noordman, Y.E., van Venrooij, W.J., Pruijn, G.J. J. Mol. Biol. (2002) [Pubmed]
  8. Cloning and expression of the human p8, a nuclear protein with mitogenic activity. Vasseur, S., Vidal Mallo, G., Fiedler, F., Bödeker, H., Cánepa, E., Moreno, S., Iovanna, J.L. Eur. J. Biochem. (1999) [Pubmed]
  9. Tumor Necrosis Factor Alpha Induces the Expression of the Nuclear Protein p8 via a Novel NFkappaB Binding Site within the Promoter. Kallwellis, K., Grempler, R., Günther, S., Päth, G., Walther, R. Horm. Metab. Res. (2006) [Pubmed]
  10. Expression of p8 protein in medullary thyroid carcinoma. Ito, Y., Yoshida, H., Motoo, Y., Iovanna, J.L., Tomoda, C., Uruno, T., Takamura, Y., Miya, A., Kobayashi, K., Matsuzuka, F., Kuma, K., Miyauchi, A. Anticancer Res. (2005) [Pubmed]
  11. Expression of the stress-associated protein p8 is a requisite for tumor development. Iovanna, J.L. International journal of gastrointestinal cancer. (2002) [Pubmed]
  12. Characterization of glutathione S-transferase from dust mite, Der p 8 and its immunoglobulin E cross-reactivity with cockroach glutathione S-transferase. Huang, C.H., Liew, L.M., Mah, K.W., Kuo, I.C., Lee, B.W., Chua, K.Y. Clin. Exp. Allergy (2006) [Pubmed]
  13. Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. Brouwer, R., Vree Egberts, W.T., Hengstman, G.J., Raijmakers, R., van Engelen, B.G., Seelig, H.P., Renz, M., Mierau, R., Genth, E., Pruijn, G.J., van Venrooij, W.J. Arthritis Res. (2002) [Pubmed]
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