Disease relevance of EP400

• When P400 was infused in undernourished subjects without oral intake, balances of N, P, Mg, and Ca/70 kg of body weight per day were strongly negative (-4 g, -0.4 g, -6 mEq, and -0.2 g, respectively), whereas balances of K were about zero and those of Na and Cl were positive [1].

Psychiatry related information on EP400

• The P400 in REM sleep showed larger amplitudes in the ATTENTIVE condition, whereas the P200 amplitude did not differ between the 2 conditions [2].
• The amplitude and latency of the parietal P400 and the frontocentral negativity preceding P400 varied significantly with set size, but only between M1 and M2, whereas reaction time increased dramatically from M1 to M2 and from M2 to M4 [3].
• Results indicate that for the early Alzheimer's Disease group, a significant main effect for memory load was found for the P400 amplitude (F(3,30)=4.52, P<0.02) which was absent in the normal group [4].
• An early P3 subcomponent (P315) was larger in patients having an anxiety disorder alone when compared to depressed patients with or without an anxiety disorder and healthy controls, whereas a late P3 subcomponent (P400) was larger in patients having comorbidity of anxiety and depressive disorders than in the other groups [5].

High impact information on EP400

• P400, inositol 1,4,5-trisphosphate receptor (InsP3-R), is a key protein to understanding the mechanisms of inositol 1,4,5-trisphosphate (InsP3)-mediated Ca2+ mobilization [6].
• Expressed cerebellar-type inositol 1,4,5-trisphosphate receptor, P400, has calcium release activity in a fibroblast L cell line [6].
• In membranes, this protein displays high affinity, specificity, and capacity for InsP3, as does the cerebellar P400/InsP3-R [6].
• We show here that Tip60 and the E1A-associated p400 protein (EP400), which belongs to the Tip60 complex, are also required for DNA damage-induced apoptosis [7].
• Preliminary studies showed that when 5 mg of cortisol/liter were added to P900, this fluid could be infused through peripheral veins for as long a time (average 114 hr) as P400 before local reaction necessitated changing the site [1].

Biological context of EP400

• The present study was undertaken to examine possible changes in subjective appraisal and central nervous system processing, indexed by pain-related cerebral evoked potentials (N290, P400), of incoming noxious information in 20 pain-free control volunteers and 18 subjects suffering from right-side cervico-brachial pain (CBS) [8].
• It was found that N160 measures were larger, and P240, P400, and SW measures were smaller to words presented in the contralateral visual field compared to words in the ipsilateral field [9].
• Over the occipital regions, the emergence of major positivities at P400 and P650 were observed beginning around 120 days gestation [10].
• Stimuli just above the threshold elicited a distinct somatosensory evoked potential with components P50, P100, N190 and P400 [11].

Anatomical context of EP400

• Although a small number of P400/IP3R-positive Purkinje cells in OPCA were similar to the normal ones, the immunoreaction products in OPCA Purkinje cells disappeared from the dendritic spines and spiny branchlets toward the cell bodies [12].
• The cell bodies, axons and dendrites including spiny branchlets and dendritic spines of normal Purkinje cells were intensely stained by the antibody against P400 glycoprotein/inositol 1,4,5-trisphosphate receptor protein (P400/IP3R) [12].
• By contrast, the staining pattern of the Purkinje cells of gc-CD case was uniform: almost all the Purkinje cells expressed P400/IP3R in cell bodies, axons and dendrites, but not in the dendritic spines and spiny branchlets [12].

Associations of EP400 with chemical compounds

• The results showed that the combination T 100 + P 400 had better analgesic effects than the double dose of tolmetin, T 200, alone, while the effects of P 400 could not be discrminated from placebo [13].

References