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Chemical Compound Review

Tolectin     2-[1-methyl-5-(4- methylphenyl)carbonyl...

Synonyms: tolmetin, Tolmetina, Tolmetine, Tolmetino, Tolmetinum, ...
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Disease relevance of tolmetin


High impact information on tolmetin


Chemical compound and disease context of tolmetin


Biological context of tolmetin


Anatomical context of tolmetin

  • The average half-lives of tolmetin in plasma and synovial fluid were 6.77 +/- 1.47 hr and 6.90 +/- 2.3 hr [17].
  • Distribution of tolmetin in the whole blood of 8 healthy subjects using a centrifugation technique showed that the drug was not taken up by red blood cells at therapeutic concentrations [20].
  • 6 From these results, it is concluded that the site of anti-writhing action of tolmetin sodium is in the peritoneum and that tolmetin sodium produces its anti-writhing action mainly by a peripheral mechanism in the rat [21].
  • 3 When the rat was given tolmetin sodium 5 mg/kg orally, a relatively large quantity of tolmetin was found in the peritoneal exudate and there was a rough correlation between anti-writhing activity and the exudate tolmetin content [21].
  • This normalization of T-cell function by tolmetin was associated with clinical improvement [22].

Associations of tolmetin with other chemical compounds


Gene context of tolmetin


Analytical, diagnostic and therapeutic context of tolmetin


  1. Anaphylaxis from tolmetin. Ahmad, S. N. Engl. J. Med. (1980) [Pubmed]
  2. Tolmetin and agranulocytosis. Sakai, J., Joseph, M.W. N. Engl. J. Med. (1978) [Pubmed]
  3. Nephrotic syndrome induced by tolmetin. Chatterjee, G.P. JAMA (1981) [Pubmed]
  4. Tolmetin. Association with reversible renal failure and acute interstitial nephritis. Katz, S.M., Capaldo, R., Everts, E.A., DiGregorio, J.G. JAMA (1981) [Pubmed]
  5. Tolmetin-induced aseptic meningitis. Ruppert, G.B., Barth, W.F. JAMA (1981) [Pubmed]
  6. New antirheumatic agents: Fenoprofen calcium (Nalfon), naproxen (Naprosyn), and tolmetin sodium (Tolectin). Lewis, J.R. JAMA (1977) [Pubmed]
  7. Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry. Ding, A., Ojingwa, J.C., McDonagh, A.F., Burlingame, A.L., Benet, L.Z. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  8. Proteinuria associated with tolmetin treatment in a patient with systemic lupus erythematosus. Vogelgesang, S.A., Dennis, G.J., Bauer, F.A. Arthritis Rheum. (1993) [Pubmed]
  9. Tolmetin-induced thrombocytopenia. Lockhart, J.M. Arthritis Rheum. (1982) [Pubmed]
  10. Enhanced covalent binding of tolmetin to proteins in humans after multiple dosing. Zia-Amirhosseini, P., Ojingwa, J.C., Spahn-Langguth, H., McDonagh, A.F., Benet, L.Z. Clin. Pharmacol. Ther. (1994) [Pubmed]
  11. Effects of ibuprofen, tolmetin and placebo on the gastric mucosa of aspirin-sensitive volunteers. Lanza, F.L., Nelson, R.S., Royer, G.L. Am. J. Gastroenterol. (1979) [Pubmed]
  12. Effect of tolmetin glycine amide (McN-4366), a prodrug of tolmetin sodium, on adjuvant arthritis in the rat. Persico, F.J., Pritchard, J.F., Fisher, M.C., Yorgey, K., Wong, S., Carson, J. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  13. A double-blind comparative evaluation of tolmetin versus naproxen in osteoarthritis. Telhag, H., Bach-Andersen, R., Persson, B. Current medical research and opinion. (1981) [Pubmed]
  14. Non-steroidal anti-inflammatory agents, tolmetin and sulindac, inhibit liver tryptophan 2,3-dioxygenase activity and alter brain neurotransmitter levels. Dairam, A., Antunes, E.M., Saravanan, K.S., Daya, S. Life Sci. (2006) [Pubmed]
  15. Calcium-and G-protein-related spasmolytic effects of nonsteroidal anti-inflammatory drugs on rat uterus contractions in vitro. Pérez Vallina, J.R., Cantabrana, B., Hidalgo, A. Pharmacology (1995) [Pubmed]
  16. Disposition and irreversible plasma protein binding of tolmetin in humans. Hyneck, M.L., Smith, P.C., Munafo, A., McDonagh, A.F., Benet, L.Z. Clin. Pharmacol. Ther. (1988) [Pubmed]
  17. Tolmetin kinetics and synovial fluid prostaglandin E levels in rheumatoid arthritis. Dromgoole, S.H., Furst, D.E., Desiraju, R.K., Nayak, R.K., Kirschenbaum, M.A., Paulus, H.E. Clin. Pharmacol. Ther. (1982) [Pubmed]
  18. Absorption and excretion of tolmetin in arthritic patients. Grindel, J.M., Migdalof, B.H., Plostnieks, J. Clin. Pharmacol. Ther. (1979) [Pubmed]
  19. Effects of nonsteroidal anti-inflammatory drugs (NSAID) on renal excretion of sodium and water, and on body fluid volume in rats. Kadokawa, T., Hosoki, K., Takeyama, K., Minato, H., Shimizu, M. J. Pharmacol. Exp. Ther. (1979) [Pubmed]
  20. Protein binding of tolmetin. Selley, M.L., Madsen, B.W., Thomas, J. Clin. Pharmacol. Ther. (1978) [Pubmed]
  21. Site of analgesic action of a non-steroidal, anti-inflammatory drug, tolmetin sodium, in rats. Nakamura, H., Shimizu, M. Br. J. Pharmacol. (1981) [Pubmed]
  22. Enhancement of deficient T-cell function in rheumatoid arthritis by tolmetin sodium. Levy, J. Journal of clinical pharmacology. (1983) [Pubmed]
  23. Drugs and gastric damage. Cooke, A.R. Drugs (1976) [Pubmed]
  24. Displacement of valproic acid and carbamazepine from protein binding in normal and uremic sera by tolmetin, ibuprofen, and naproxen: presence of inhibitor in uremic serum that blocks valproic acid-naproxen interactions. Dasgupta, A., Volk, A. Therapeutic drug monitoring. (1996) [Pubmed]
  25. Non-steroidal anti-inflammatory agents, tolmetin and sulindac, attenuate oxidative stress in rat brain homogenate and reduce quinolinic acid-induced neurodegeneration in rat hippocampal neurons. Dairam, A., Chetty, P., Daya, S. Metabolic brain disease (2006) [Pubmed]
  26. A crossover study of naproxen, diclofenac and tolmetin in seronegative juvenile chronic arthritis. Leak, A.M., Richter, M.R., Clemens, L.E., Hall, M.A., Ansell, B.M. Clinical and experimental rheumatology. (1988) [Pubmed]
  27. Prostaglandin levels in seminal plasma and sperm extracts of the domestic turkey, and the effects of cyclooxygenase inhibitors on sperm mobility. Kennedy, J.H., Korn, N., Thurston, R.J. Reprod. Biol. Endocrinol. (2003) [Pubmed]
  28. Gastrointestinal and hepatic toxicity of selective and non-selective cyclooxygenase-2 inhibitors in pregnant and non-pregnant rats. Burdan, F., Szumilo, J., Klepacz, R., Dudka, J., Korobowicz, A., Tokarska, E., Cendrowska-Pinkosz, M., Madej, B., Klepacz, L. Pharmacol. Res. (2004) [Pubmed]
  29. Clinical use of tolmetin sodium in patients with ankylosing spondylitis: a review. Calin, A. Journal of clinical pharmacology. (1983) [Pubmed]
  30. Pharmacokinetic studies of tolmetin in man. Selley, M.L., Glass, J., Triggs, E.J., Thomas, J. Clin. Pharmacol. Ther. (1975) [Pubmed]
  31. Tolmetin-induced hemolysis. Squires, J.E., Mintz, P.D., Clark, S. Transfusion (1985) [Pubmed]
  32. Tolmetin sodium, a new anti-arthritis drug: double-blind and long-term studies. Cordrey, L.J. Journal of the American Geriatrics Society. (1976) [Pubmed]
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