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Gene Review

Ezr  -  ezrin

Mus musculus

Synonyms: AW146364, Cytovillin, Ezrin, R75297, Vil2, ...
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Disease relevance of Vil2


High impact information on Vil2

  • From this genomic data, we selected ezrin for further study based on its role in physically and functionally connecting the actin cytoskeleton to the cell membrane [2].
  • The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis [2].
  • ICAM-2 redistributed by ezrin as a target for killer cells [5].
  • Newly discovered cryptic actin-binding sites in vinculin and ezrin, two proteins recruited to adhesion sites, suggest that actin-binding proteins are targets for the signals generated by adhesion receptors [6].
  • In vivo, blockade of ezrin leads to enhanced transplanted EC proliferation and angiogenesis in a mouse hind limb ischemia model [7].

Chemical compound and disease context of Vil2


Biological context of Vil2


Anatomical context of Vil2


Associations of Vil2 with chemical compounds

  • Subcellular analysis demonstrated ezrin in fine filopodial structures in astrocytes, while merlin was detected in neuronal synaptic junctions [16].
  • More interestingly, treatment with SB203580 induced elongation of microvilli and increased phosphorylation of ezrin (at Thr-567 and Tyr-353) [17].
  • Phosphorylation of ezrin on threonine T567 plays a crucial role during compaction in the mouse early embryo [18].
  • Alanine mutations of membrane-proximal basic amino acid residues in the cytoplasmic domain of L-selectin identified arginine 357 as a critical residue for both ezrin and moesin interaction [19].
  • Ezrin is a cyclic AMP-dependent protein kinase anchoring protein [20].

Physical interactions of Vil2

  • Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells [21].
  • Opossum kidney (OK) cells were transfected with either empty vector (control), full-length mouse (m) NHERF(1-355), or a truncated mNHERF(1-325) that lacked ezrin binding and had been demonstrated in fibroblasts to bind NHE3 but not mediate its cAMP-associated inhibition [21].

Enzymatic interactions of Vil2

  • Two isoforms of ezrin phosphorylated on tyrosine residues are present during all of preimplantation development while a third non-tyrosine-phosphorylated isoform appears at the 8-cell stage and its relative amount increases from the 8-cell stage to the blastocyst stage [22].

Co-localisations of Vil2

  • Phosphorylated ezrin-positive dots were colocalized with actin-positive dots on the surface of some Raf-1 transfectants treated with SB203580 [17].

Regulatory relationships of Vil2


Other interactions of Vil2


Analytical, diagnostic and therapeutic context of Vil2

  • Based on Western and immunoprecipitation data for ezrin, moesin, and PDZ-dc1 we believe that it is unlikely that our phosphoprotein is any of these 3 proteins [11].
  • Similar changes were seen following microinjection of anti-p81/ezrin antibody, suggesting that N-ezrin may function as a dominant negative competitor of ezrin [26].
  • Gel filtration and chemical cross-linking studies demonstrated that ezrin exists mainly in the form of noncovalent dimers and higher order oligomers in extracts of placental microvilli [27].
  • Gene array experiments, together with protein expression analysis by immunoblotting, revealed a differential spatiotemporal distribution of several proteins associated with epithelial maturation and polarization, including intercellular junctional proteins (e.g., ZO-1, claudin-3, E-cadherin) and the subapical cytoskeletal/microvillar protein ezrin [28].
  • VECs were identified by location, morphology, ezrin staining, and electron microscopy [29].


  1. Achlorhydria by ezrin knockdown: defects in the formation/expansion of apical canaliculi in gastric parietal cells. Tamura, A., Kikuchi, S., Hata, M., Katsuno, T., Matsui, T., Hayashi, H., Suzuki, Y., Noda, T., Tsukita, S., Tsukita, S. J. Cell Biol. (2005) [Pubmed]
  2. The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Khanna, C., Wan, X., Bose, S., Cassaday, R., Olomu, O., Mendoza, A., Yeung, C., Gorlick, R., Hewitt, S.M., Helman, L.J. Nat. Med. (2004) [Pubmed]
  3. Ezrin distribution is abnormal in principal cells from a murine model of autosomal recessive polycystic kidney disease. Orellana, S.A., Quinoñes, A.M., Mandapat, M.L. Pediatr. Res. (2003) [Pubmed]
  4. The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells. Elliott, B.E., Meens, J.A., SenGupta, S.K., Louvard, D., Arpin, M. Breast Cancer Res. (2005) [Pubmed]
  5. ICAM-2 redistributed by ezrin as a target for killer cells. Helander, T.S., Carpén, O., Turunen, O., Kovanen, P.E., Vaheri, A., Timonen, T. Nature (1996) [Pubmed]
  6. Assembly of focal adhesions: progress, paradigms, and portents. Craig, S.W., Johnson, R.P. Curr. Opin. Cell Biol. (1996) [Pubmed]
  7. The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A. Kishore, R., Qin, G., Luedemann, C., Bord, E., Hanley, A., Silver, M., Gavin, M., Yoon, Y.S., Goukassian, D., Goukassain, D., Losordo, D.W. J. Clin. Invest. (2005) [Pubmed]
  8. Association of ezrin isoforms with the neuronal cytoskeleton. Birgbauer, E., Dinsmore, J.H., Winckler, B., Lander, A.D., Solomon, F. J. Neurosci. Res. (1991) [Pubmed]
  9. Ezrin is a target for oncogenic Kit mutants in murine erythroleukemia. Monni, R., Haddaoui, L., Naba, A., Gallais, I., Arpin, M., Mayeux, P., Moreau-Gachelin, F. Blood (2008) [Pubmed]
  10. Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. Gomperts, B.N., Gong-Cooper, X., Hackett, B.P. J. Cell. Sci. (2004) [Pubmed]
  11. Molecular effects of volume expansion on the renal sodium phosphate cotransporter. Puschett, J.B., Whitbred, J., Ianosi-Irimie, M., Vu, H.V., Rabon, E., Robinson, J., Deininger, P. Am. J. Med. Sci. (2003) [Pubmed]
  12. Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout. Doi, Y., Itoh, M., Yonemura, S., Ishihara, S., Takano, H., Noda, T., Tsukita, S. J. Biol. Chem. (1999) [Pubmed]
  13. The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation. Fazioli, F., Wong, W.T., Ullrich, S.J., Sakaguchi, K., Appella, E., Di Fiore, P.P. Oncogene (1993) [Pubmed]
  14. Foxj1 is required for apical localization of ezrin in airway epithelial cells. Huang, T., You, Y., Spoor, M.S., Richer, E.J., Kudva, V.V., Paige, R.C., Seiler, M.P., Liebler, J.M., Zabner, J., Plopper, C.G., Brody, S.L. J. Cell. Sci. (2003) [Pubmed]
  15. Microvilli defects in retinas of ezrin knockout mice. Bonilha, V.L., Rayborn, M.E., Saotome, I., McClatchey, A.I., Hollyfield, J.G. Exp. Eye Res. (2006) [Pubmed]
  16. Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous system. Grönholm, M., Teesalu, T., Tyynelä, J., Piltti, K., Böhling, T., Wartiovaara, K., Vaheri, A., Carpén, O. Mol. Cell. Neurosci. (2005) [Pubmed]
  17. Phosphorylation of ezrin enhances microvillus length via a p38 MAP-kinase pathway in an immortalized mouse hepatic cell line. Lan, M., Kojima, T., Murata, M., Osanai, M., Takano, K., Chiba, H., Sawada, N. Exp. Cell Res. (2006) [Pubmed]
  18. Phosphorylation of ezrin on threonine T567 plays a crucial role during compaction in the mouse early embryo. Dard, N., Louvet-Vallée, S., Santa-Maria, A., Maro, B. Dev. Biol. (2004) [Pubmed]
  19. The cytoplasmic tail of L-selectin interacts with members of the Ezrin-Radixin-Moesin (ERM) family of proteins: cell activation-dependent binding of Moesin but not Ezrin. Ivetic, A., Deka, J., Ridley, A., Ager, A. J. Biol. Chem. (2002) [Pubmed]
  20. Ezrin is a cyclic AMP-dependent protein kinase anchoring protein. Dransfield, D.T., Bradford, A.J., Smith, J., Martin, M., Roy, C., Mangeat, P.H., Goldenring, J.R. EMBO J. (1997) [Pubmed]
  21. Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells. Weinman, E.J., Steplock, D., Wade, J.B., Shenolikar, S. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  22. Ezrin becomes restricted to outer cells following asymmetrical division in the preimplantation mouse embryo. Louvet, S., Aghion, J., Santa-Maria, A., Mangeat, P., Maro, B. Dev. Biol. (1996) [Pubmed]
  23. Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton. Lauritzen, I., Chemin, J., Honoré, E., Jodar, M., Guy, N., Lazdunski, M., Jane Patel, A. EMBO Rep. (2005) [Pubmed]
  24. Radixin is a novel member of the band 4.1 family. Funayama, N., Nagafuchi, A., Sato, N., Tsukita, S., Tsukita, S. J. Cell Biol. (1991) [Pubmed]
  25. Identification of PA2.26 antigen as a novel cell-surface mucin-type glycoprotein that induces plasma membrane extensions and increased motility in keratinocytes. Scholl, F.G., Gamallo, C., Vilar¿o, S., Quintanilla, M. J. Cell. Sci. (1999) [Pubmed]
  26. Identification of a 55-kDa ezrin-related protein that induces cytoskeletal changes and localizes to the nucleolus. Kaul, S.C., Kawai, R., Nomura, H., Mitsui, Y., Reddel, R.R., Wadhwa, R. Exp. Cell Res. (1999) [Pubmed]
  27. Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis. Berryman, M., Gary, R., Bretscher, A. J. Cell Biol. (1995) [Pubmed]
  28. Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney. Meyer, T.N., Schwesinger, C., Bush, K.T., Stuart, R.O., Rose, D.W., Shah, M.M., Vaughn, D.A., Steer, D.L., Nigam, S.K. Dev. Biol. (2004) [Pubmed]
  29. The cyclin kinase inhibitor p21CIP1/WAF1 limits glomerular epithelial cell proliferation in experimental glomerulonephritis. Kim, Y.G., Alpers, C.E., Brugarolas, J., Johnson, R.J., Couser, W.G., Shankland, S.J. Kidney Int. (1999) [Pubmed]
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