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Gene Review

Kmo  -  kynurenine 3-monooxygenase (kynurenine 3...

Rattus norvegicus

Synonyms: Kynurenine 3-hydroxylase, Kynurenine 3-monooxygenase
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Disease relevance of Kmo

  • Kynurenine 3-hydroxylase in brain: species activity differences and effect of gerbil cerebral ischemia [1].
  • Delayed increases in the activity of kynurenine 3-hydroxylase occur in several brain regions following transient ischemia in gerbils [1].

High impact information on Kmo


Biological context of Kmo


Anatomical context of Kmo


Associations of Kmo with chemical compounds


Other interactions of Kmo


Analytical, diagnostic and therapeutic context of Kmo


  1. Kynurenine 3-hydroxylase in brain: species activity differences and effect of gerbil cerebral ischemia. Saito, K., Quearry, B.J., Saito, M., Nowak, T.S., Markey, S.P., Heyes, M.P. Arch. Biochem. Biophys. (1993) [Pubmed]
  2. Kynurenine 3-hydroxylase inhibition in rats: effects on extracellular kynurenic acid concentration and N-methyl-D-aspartate-induced depolarisation in the striatum. Urenjak, J., Obrenovitch, T.P. J. Neurochem. (2000) [Pubmed]
  3. Synthesis and SAR of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids and esters and 2-amino-4-aryl-4-oxobut-2-enoic acids and esters: potent inhibitors of kynurenine-3-hydroxylase as potential neuroprotective agents. Drysdale, M.J., Hind, S.L., Jansen, M., Reinhard, J.F. J. Med. Chem. (2000) [Pubmed]
  4. Metabolism of [5-3H]kynurenine in the rat brain in vivo: evidence for the existence of a functional kynurenine pathway. Guidetti, P., Eastman, C.L., Schwarcz, R. J. Neurochem. (1995) [Pubmed]
  5. A radiometric assay for kynurenine 3-hydroxylase based on the release of 3H2O during hydroxylation of L-[3,5-3H]kynurenine. Erickson, J.B., Flanagan, E.M., Russo, S., Reinhard, J.F. Anal. Biochem. (1992) [Pubmed]
  6. Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. Röver, S., Cesura, A.M., Huguenin, P., Kettler, R., Szente, A. J. Med. Chem. (1997) [Pubmed]
  7. Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase. Pellicciari, R., Natalini, B., Costantino, G., Mahmoud, M.R., Mattoli, L., Sadeghpour, B.M., Moroni, F., Chiarugi, A., Carpenedo, R. J. Med. Chem. (1994) [Pubmed]
  8. (R,S)-3,4-dichlorobenzoylalanine (FCE 28833A) causes a large and persistent increase in brain kynurenic acid levels in rats. Speciale, C., Wu, H.Q., Cini, M., Marconi, M., Varasi, M., Schwarcz, R. Eur. J. Pharmacol. (1996) [Pubmed]
  9. Presence of kynurenine hydroxylase in developing rat brain. Battie, C., Verity, M.A. J. Neurochem. (1981) [Pubmed]
  10. Early effects of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene on mitochondrial outer membrane enzyme activities of rat liver. Yoshida, T., Yamamoto, T., Matsuura, Y., Kuroiwa, Y. Jpn. J. Pharmacol. (1985) [Pubmed]
  11. Increased phasic activity of dopaminergic neurones in the rat ventral tegmental area following pharmacologically elevated levels of endogenous kynurenic acid. Erhardt, S., Engberg, G. Acta Physiol. Scand. (2002) [Pubmed]
  12. The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats. Comai, S., Costa, C.V., Ragazzi, E., Bertazzo, A., Allegri, G. Clin. Chim. Acta (2005) [Pubmed]
  13. Kynurenine 3-monooxygenase activity of rat brain mitochondria determined by high performance liquid chromatography with electrochemical detection. Uemura, T., Hirai, K. Adv. Exp. Med. Biol. (1991) [Pubmed]
  14. Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo. Wu, H.Q., Guidetti, P., Goodman, J.H., Varasi, M., Ceresoli-Borroni, G., Speciale, C., Scharfman, H.E., Schwarcz, R. Neuroscience (2000) [Pubmed]
  15. Excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine. Erhardt, S., Schwieler, L., Engberg, G. Synapse (2002) [Pubmed]
  16. Cortical spreading depression augments kynurenate levels and reduces malonate toxicity in the rat cortex. Kiss, C., Shepard, P.D., Bari, F., Schwarcz, R. Brain Res. (2004) [Pubmed]
  17. Tryptophan metabolism along the kynurenine pathway in rats. Allegri, G., Ragazzi, E., Bertazzo, A., Costa, C.V., Rocchi, R. Adv. Exp. Med. Biol. (2003) [Pubmed]
  18. In vivo assessment of kynurenate neuroprotective potency and quinolinate excitotoxicity. Obrenovitch, T.P., Urenjak, J. Amino Acids (2000) [Pubmed]
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