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Tdo2  -  tryptophan 2,3-dioxygenase

Rattus norvegicus

Synonyms: TDO, TO, TRPO, Tdo, Tryptamin 2,3-dioxygenase, ...
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  1. Functional level of rat liver tryptophan 2,3-dixoygenase messenger RNA during superinduction of enzyme with actinomycin D. Killewich, L., Schutz, G., Feigelson, P. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  2. Glucocorticoid receptors in Morris hepatomas and host liver and the correlation of biological activity with receptor levels. McPartland, R.P., Milholland, R.J., Morris, H.P., Rosen, F. Cancer Res. (1977) [Pubmed]
  3. Pretranslational control of tryptophan oxygenase levels in Morris hepatoma and host liver. Ramanarayanan-Murthy, L., Colman, P.D., Morris, H.P., Feigelson, P. Cancer Res. (1976) [Pubmed]
  4. Prevention by pyrazole of the effects of chronic ethanol administration on the redox states of the hepatic nicotinamide--adenine dinucleotide (phosphate) couples and on liver and brain tryptophan metabolism in the rat. Punjani, N.F., Badawy, A.A., Evans, M. Biochem. J. (1979) [Pubmed]
  5. Alterations in jejunal transport and (Na+-K+)-ATPase in an experimental model of hypoxia in rats. Lifshitz, F., Wapnir, R.A., Teichberg, S. Proc. Soc. Exp. Biol. Med. (1986) [Pubmed]
  6. Exon and intron variants in the human tryptophan 2,3-dioxygenase gene: potential association with Tourette syndrome, substance abuse and other disorders. Comings, D.E., Gade, R., Muhleman, D., Chiu, C., Wu, S., To, M., Spence, M., Dietz, G., Winn-Deen, E., Rosenthal, R.J., Lesieur, H.R., Rugle, L., Sverd, J., Ferry, L., Johnson, J.P., MacMurray, J.P. Pharmacogenetics (1996) [Pubmed]
  7. Enzyme activity in sleep and sleep deprivation. Deguchi, T., Sinha, A.K., Dement, W.C., Barchas, J.D. Pharmacol. Biochem. Behav. (1975) [Pubmed]
  8. Liver tryptophan pyrrolase activity and metabolism of brain 5-HT in rat. Hillier, J., Hillier, J.G., Redfern, P.H. Nature (1975) [Pubmed]
  9. Hepatic heme metabolism and cytochrome P450 in cirrhotic rat liver. Farrell, G.C., Zaluzny, L. Gastroenterology (1985) [Pubmed]
  10. Tissue-specific DNaseI hypersensitive sites in the 5'-flanking sequences of the tryptophan oxygenase and the tyrosine aminotransferase genes. Becker, P., Renkawitz, R., Schütz, G. EMBO J. (1984) [Pubmed]
  11. Isotope effects and alternative substrate reactivities for tryptophan 2,3-dioxygenase. Leeds, J.M., Brown, P.J., McGeehan, G.M., Brown, F.K., Wiseman, J.S. J. Biol. Chem. (1993) [Pubmed]
  12. Subchronic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and their reversibility in male Sprague-Dawley rats. Li, X., Rozman, K.K. Toxicology (1995) [Pubmed]
  13. The inhibition of stress induced increase of liver enzyme activity by progesterone occurs in rats of both sexes. Németh, S., Viskupic, E., Jezová, D. Endocrinol. Exp. (1988) [Pubmed]
  14. The effect of tryptophan on the phenobarbital-mediated induction of cytochrome P-450 in rat liver. The role of tryptophan 2,3-dioxygenase. Kaliman, P.A., Manandhar, S.P. Biomed. Sci. (1991) [Pubmed]
  15. Interaction of glucocorticoids in stimulation of liver tyrosine aminotransferase and tryptophan pyrrolase by estrogen in female rats. Németh, S., Viskupic, E., Jezová-Repceková, D. Endocrinol. Exp. (1984) [Pubmed]
  16. Regulation of heme oxygenase activity in rat liver during oxidative stress induced by cobalt chloride and mercury chloride. Kaliman, P.A., Nikitchenko, I.V., Sokol, O.A., Strel'chenko, E.V. Biochemistry Mosc. (2001) [Pubmed]
  17. Deduced primary structure of rat tryptophan-2,3-dioxygenase. Maezono, K., Tashiro, K., Nakamura, T. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  18. Nucleotide sequence of a fragment of the rat tryptophan oxygenase gene showing high affinity to glucocorticoid receptor in vitro. Merkulov, V.M., Merkulova, T.I. Biochim. Biophys. Acta (1992) [Pubmed]
  19. Nicotinamide prolongs survival of primary cultured hepatocytes without involving loss of hepatocyte-specific functions. Inoue, C., Yamamoto, H., Nakamura, T., Ichihara, A., Okamoto, H. J. Biol. Chem. (1989) [Pubmed]
  20. Multihormonal regulation of transcription of the tryptophan 2,3-dioxygenase gene in primary cultures of adult rat hepatocytes with special reference to the presence of a transcriptional protein mediating the action of glucocorticoids. Nakamura, T., Niimi, S., Nawa, K., Noda, C., Ichihara, A., Takagi, Y., Anai, M., Sakaki, Y. J. Biol. Chem. (1987) [Pubmed]
  21. Transcriptional regulation of the tryptophan oxygenase gene in rat liver by glucocorticoids. Danesch, U., Hashimoto, S., Renkawitz, R., Schütz, G. J. Biol. Chem. (1983) [Pubmed]
  22. Alteration in the inducibility by dexamethasone of the activity of tyrosine aminotransferase and tryptophan oxygenase in regenerating rat liver after partial hepatectomy. Okamoto, K., Isohashi, F., Tsukanaka, K., Horiuchi, M., Sakamoto, Y. Endocrinology (1983) [Pubmed]
  23. Tryptophan 2,3-dioxygenase in chick embryo hepatocytes: studies in ovo and in culture. Lincoln, B.C., Alvarado, A., Setty, N., Bonkovsky, H.L. Proc. Soc. Exp. Biol. Med. (1988) [Pubmed]
  24. Involvement of lysosomes in substrate stabilization of tryptophan-2,3-dioxygenase in rat liver. Sato, A., Endo, Y., Natori, Y. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  25. The effects of saccharin on the metabolism of dietary tryptophan to indole, a known cocarcinogen for the urinary bladder of the rat. Sims, J., Renwick, A.G. Toxicol. Appl. Pharmacol. (1983) [Pubmed]
  26. Tryptophan catabolism by tryptophan pyrrolase in rat liver. The effect of tryptophan loads and changes in tryptophan pyrrolase activity. Young, S.N., Sourkes, T.L. J. Biol. Chem. (1975) [Pubmed]
  27. Glucocorticoid control of the development of tryptophan oxygenase in the young rat. Roper, M.D., Franz, J.M. J. Biol. Chem. (1977) [Pubmed]
  28. alpha-Adrenergic regulation of enzymes of amino acid metabolism in primary cultures of adult rat hepatocytes. Noda, C., Nakamura, T., Ichihara, A. J. Biol. Chem. (1983) [Pubmed]
  29. Diabetes-induced metabolic alterations in heme synthesis and degradation and various heme-containing enzymes in female rats. Bitar, M., Weiner, M. Diabetes (1984) [Pubmed]
  30. Hormonal regulation of translatable mRNA of tryptophan 2,3-dioxygenase in primary cultures of adult rat hepatocytes. Niimi, S., Nakamura, T., Nawa, K., Ichihara, A. J. Biochem. (1983) [Pubmed]
  31. Tissue-specific gene expression of heme oxygenase-1 (HO-1) and non-specific delta-aminolevulinate synthase (ALAS-N) in a rat model of septic multiple organ dysfunction syndrome. Suzuki, T., Takahashi, T., Yamasaki, A., Fujiwara, T., Hirakawa, M., Akagi, R. Biochem. Pharmacol. (2000) [Pubmed]
  32. Maintenance of connexin 32 and 26 expression in primary cultured rat hepatocytes treated with 3-acetylpyridine. Higaki, N., Mitaka, T., Sato, F., Hirata, K., Mochizuki, Y. J. Gastroenterol. Hepatol. (2001) [Pubmed]
  33. Inhibition of delta-aminolevulinate dehydratase in trichloroethylene-exposed rats, and the effects on heme regulation. Fujita, H., Koizumi, A., Yamamoto, M., Kumai, M., Sadamoto, T., Ikeda, M. Biochim. Biophys. Acta (1984) [Pubmed]
  34. Insulin and glucagon as a new regulator system for tryptophan oxygenase activity demonstrated in primary cultured rat hepatocytes. Nakamura, T., Shinno, H., Ichihara, A. J. Biol. Chem. (1980) [Pubmed]
  35. Induction of hepatic tyrosine aminotransferase mRNA by protein synthesis inhibitors. Ernest, M.J., DeLap, L., Feigelson, P. J. Biol. Chem. (1978) [Pubmed]
  36. Effects of acute paroxetine administration on tryptophan metabolism and disposition in the rat. Badawy, A.A., Morgan, C.J. Br. J. Pharmacol. (1991) [Pubmed]
  37. Tryptophan metabolism in the isolated perfused liver of the rat: effects of tryptophan concentration, hydrocortisone and allopurinol on tryptophan pyrrolase activity and kynurenine formation. Green, A.R., Woods, H.F., Joseph, M.H. Br. J. Pharmacol. (1976) [Pubmed]
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