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Gene Review

KMO  -  kynurenine 3-monooxygenase (kynurenine 3...

Homo sapiens

Synonyms: Kynurenine 3-hydroxylase, Kynurenine 3-monooxygenase
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Disease relevance of KMO


High impact information on KMO


Biological context of KMO


Anatomical context of KMO


Associations of KMO with chemical compounds


Other interactions of KMO


Analytical, diagnostic and therapeutic context of KMO

  • A new miniature membrane oxygenator (Kuraray KMO, size, 0.3 m2, with a priming volume of 47 ml, compliance of less than 0.1 ml/100 mmHg, and pressure loss of 45 mmHg) with improved gas transfer and mechanical durability was developed and tested [19].
  • The effects of the novel kynurenine 3-hydroxylase inhibitor 3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide (Ro 61-8048) on severity of dystonia were examined in dt(sz) mutant hamsters, an animal model of paroxysmal dystonia, in which stress precipitates dystonic episodes [4].


  1. A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate. Heyes, M.P., Saito, K., Major, E.O., Milstien, S., Markey, S.P., Vickers, J.H. Brain (1993) [Pubmed]
  2. An allosteric drug, o,o'-bismyristoyl thiamine disulfide, suppresses HIV-1 replication through prevention of nuclear translocation of both HIV-1 Tat and NF-kappa B. Shoji, S., Furuishi, K., Ogata, A., Yamataka, K., Tachibana, K., Mukai, R., Uda, A., Harano, K., Matsushita, S., Misumi, S. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  3. Effect of kynurenine 3-hydroxylase inhibition on the dyskinetic and antiparkinsonian responses to levodopa in Parkinsonian monkeys. Samadi, P., Grégoire, L., Rassoulpour, A., Guidetti, P., Izzo, E., Schwarcz, R., Bédard, P.J. Mov. Disord. (2005) [Pubmed]
  4. The kynurenine 3-hydroxylase inhibitor Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia. Richter, A., Hamann, M. Eur. J. Pharmacol. (2003) [Pubmed]
  5. FcepsilonRI induces the tryptophan degradation pathway involved in regulating T cell responses. von Bubnoff, D., Matz, H., Frahnert, C., Rao, M.L., Hanau, D., de la Salle, H., Bieber, T. J. Immunol. (2002) [Pubmed]
  6. Kinetics of gene induction after FcepsilonRI ligation of atopic monocytes identified by suppression subtractive hybridization. Von Bubnoff, D., Matz, H., Cazenave, J.P., Hanau, D., Bieber, T., De La Salle, H. J. Immunol. (2002) [Pubmed]
  7. A mechanism for increased quinolinic acid formation following acute systemic immune stimulation. Saito, K., Crowley, J.S., Markey, S.P., Heyes, M.P. J. Biol. Chem. (1993) [Pubmed]
  8. Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury. Bellac, C.L., Coimbra, R.S., Christen, S., Leib, S.L. Neurobiol. Dis. (2006) [Pubmed]
  9. Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43. Halford, S., Freedman, M.S., Bellingham, J., Inglis, S.L., Poopalasundaram, S., Soni, B.G., Foster, R.G., Hunt, D.M. Genomics (2001) [Pubmed]
  10. Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase. Breton, J., Avanzi, N., Magagnin, S., Covini, N., Magistrelli, G., Cozzi, L., Isacchi, A. Eur. J. Biochem. (2000) [Pubmed]
  11. Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population. Aoyama, N., Takahashi, N., Saito, S., Maeno, N., Ishihara, R., Ji, X., Miura, H., Ikeda, M., Suzuki, T., Kitajima, T., Yamanouchi, Y., Kinoshita, Y., Yoshida, K., Iwata, N., Inada, T., Ozaki, N. Genes Brain Behav. (2006) [Pubmed]
  12. Cloning and characterization of the Tribolium castaneum eye-color genes encoding tryptophan oxygenase and kynurenine 3-monooxygenase. Lorenzen, M.D., Brown, S.J., Denell, R.E., Beeman, R.W. Genetics (2002) [Pubmed]
  13. Regulation of the kynurenine metabolic pathway by interferon-gamma in murine cloned macrophages and microglial cells. Alberati-Giani, D., Ricciardi-Castagnoli, P., Köhler, C., Cesura, A.M. J. Neurochem. (1996) [Pubmed]
  14. Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia. Saito, K., Nowak, T.S., Markey, S.P., Heyes, M.P. J. Neurochem. (1993) [Pubmed]
  15. Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation. Saito, K., Nowak, T.S., Suyama, K., Quearry, B.J., Saito, M., Crowley, J.S., Markey, S.P., Heyes, M.P. J. Neurochem. (1993) [Pubmed]
  16. Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types. Heyes, M.P., Chen, C.Y., Major, E.O., Saito, K. Biochem. J. (1997) [Pubmed]
  17. Different structural organization of the encephalopsin gene in man and mouse. Kasper, G., Taudien, S., Staub, E., Mennerich, D., Rieder, M., Hinzmann, B., Dahl, E., Schwidetzky, U., Rosenthal, A., Rump, A. Gene (2002) [Pubmed]
  18. Tryptophan metabolism along the kynurenine pathway in diet-induced and genetic hypercholesterolemic rabbits. Allegri, G., Ragazzi, E., Costa, C.V., Caparrotta, L., Biasiolo, M., Comai, S., Bertazzo, A. Clin. Chim. Acta (2004) [Pubmed]
  19. Miniature membrane oxygenator for use in neonatal ECMO. Katayama, M., Miyasaka, K., Hirose, I., Shimada, M., Mimura, R., Akasu, H. ASAIO transactions / American Society for Artificial Internal Organs. (1991) [Pubmed]
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