The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

REG1P  -  regenerating islet-derived 1 pseudogene

Homo sapiens

Synonyms: REGL, RS
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of REGL

  • The EQ-5D and RS results indicate that patients with heartburn assign their health states substantial disutility and that it is feasible to estimate regression equations to predict utilities from heartburn-specific variables [1].
  • METHODS: The prospective multi-center PREVENT study randomized patients implanted with ICDs capable of atrioventricular pacing, in order to compare-using a cross-over design with two 3-month treatment periods-the benefits of 'rate smoothing' (RS) as a 'pause-prevention algorithm' for the prevention of ventricular tachyarrhythmias [2].
  • They included the following topics: 1) A ratio interval rating scale (Low Back Pain Rating Scale (RS)) was introduced [3].
  • Using a computer interview, both rating scale (RS) and standard gamble (SG) preference scores were elicited from 52 patients with diabetes mellitus [4].
  • For different diseases mean RS scores ranged from 0.80 (asthma) to 0.69 (angina pectoris), mean EQ-5D index values ranged from 0.79 (asthma) to 0.66 (low back pain) [5].

Psychiatry related information on REGL

  • The purpose of this study is to compare the psychometric qualities of two instruments for assessing patients' utilities, the rating scale (RS) and the standard gamble (SG) [6].
  • In multivariable models, RS scores were significantly associated with sexual orientation, PCS scores, MCS scores, symptoms, and spirituality (adjusted R = 0.61); TTO with symptoms and spirituality (adjusted R = 0.23); and SG with infection type, PCS scores, and symptoms (adjusted R = 0.24) [7].
  • Vignettes depicting varying severity in SD decrements on the SF-12 mental health summary scale, with corresponding symptom severity profiles, were valued by a convenience sample of general practitioners (n = 42) using the rating scale (RS) and time trade-off methods [8].
  • Insulin responses showed the same ranking but satiety responses were the reverse, the fine flour meal giving the lowest satiety response [AUC: 231.4 +/- 31.6 rating scale (RS) units.120 min] and the whole grain meal the highest response (AUC: 318.4 +/- 29.3 RS units.120 min) [9].

High impact information on REGL

  • Utilities (as measured by the standard gamble [SG] and rating scale [RS] techniques) were obtained from 482 patients who participated in a 1-year randomized controlled trial that compared LEF, methotrexate, and placebo [10].
  • A REG-related sequence (REGL) is also located in 2p12 and expressed in the pancreas [11].
  • CONCLUSIONS: This study demonstrates that RS protein is expressed in the pinealocytes but not in interstitial glial cells [12].
  • Although all the quality of life instruments showed the same trend in favour of salmeterol, only the AQLQ and RS utilities showed significantly greater improvement on salmeterol than on salbutamol [13].
  • A regional assignment has been made by in situ hybridization to metaphase chromosomes using two different fluorescently labelled genomic probes corresponding to the REG gene and a related gene REGL [14].

Biological context of REGL

  • The EQ-5D self-classifier and a RS were included in the 1998 cross-sectional postal Stockholm County public health survey to a representative sample (n = 4950, 20-88 years), 63% response rate [5].

Anatomical context of REGL

  • Initially a dense amorphous material was demonstrated on the surfaces of RS, which was thought to be the result of an interaction between a factor in rat serum and the glycocalyx; this material was greatly reduced within 2 h of transformation [15].
  • BACKGROUND AND PURPOSE: The rating scale (RS), standard gamble (SG), and time trade-off (TTO) for people with traumatic spinal cord injuries (SCIs) have not been reported [16].

Associations of REGL with chemical compounds

  • Compared with untreated, perfused control kidneys, glomerular Tx formation was significantly increased in ATS and RS perfused kidneys [17].

Analytical, diagnostic and therapeutic context of REGL

  • In the linear regression models, the RS was significantly associated with neurological severity, employment, educational level, and self-care ability; the SG was associated with neurological severity and employment; and the TTO was associated only with neurological severity [16].
  • METHODS: Four hundred sixty-five elderly persons living in long-term care institutions in Taiwan were interviewed using Taiwan's abbreviated version of the World Health Organization Quality of Life (WHOQOL-BREF), rating scale (RS) and the Time-Trade-Off (TTO) utility measurement [18].
  • Compared to the Time Trade-off (TTO) and the Standard Gamble (SG), the Rating Scale (RS) correlated with the SF-36 Health Survey most highly [19].
  • We compared the outcome of resection and anastomosis (RA) with stoma formation (RS) [20].
  • Thirty-seven neonates had RA (NEC 22, IIP 14, 1 unknown), 28 RS (NEC 21, IIP 6, 1 unknown), and 3 laparotomy only [20].


  1. Health state utilities in gastroesophageal reflux disease patients with heartburn: a study in Germany and Sweden. Kartman, B., Gatz, G., Johannesson, M. Medical decision making : an international journal of the Society for Medical Decision Making. (2004) [Pubmed]
  2. Prevention of sustained ventricular tachyarrhythmias in patients with implantable cardioverter-defibrillators-the PREVENT study. Wietholt, D., Kuehlkamp, V., Meisel, E., Hoffmann, E., Stellbrink, C., Neuzner, J., Seidl, K., Szigat, P., Potratz, J. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. (2003) [Pubmed]
  3. Assessment and exercise in low back pain. With special reference to the management of pain and disability following first time lumbar disc surgery. Manniche, C. Danish medical bulletin. (1995) [Pubmed]
  4. Health state preference assessment in diabetic peripheral neuropathy. Sullivan, S.D., Lew, D.P., Devine, E.B., Hakim, Z., Reiber, G.E., Veenstra, D.L. PharmacoEconomics. (2002) [Pubmed]
  5. Swedish population health-related quality of life results using the EQ-5D. Burström, K., Johannesson, M., Diderichsen, F. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. (2001) [Pubmed]
  6. Patient utilities in chronic musculoskeletal pain: how useful is the standard gamble method? Goossens, M.E., Vlaeyen, J.W., Rutten-van Mölken, M.P., van der Linden, S.M. Pain (1999) [Pubmed]
  7. Health values of patients coinfected with HIV/hepatitis C: are two viruses worse than one? Mrus, J.M., Sherman, K.E., Leonard, A.C., Sherman, S.N., Mandell, K.L., Tsevat, J. Medical care. (2006) [Pubmed]
  8. Using the effect size to model change in preference values from descriptive health status. Sanderson, K., Andrews, G., Corry, J., Lapsley, H. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. (2004) [Pubmed]
  9. Particle size, satiety and the glycaemic response. Holt, S.H., Miller, J.B. European journal of clinical nutrition. (1994) [Pubmed]
  10. Cost effectiveness of adding leflunomide to a 5-year strategy of conventional disease-modifying antirheumatic drugs in patients with rheumatoid arthritis. Maetzel, A., Strand, V., Tugwell, P., Wells, G., Bombardier, C. Arthritis Rheum. (2002) [Pubmed]
  11. A limited genomic region contains the human REG and REG-related genes. Bartoli, C., Dagorn, J.C., Fontes, M., Bergé-Lefranc, J.L. Eur. J. Hum. Genet. (1995) [Pubmed]
  12. Retinoschisin expression and localization in rodent and human pineal and consequences of mouse RS1 gene knockout. Takada, Y., Fariss, R.N., Muller, M., Bush, R.A., Rushing, E.J., Sieving, P.A. Mol. Vis. (2006) [Pubmed]
  13. Comparison of performance of four instruments in evaluating the effects of salmeterol on asthma quality of life. Rutten-van Mölken, M.P., Custers, F., van Doorslaer, E.K., Jansen, C.C., Heurman, L., Maesen, F.P., Smeets, J.J., Bommer, A.M., Raaijmakers, J.A. Eur. Respir. J. (1995) [Pubmed]
  14. Human regeneration protein/lithostathine genes map to chromosome 2p12. Gharib, B., Fox, M.F., Bartoli, C., Giorgi, D., Sansonetti, A., Swallow, D.M., Dagorn, J.C., Berge-lefranc, J.L. Ann. Hum. Genet. (1993) [Pubmed]
  15. Schistosoma mansoni: a comparative study of artificially transformed schistosomula and schistosomula recovered after cercarial penetration of isolated skin. Brink, L.H., McLaren, D.J., Smithers, S.R. Parasitology (1977) [Pubmed]
  16. Rating scale, standard gamble, and time trade-off for people with traumatic spinal cord injuries. Lin, M.R., Hwang, H.F., Chung, K.P., Huang, C., Chen, C.Y. Physical therapy. (2006) [Pubmed]
  17. Antibody and complement reduce renal hemodynamic function in isolated perfused rat kidney. Jocks, T., Zahner, G., Helmchen, U., Kneissler, U., Stahl, R.A. Am. J. Physiol. (1996) [Pubmed]
  18. Health-related quality of life and health utility for the institutional elderly in Taiwan. Lai, K.L., Tzeng, R.J., Wang, B.L., Lee, H.S., Amidon, R.L., Kao, S. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. (2005) [Pubmed]
  19. Comparing the psychometric properties of preference-based and nonpreference-based health-related quality of life in coronary heart disease. Canadian Collaborative Cardiac Assessment Group. Lalonde, L., Clarke, A.E., Joseph, L., Mackenzie, T., Grover, S.A. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. (1999) [Pubmed]
  20. Surgery for intestinal perforation in preterm neonates: anastomosis vs stoma. Singh, M., Owen, A., Gull, S., Morabito, A., Bianchi, A. J. Pediatr. Surg. (2006) [Pubmed]
WikiGenes - Universities