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Gene Review

LOC606743  -  A1 adenosine receptor

Sus scrofa

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Disease relevance of LOC606743


High impact information on LOC606743


Chemical compound and disease context of LOC606743


Biological context of LOC606743


Anatomical context of LOC606743


Associations of LOC606743 with chemical compounds


Regulatory relationships of LOC606743


Analytical, diagnostic and therapeutic context of LOC606743

  • Evaluation of radioiodinated 8-Cyclopentyl-3-[(E)-3-iodoprop-2-en-1-yl]-1-propylxanthine ([*I]CPIPX) as a new potential A1 adenosine receptor antagonist for SPECT [24].


  1. Selective A2-adenosine receptor agonists do not alter action potential duration, twitch shortening, or cAMP accumulation in guinea pig, rat, or rabbit isolated ventricular myocytes. Shryock, J., Song, Y., Wang, D., Baker, S.P., Olsson, R.A., Belardinelli, L. Circ. Res. (1993) [Pubmed]
  2. Endogenous adenosine, A1 adenosine receptor, and pertussis toxin sensitive guanine nucleotide binding protein mediate hypoxia induced AV nodal conduction block in guinea pig heart in vivo. Xu, J., Tong, H., Wang, L., Hurt, C.M., Pelleg, A. Cardiovasc. Res. (1993) [Pubmed]
  3. Effects of R-PIA, a selective A1 adenosine agonist, on haemodynamics and ischaemic arrhythmias in pigs. Wainwright, C.L., Parratt, J.R. Cardiovasc. Res. (1993) [Pubmed]
  4. In vitro and in vivo pharmacological characterization of N6-cyclopentyl-9-methyladenine (N-0840): a selective, orally active A1 adenosine receptor antagonist. Barrett, R.J., May, J.M., Martin, P.L., Miller, J.R. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  5. Effect of A1 adenosine receptor agonist upon cochlear dysfunction induced by transient ischemia. Tabuchi, K., Ito, Z., Wada, T., Takahashi, K., Hara, A., Kusakari, J. Hear. Res. (1999) [Pubmed]
  6. Modulation of atrioventricular nodal function by metabolic and allosteric regulators of endogenous adenosine in guinea pig heart. Dennis, D.M., Raatikainen, M.J., Martens, J.R., Belardinelli, L. Circulation (1996) [Pubmed]
  7. Endogenous adenosine does not activate ATP-sensitive potassium channels in the hypoxic guinea pig ventricle in vivo. Xu, J., Wang, L., Hurt, C.M., Pelleg, A. Circulation (1994) [Pubmed]
  8. [3H]xanthine amine congener of 1,3-dipropyl-8-phenylxanthine: an antagonist radioligand for adenosine receptors. Jacobson, K.A., Ukena, D., Kirk, K.L., Daly, J.W. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  9. Binding of A1 adenosine receptor ligand [3H]8-cyclopentyl-1,3-dipropylxanthine in coronary smooth muscle. Hussain, T., Mustafa, S.J. Circ. Res. (1995) [Pubmed]
  10. A1-adenosine receptor-mediated inhibition of isoproterenol-stimulated protein phosphorylation in ventricular myocytes. Evidence against a cAMP-dependent effect. Gupta, R.C., Neumann, J., Durant, P., Watanabe, A.M. Circ. Res. (1993) [Pubmed]
  11. Pharmacological characterization of the adenylate cyclase-coupled adenosine receptor in isolated guinea pig atrial myocytes. Wilken, A., Tawfik-Schlieper, H., Klotz, K.N., Schwabe, U. Mol. Pharmacol. (1990) [Pubmed]
  12. Role of histidine residues in agonist and antagonist binding sites of A1 adenosine receptor. Allende, G., Casadó, V., Mallol, J., Franco, R., Lluis, C., Canela, E.I. J. Neurochem. (1993) [Pubmed]
  13. Differential antagonism of cardiac actions of adenosine by theophylline. Bertolet, B.D., Belardinelli, L., Avasarala, K., Calhoun, W.B., Franco, E.A., Nichols, W.W., Kerensky, R.A., Hill, J.A. Cardiovasc. Res. (1996) [Pubmed]
  14. Selective potentiation by an A1 adenosine receptor enhancer of the negative dromotropic action of adenosine in the guinea pig heart. Amoah-Apraku, B., Xu, J., Lu, J.Y., Pelleg, A., Bruns, R.F., Belardinelli, L. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  15. Cloning and characterization of a pharmacologically distinct A1 adenosine receptor from guinea pig brain. Meng, F., Xie, G.X., Chalmers, D., Morgan, C., Watson, S.J., Akil, H. Brain Res. Mol. Brain Res. (1994) [Pubmed]
  16. A novel irreversible antagonist of the A1-adenosine receptor. Srinivas, M., Shryock, J.C., Scammells, P.J., Ruble, J., Baker, S.P., Belardinelli, L. Mol. Pharmacol. (1996) [Pubmed]
  17. Novel mitogenic effect of adenosine on coronary artery smooth muscle cells: role for the A1 adenosine receptor. Shen, J., Halenda, S.P., Sturek, M., Wilden, P.A. Circ. Res. (2005) [Pubmed]
  18. Enhanced sensitivity of heart cells to adenosine and up-regulation of receptor number after treatment of guinea pigs with theophylline. Wu, S.N., Linden, J., Visentin, S., Boykin, M., Belardinelli, L. Circ. Res. (1989) [Pubmed]
  19. Adenosine receptors in myelin fractions and subfractions: the effect of the agonist (R)-phenylisopropyladenosine on myelin membrane microviscosity. Casadó, V., Mallol, J., Lluis, C., Franco, R., Canela, E.I. J. Neurochem. (1991) [Pubmed]
  20. Adenosine-sensitive afterdepolarizations and triggered activity in guinea pig ventricular myocytes. Song, Y., Thedford, S., Lerman, B.B., Belardinelli, L. Circ. Res. (1992) [Pubmed]
  21. Persistent activation by and receptor reserve for an irreversible A1-adenosine receptor agonist in DDT1 MF-2 cells and in guinea pig heart. Zhang, J., Belardinelli, L., Jacobson, K.A., Otero, D.H., Baker, S.P. Mol. Pharmacol. (1997) [Pubmed]
  22. Selective attenuation by adenosine of arrhythmogenic action of isoproterenol on ventricular myocytes. Song, Y., Shryock, J.C., Knot, H.J., Belardinelli, L. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  23. Protein kinase C isoforms and A1 adenosine receptors in porcine coronary smooth muscle cells. Nayeem, M.A., Mustafa, S.J. Vascul. Pharmacol. (2002) [Pubmed]
  24. Evaluation of radioiodinated 8-Cyclopentyl-3-[(E)-3-iodoprop-2-en-1-yl]-1-propylxanthine ([*I]CPIPX) as a new potential A1 adenosine receptor antagonist for SPECT. Sihver, W., Holschbach, M.H., Bier, D., Wutz, W., Schulze, A., Olsson, R.A., Coenen, H.H. Nucl. Med. Biol. (2003) [Pubmed]
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