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Gene Review

RPL5  -  ribosomal protein L5

Homo sapiens

Synonyms: 60S ribosomal protein L5, DBA6, L5, MSTP030, PPP1R135
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Disease relevance of RPL5


High impact information on RPL5


Biological context of RPL5


Anatomical context of RPL5


Associations of RPL5 with chemical compounds


Other interactions of RPL5

  • Interaction of the beta subunit of casein kinase II with the ribosomal protein L5 [11].
  • To better understand the strategies developed by higher plants to transfer organellar genes during evolution, we investigated the fate of the mitochondrial RPL5-RPS14 locus in grasses [9].
  • This nuclear wheat RPL5 acquired its targeting information by duplication of an existing targeting presequence for another mitochondrial protein, ribosomal protein L4 [9].

Analytical, diagnostic and therapeutic context of RPL5


  1. Interaction of the HIV-1 rev cofactor eukaryotic initiation factor 5A with ribosomal protein L5. Schatz, O., Oft, M., Dascher, C., Schebesta, M., Rosorius, O., Jaksche, H., Dobrovnik, M., Bevec, D., Hauber, J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Ribosomal protein L5 has a highly twisted concave surface and flexible arms responsible for rRNA binding. Nakashima, T., Yao, M., Kawamura, S., Iwasaki, K., Kimura, M., Tanaka, I. RNA (2001) [Pubmed]
  3. A 5S rRNA/L5 complex is a precursor to ribosome assembly in mammalian cells. Steitz, J.A., Berg, C., Hendrick, J.P., La Branche-Chabot, H., Metspalu, A., Rinke, J., Yario, T. J. Cell Biol. (1988) [Pubmed]
  4. Nucleophosmin is essential for ribosomal protein L5 nuclear export. Yu, Y., Maggi, L.B., Brady, S.N., Apicelli, A.J., Dai, M.S., Lu, H., Weber, J.D. Mol. Cell. Biol. (2006) [Pubmed]
  5. Human ribosomal protein L5 contains defined nuclear localization and export signals. Rosorius, O., Fries, B., Stauber, R.H., Hirschmann, N., Bevec, D., Hauber, J. J. Biol. Chem. (2000) [Pubmed]
  6. Cytosolic import factor- and Ran-independent nuclear transport of ribosomal protein L5. Rudt, F., Pieler, T. Eur. J. Cell Biol. (2001) [Pubmed]
  7. Phosphorylation of ribosomal protein L5 by protein kinase CKII decreases its 5S rRNA binding activity. Park, J.W., Bae, Y.S. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  8. Ribosomal protein gene rpl5 is cotranscribed with the nad3 gene in Oenothera mitochondria. Schuster, W. Mol. Gen. Genet. (1993) [Pubmed]
  9. Transfer of RPS14 and RPL5 from the mitochondrion to the nucleus in grasses. Sandoval, P., León, G., Gómez, I., Carmona, R., Figueroa, P., Holuigue, L., Araya, A., Jordana, X. Gene (2004) [Pubmed]
  10. Overexpression of ribosomal proteins L4 and L5 and the putative alternative elongation factor PTI-1 in the doxorubicin resistant human colon cancer cell line LoVoDxR. Bertram, J., Palfner, K., Hiddemann, W., Kneba, M. Eur. J. Cancer (1998) [Pubmed]
  11. Interaction of the beta subunit of casein kinase II with the ribosomal protein L5. Kim, J.M., Cha, J.Y., Marshak, D.R., Bae, Y.S. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  12. Presence of role of the 5SrRNA-L5 protein complex (5SRNP) in the threonyl- and histidyl-tRNA synthetase complex in rat liver cytosol. Ogata, K., Kurahashi, A., Nishiyama, C., Terao, K. Biochim. Biophys. Acta (1994) [Pubmed]
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