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Gene Review

RPS3  -  ribosomal protein S3

Homo sapiens

Synonyms: 40S ribosomal protein S3, FLJ26283, FLJ27450, MGC87870, OK/SW-cl.26, ...
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Disease relevance of RPS3


High impact information on RPS3


Biological context of RPS3


Anatomical context of RPS3

  • These results together indicated that all four genes, namely, rps3, rpl16, nad3 and rps12, were co-transcribed in rice mitochondria [13].
  • Immunohistochemical analysis revealed that PEP-1-rpS3 fusion protein efficiently penetrated the epidermis as well as the dermis of the subcutaneous layer when sprayed on animal skin [14].
  • Using the anti-rpS3 antibodies as probes, we investigated the cross-reactivities of various other mammalian brain tissues and cell lines, including human [4].
  • Among the various regions in the brain tissues, the rpS3 positive neurons were predominantly observed in the ependymal cells, hippocampus and stantia nigra pars compacta [4].

Associations of RPS3 with chemical compounds

  • Erk phosphorylates threonine 42 residue of ribosomal protein S3 [15].
  • This sequence contains putative genes that encode initiator methionine tRNA (trnfM), subunits III (nad3) and IV (nad4) of the NADH dehydrogenase complex, and ribosomal proteins S3 (rps3), S12 (rps12) and L16 (rpl16) [16].

Other interactions of RPS3

  • Moreover, the first intron of human RPS3 transcripts is processed to generate U15A, a small nucleolar RNA [9].
  • Complete genomic structure of human rpS3: identification of functional U15b snoRNA in the fifth intron [11].
  • During evolution the maize mitochondrial ribosomal protein subunit 12 (rps12) gene recombined with intron 1 of the ribosomal protein subunit 3 (rps3) gene and a region of the S1-like sequence of the 2.3 kb plasmid [17].
  • The genes of the prokaryotic-like cistron that includes the rpsl9, rps3, rpl16, rpl5, and rpsl4 genes, which is at least partially conserved in the mitochondrial genomes of other higher and lower plants, are dispersed in the Oenothera mitochondrial genome [18].
  • Reduction of invasion in human fibrosarcoma cells by ribosomal protein S3 in conjunction with Nm23-H1 and ERK [19].

Analytical, diagnostic and therapeutic context of RPS3

  • A gene for a ribosomal protein, rps3, was amplified by PCR and sequenced from representatives of the class Mollicutes [2].
  • In addition, sequence analysis of the clones also suggests that ribosomal protein S3 and cytochrome b as well as additional 4 uncharacterized genes may potentially be involved in P. aeruginosa pathogenesis [20].
  • DNA analysis and Western blot analysis did not show significant differences in ribosomal protein S3 between FA cells and cells from healthy individuals [3].
  • The binding affinity of mAbs to rpS3 determined by using a biosensor technology showed that they have similar binding affinities [4].
  • Furthermore, these antibodies were successfully applied in immunohistochemistry in order to detect rpS3 in the gerbil brain tissues [4].


  1. Solution structure and function of a conserved protein SP14.3 encoded by an essential Streptococcus pneumoniae gene. Yu, L., Gunasekera, A.H., Mack, J., Olejniczak, E.T., Chovan, L.E., Ruan, X., Towne, D.L., Lerner, C.G., Fesik, S.W. J. Mol. Biol. (2001) [Pubmed]
  2. Phylogenetic relationships among members of the class Mollicutes deduced from rps3 gene sequences. Toth, K.F., Harrison, N., Sears, B.B. Int. J. Syst. Bacteriol. (1994) [Pubmed]
  3. Chromosomal instability of fanconi anemia cells is not the consequence of a defective repair activity of the ribosomal protein S3. Ramirez, M.H., Ruppitsch, W., Hirsch-Kauffmann, M., Schweiger, M. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  4. Immunohistochemical studies of human ribosomal protein S3 (rpS3). Choi, S.H., Kim, S.Y., An, J.J., Lee, S.H., Kim, D.W., Won, M.H., Kang, T.C., Park, J., Eum, W.S., Kim, J., Choi, S.Y. J. Biochem. Mol. Biol. (2006) [Pubmed]
  5. A small nucleolar RNA is processed from an intron of the human gene encoding ribosomal protein S3. Tycowski, K.T., Shu, M.D., Steitz, J.A. Genes Dev. (1993) [Pubmed]
  6. Fugu intron oversize reveals the presence of U15 snoRNA coding sequences in some introns of the ribosomal protein S3 gene. Crosio, C., Cecconi, F., Mariottini, P., Cesareni, G., Brenner, S., Amaldi, F. Genome Res. (1996) [Pubmed]
  7. Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradation. Kim, T.S., Jang, C.Y., Kim, H.D., Lee, J.Y., Ahn, B.Y., Kim, J. Mol. Biol. Cell (2006) [Pubmed]
  8. Implication of mammalian ribosomal protein S3 in the processing of DNA damage. Kim, J., Chubatsu, L.S., Admon, A., Stahl, J., Fellous, R., Linn, S. J. Biol. Chem. (1995) [Pubmed]
  9. Mapping of ribosomal protein S3 and internally nested snoRNA U15A gene to human chromosome 11q13.3-q13.5. Polakiewicz, R.D., Munroe, D.J., Sait, S.N., Tycowski, K.T., Nowak, N.J., Shows, T.B., Housman, D.E., Page, D.C. Genomics (1995) [Pubmed]
  10. Human ribosomal protein S3 interacts with DNA base excision repair proteins hAPE/Ref-1 and hOGG1. Hegde, V., Wang, M., Deutsch, W.A. Biochemistry (2004) [Pubmed]
  11. Complete genomic structure of human rpS3: identification of functional U15b snoRNA in the fifth intron. Lim, Y., Lee, S.M., Kim, M., Lee, J.Y., Moon, E.P., Lee, B.J., Kim, J. Gene (2002) [Pubmed]
  12. Isolation of ethanol-induced genes in pancreatic beta-cells by representational difference analysis (RDA). Shin, J.S., Kwon, Y.S., Lee, J.J., Kim, C.W. Exp. Mol. Med. (2004) [Pubmed]
  13. The rps3-rpl16-nad3-rps12 gene cluster in rice mitochondrial DNA is transcribed from alternative promoters. Nakazono, M., Itadani, H., Wakasugi, T., Tsutsumi, N., Sugiura, M., Hirai, A. Curr. Genet. (1995) [Pubmed]
  14. Human PEP-1-ribosomal protein S3 protects against UV-induced skin cell death. Choi, S.H., Kim, S.Y., An, J.J., Lee, S.H., Kim, D.W., Ryu, H.J., Lee, N.I., Yeo, S.I., Jang, S.H., Won, M.H., Kang, T.C., Kwon, H.J., Cho, S.W., Kim, J., Lee, K.S., Park, J., Eum, W.S., Choi, S.Y. FEBS Lett. (2006) [Pubmed]
  15. Erk phosphorylates threonine 42 residue of ribosomal protein S3. Kim, H.D., Lee, J.Y., Kim, J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  16. Nucleotide sequence of a 28-kbp portion of rice mitochondrial DNA: the existence of many sequences that correspond to parts of mitochondrial genes in intergenic regions. Itadani, H., Wakasugi, T., Sugita, M., Sugiura, M., Nakazono, M., Hirai, A. Plant Cell Physiol. (1994) [Pubmed]
  17. Editing site recognition in plant mitochondria: the importance of 5'-flanking sequences. Williams, M.A., Kutcher, B.M., Mulligan, R.M. Plant Mol. Biol. (1998) [Pubmed]
  18. Ribosomal protein gene rpl5 is cotranscribed with the nad3 gene in Oenothera mitochondria. Schuster, W. Mol. Gen. Genet. (1993) [Pubmed]
  19. Reduction of invasion in human fibrosarcoma cells by ribosomal protein S3 in conjunction with Nm23-H1 and ERK. Kim, S.H., Kim, J. Biochim. Biophys. Acta (2006) [Pubmed]
  20. Identification of Pseudomonas aeruginosa-induced genes in human mast cells using suppression subtractive hybridization: up-regulation of IL-8 and CCL4 production. Sun, G., Liu, F., Lin, T.J. Clin. Exp. Immunol. (2005) [Pubmed]
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