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Gene Review

RPS6KB2  -  ribosomal protein S6 kinase, 70kDa,...

Homo sapiens

Synonyms: 70 kDa ribosomal protein S6 kinase 2, KLS, P70-BETA, P70-beta, P70-beta-1, ...
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Disease relevance of RPS6KB2

  • Immunohistochemical analysis of S6K1 and S6K2 expression in endometrial adenocarcinomas [1].
  • FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2 [2].
  • Immunohistochemical analysis of S6K1 and S6K2 expression in human breast tumors [3].
  • To investigate the catalytic properties of the Brassica oleracea S-locus receptor kinase (SRK), we have expressed the domain that is homologous to protein kinases as a fusion protein in Escherichia coli [4].
  • In the prediction of ametropia, the SRK method showed a tendency to predict refractions that were lower than the actual values in hyperopic eyes and higher than the actual values in myopic eyes [5].

Psychiatry related information on RPS6KB2

  • No case in the standard SRK/T group and 6 cases (66.66%) in the double-K group achieved a +/-0.5 D SE [6].

High impact information on RPS6KB2

  • In a tetracycline-inducible system, increased S6K2 kinase activity triggers upregulation of XIAP, Bcl-X(L) and prosurvival effects [2].
  • RNAi-mediated downregulation of B-Raf, PKCepsilon or S6K2 abolishes FGF-2-mediated survival [2].
  • Thus, including SRK, the S locus in the S15 haplotype contains at least three members of the S gene family [7].
  • Phosphorylation was shown to occur in trans, suggesting the existence of constitutive homooligomers of membrane-anchored recombinant SRK [8].
  • To investigate the physiological relevance of these results, we have examined the oligomeric status of SRK in planta in cross-linking experiments and by velocity sedimentation on sucrose gradients [8].

Biological context of RPS6KB2


Anatomical context of RPS6KB2


Associations of RPS6KB2 with chemical compounds


Regulatory relationships of RPS6KB2

  • We have recently demonstrated that S6K2 is regulated similarly to S6K1 by the mammalian target of rapamycin pathway and by multiple PI3-K pathway effectors in vivo [15].
  • Pretreatment of cells with the mitogen-activated protein-extracellular signal-regulated kinase kinase (MEK) inhibitor U0126 inhibited S6K2 activation to a greater extent than S6K1 [15].
  • Similar to S6K1, S6K2 is activated by mitogens and by constitutively active PI3K, and is inhibited by rapamycin as well as wortmannin [17].

Other interactions of RPS6KB2

  • The C-terminal sequence of S6K2 is divergent from that of S6K1 [18].
  • Similarly to p70alpha, the catalytic activity of p70beta toward ribosomal protein S6 could be rapidly activated by serum, insulin, and phorbol ester in transiently transfected cells [9].
  • Two isoforms of p70beta, referred to as beta1 (495 amino acids) and beta2 (482 amino acids), could be expressed from the single gene either by alternative mRNA splicing or by the use of alternative start codons [9].
  • Thus, MEK-dependent inputs to C-terminal phosphorylation sites appear to be essential for relief of S6K2 inhibition but less critical for activation of S6K1 [15].
  • We demonstrate that the inhibitory effects of the S6K2 C-terminal domain are only partly attributable to the nuclear localization signal but that three C-terminal proline-directed potential mitogen-activated protein kinase phosphorylation sites are critical mediators of this inhibitory effect [15].

Analytical, diagnostic and therapeutic context of RPS6KB2


  1. Immunohistochemical analysis of S6K1 and S6K2 expression in endometrial adenocarcinomas. Lyzogubov, V.V., Lytvyn, D.I., Dudchenko, T.M., Lubchenko, N.V., Pogrybniy, P.V., Nespryadko, S.V., Vinnitska, A.B., Usenko, V.S., Gout, I.T., Filonenko, V.V. Experimental oncology. (2004) [Pubmed]
  2. FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2. Pardo, O.E., Wellbrock, C., Khanzada, U.K., Aubert, M., Arozarena, I., Davidson, S., Bowen, F., Parker, P.J., Filonenko, V.V., Gout, I.T., Sebire, N., Marais, R., Downward, J., Seckl, M.J. EMBO J. (2006) [Pubmed]
  3. Immunohistochemical analysis of S6K1 and S6K2 expression in human breast tumors. Savinska, L.O., Lyzogubov, V.V., Usenko, V.S., Ovcharenko, G.V., Gorbenko, O.N., Rodnin, M.V., Vudmaska, M.I., Pogribniy, P.V., Kyyamova, R.G., Panasyuk, G.G., Nemazanyy, I.O., Malets, M.S., Palchevskyy, S.S., Gout, I.T., Filonenko, V.V. Eksp. Onkol. (2004) [Pubmed]
  4. A plant receptor-like gene, the S-locus receptor kinase of Brassica oleracea L., encodes a functional serine/threonine kinase. Stein, J.C., Nasrallah, J.B. Plant Physiol. (1993) [Pubmed]
  5. Theoretical, computer-assisted prediction versus SRK prediction of postoperative refraction after intraocular lens implantation. Olsen, T. Journal of cataract and refractive surgery. (1987) [Pubmed]
  6. Intraocular lens power calculation after corneal refractive surgery: double-K method. Aramberri, J. Journal of cataract and refractive surgery. (2003) [Pubmed]
  7. The S15 self-incompatibility haplotype in Brassica oleracea includes three S gene family members expressed in stigmas. Cabrillac, D., Delorme, V., Garin, J., Ruffio-Châble, V., Giranton, J.L., Dumas, C., Gaude, T., Cock, J.M. Plant Cell (1999) [Pubmed]
  8. The integral membrane S-locus receptor kinase of Brassica has serine/threonine kinase activity in a membranous environment and spontaneously forms oligomers in planta. Giranton, J.L., Dumas, C., Cock, J.M., Gaude, T. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  9. Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. Gout, I., Minami, T., Hara, K., Tsujishita, Y., Filonenko, V., Waterfield, M.D., Yonezawa, K. J. Biol. Chem. (1998) [Pubmed]
  10. Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin. Park, I.H., Bachmann, R., Shirazi, H., Chen, J. J. Biol. Chem. (2002) [Pubmed]
  11. SKAR is a specific target of S6 kinase 1 in cell growth control. Richardson, C.J., Bröenstrup, M., Fingar, D.C., Jülich, K., Ballif, B.A., Gygi, S., Blenis, J. Curr. Biol. (2004) [Pubmed]
  12. Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells. Pardo, O.E., Arcaro, A., Salerno, G., Tetley, T.D., Valovka, T., Gout, I., Seckl, M.J. Oncogene (2001) [Pubmed]
  13. Clinical evaluation of the Holladay and SRK II formulas. Richards, S.C., Steen, D.W. Journal of cataract and refractive surgery. (1990) [Pubmed]
  14. Landau-Kleffner syndrome is not an eponymic badge of ignorance. Hirsch, E., Valenti, M.P., Rudolf, G., Seegmuller, C., de Saint Martin, A., Maquet, P., Wioland, N., Metz-Lutz, M.N., Marescaux, C., Arzimanoglou, A. Epilepsy Res. (2006) [Pubmed]
  15. Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation. Martin, K.A., Schalm, S.S., Romanelli, A., Keon, K.L., Blenis, J. J. Biol. Chem. (2001) [Pubmed]
  16. Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1. Phin, S., Kupferwasser, D., Lam, J., Lee-Fruman, K.K. Biochem. J. (2003) [Pubmed]
  17. Characterization of S6K2, a novel kinase homologous to S6K1. Lee-Fruman, K.K., Kuo, C.J., Lippincott, J., Terada, N., Blenis, J. Oncogene (1999) [Pubmed]
  18. Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway. Martin, K.A., Schalm, S.S., Richardson, C., Romanelli, A., Keon, K.L., Blenis, J. J. Biol. Chem. (2001) [Pubmed]
  19. Development of the SRK/T intraocular lens implant power calculation formula. Retzlaff, J.A., Sanders, D.R., Kraff, M.C. Journal of cataract and refractive surgery. (1990) [Pubmed]
  20. Effect of the Morcher capsular tension ring on refractive outcome. Boomer, J.A., Jackson, D.W. Journal of cataract and refractive surgery. (2006) [Pubmed]
  21. Sporophytic self-incompatibility in Senecio squalidus L (Asteraceae)--the search for S. Hiscock, S.J., McInnis, S.M., Tabah, D.A., Henderson, C.A., Brennan, A.C. J. Exp. Bot. (2003) [Pubmed]
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