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Gene Review

NRP2  -  neuropilin 2

Homo sapiens

Synonyms: NP2, NPN2, Neuropilin-2, PRO2714, VEGF165R2, ...
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Disease relevance of NRP2


High impact information on NRP2


Biological context of NRP2


Anatomical context of NRP2

  • Moreover, a siRNA targeting specifically NRP2 was a potent inhibitor of human endothelial cell migration induced by VEGF-A and VEGF-C [8].
  • In this study, we investigated the expression of npn2 mRNA during new blood vessel growth in the retina and used npn2 knockout mice to assess the impact of deficiency of Npn2 on retinal NV [1].
  • The function of NP-2 in islet cell biology or tumourigenesis remains to be elucidated [5].
  • NP-2 expression has been recently localized to a subset of neuroendocrine cells in the gastrointestinal tract [5].
  • Paraffin-embedded tissue sections from 30 endocrine pancreatic tumours (EPTs) and from normal pancreas were immunostained with a rabbit polyclonal antibody generated towards NP-2 [5].

Associations of NRP2 with chemical compounds

  • Both np-2 forms bind VEGF(165) with high affinity in the presence of heparin (K(D) 1.3 x 10(-10) m) but not VEGF(121). np-2 also binds the heparin-binding form of placenta growth factor [13].
  • The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF [14].
  • In the colon, the np-2-expressing subpopulation of neuroendocrine cell is almost identical with the serotonin-producing subpopulation of neuroendocrine cells [15].
  • In the high-spin form of NP2, the proximal histidine plane is shown to be oriented 135 degrees clockwise from the heme N(II)-Fe-N(IV) axis, again for the B heme orientation [16].
  • Methotrexate (MTX) was conjugated to an anti-carcinoembryonic antigen monoclonal antibody (NP2) by using amino-dextran as an intermediate carrier [17].

Other interactions of NRP2


Analytical, diagnostic and therapeutic context of NRP2


  1. Deficiency of neuropilin 2 suppresses VEGF-induced retinal neovascularization. Shen, J., Samul, R., Zimmer, J., Liu, H., Liang, X., Hackett, S., Campochiaro, P.A. Mol. Med. (2004) [Pubmed]
  2. Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. Handa, A., Tokunaga, T., Tsuchida, T., Lee, Y.H., Kijima, H., Yamazaki, H., Ueyama, Y., Fukuda, H., Nakamura, M. Int. J. Oncol. (2000) [Pubmed]
  3. Semaphorin SEMA3F and VEGF have opposing effects on cell attachment and spreading. Nasarre, P., Constantin, B., Rouhaud, L., Harnois, T., Raymond, G., Drabkin, H.A., Bourmeyster, N., Roche, J. Neoplasia (2003) [Pubmed]
  4. Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B. Tomizawa, Y., Sekido, Y., Kondo, M., Gao, B., Yokota, J., Roche, J., Drabkin, H., Lerman, M.I., Gazdar, A.F., Minna, J.D. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours. Cohen, T., Herzog, Y., Brodzky, A., Greenson, J.K., Eldar, S., Gluzman-Poltorak, Z., Neufeld, G., Resnick, M.B. J. Pathol. (2002) [Pubmed]
  6. Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype. Bielenberg, D.R., Hida, Y., Shimizu, A., Kaipainen, A., Kreuter, M., Kim, C.C., Klagsbrun, M. J. Clin. Invest. (2004) [Pubmed]
  7. Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity. Giger, R.J., Urquhart, E.R., Gillespie, S.K., Levengood, D.V., Ginty, D.D., Kolodkin, A.L. Neuron (1998) [Pubmed]
  8. Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration. Favier, B., Alam, A., Barron, P., Bonnin, J., Laboudie, P., Fons, P., Mandron, M., Herault, J.P., Neufeld, G., Savi, P., Herbert, J.M., Bono, F. Blood (2006) [Pubmed]
  9. Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. Lin, L., Bu, L., Cai, C.L., Zhang, X., Evans, S. Dev. Biol. (2006) [Pubmed]
  10. Lymphangiogenic growth factors, receptors and therapies. Lohela, M., Saaristo, A., Veikkola, T., Alitalo, K. Thromb. Haemost. (2003) [Pubmed]
  11. A complementary peptide approach applied to the design of novel semaphorin/neuropilin antagonists. Williams, G., Eickholt, B.J., Maison, P., Prinjha, R., Walsh, F.S., Doherty, P. J. Neurochem. (2005) [Pubmed]
  12. High diversity of non-human leukocyte antigens in transplant-associated coronary artery disease. Bates, R.L., Frampton, G., Rose, M.L., Murphy, J.J. Transplantation (2003) [Pubmed]
  13. Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]. Gluzman-Poltorak, Z., Cohen, T., Herzog, Y., Neufeld, G. J. Biol. Chem. (2000) [Pubmed]
  14. The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF. Neufeld, G., Kessler, O., Herzog, Y. Adv. Exp. Med. Biol. (2002) [Pubmed]
  15. Neuroendocrine cells along the digestive tract express neuropilin-2. Cohen, T., Gluzman-Poltorak, Z., Brodzky, A., Meytal, V., Sabo, E., Misselevich, I., Hassoun, M., Boss, J.H., Resnick, M., Shneyvas, D., Eldar, S., Neufeld, G. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  16. Assignment of heme resonances and determination of the electronic structures of high- and low-spin nitrophorin 2 by 1H and 13C NMR spectroscopy: an explanation of the order of heme methyl resonances in high-spin ferriheme proteins. Shokhireva, T.K.h., Shokhirev, N.V., Walker, F.A. Biochemistry (2003) [Pubmed]
  17. Effects of methotrexate-carcinoembryonic-antigen-antibody immunoconjugates on GW-39 human tumors in nude mice. Shih, L.B., Goldenberg, D.M. Cancer Immunol. Immunother. (1990) [Pubmed]
  18. Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma. Kawakami, T., Tokunaga, T., Hatanaka, H., Kijima, H., Yamazaki, H., Abe, Y., Osamura, Y., Inoue, H., Ueyama, Y., Nakamura, M. Cancer (2002) [Pubmed]
  19. Differential expression of vascular endothelial growth factor (VEGF), endocrine gland derived-VEGF, and VEGF receptors in human placentas from normal and preeclamptic pregnancies. Chung, J.Y., Song, Y., Wang, Y., Magness, R.R., Zheng, J. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  20. Segregation of arterial and venous markers in subpopulations of blood islands before vessel formation. Herzog, Y., Guttmann-Raviv, N., Neufeld, G. Dev. Dyn. (2005) [Pubmed]
  21. Characterization and chromosomal localization of PTP-NP-2, a new isoform of protein tyrosine phosphatase-like receptor, expressed on synaptic boutons. Jiang, S., Tulloch, A.G., Kim, T.A., Fu, Y., Rogers, R., Gaskell, A., White, R.A., Avraham, H., Avraham, S. Gene (1998) [Pubmed]
  22. Primary structures of sperm-specific basic nuclear proteins and gene expression in Japanese newt, Cynops pyrrhogaster. Yoshinobu, K., Kondo, T., Takai, M., Katagiri, C., Tou, H., Abe, S.I., Takamune, K. Mol. Reprod. Dev. (1997) [Pubmed]
  23. RNA interference of the salivary gland nitrophorin 2 in the triatomine bug Rhodnius prolixus (Hemiptera: Reduviidae) by dsRNA ingestion or injection. Araujo, R.N., Santos, A., Pinto, F.S., Gontijo, N.F., Lehane, M.J., Pereira, M.H. Insect Biochem. Mol. Biol. (2006) [Pubmed]
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