Disease relevance of ARHGAP9

• Structural and biochemical analysis of Cellvibrio japonicus xylanase 10C: how variation in substrate-binding cleft influences the catalytic profile of family GH-10 xylanases [1].
• The present study demonstrates for the first time a protective effect of 10C allele against endometrial cancer [2].
• The hyperhomocysteinemia induced by the 10C diet was significantly suppressed by cysteine supplementation even at a 0.3% level, whereas cysteine did not decrease the plasma homocysteine concentration when added to the 30C diet [3].

High impact information on ARHGAP9

• The mCRY1 and mCRY2 genes are located on chromosome 10C and 2E, respectively, and are expressed in all mouse organs examined [4].
• Patients with the TGF-beta genotype 10 T/T 25 G/G or 10 T/C 25 G/G had a longer time to first rejection (median time to first rejection episode 321 days) than those with the TGF-beta genotype 10C/C 25 G/C or 10 C/C 25 C/C (median time to first rejection 88 days) [5].
• Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein [6].
• Our results indicate that ARHGAP9 is involved in regulating adhesion of hematopoietic cells to extracellular matrix [6].
• Exogenous expression of the entire coding region of ARHGAP9 into human leukemia KG-1 cells repressed adhesion of the cells to fibronectin and collagen IV [6].

Biological context of ARHGAP9

• Here we report isolation of a novel human gene, ARHGAP9, which encodes a protein containing a Rho-GTPase activating protein (Rho-GAP) domain, a src-homology 3 (SH3) domain, a pleckstrin homology (PH) region, and a WW domain [6].
• The relative risk of the genotype 10C/C was calculated as 2.51 [7].
• Gas chromatography of Krebs cycle and related acids on Silar 10C [8].
• Inhibition of apoptosis by coenzyme Q may also increase net cell proliferation and the 10C analog inhibits the permeability transition pore [9].
• Ten pairs were found carrying intergenomic translocations: (i) between the A and C genomes (chromosome pair 5A); (ii) between the C and D genomes (pairs 1C, 2C, 4C, 10C, and 16C); and (iii) between the D and C genomes (pairs 9D, 11D, 13D, and 14D) [10].

Anatomical context of ARHGAP9

• For example, coenzyme Q2 is known to decrease mitochondrial membrane potential whereas the analog with a 10C aliphatic side chain increases potential [9].
• We present time-lapse image sequences of COS-7 cells co-expressing both a marker of the Golgi complex (galactosyl transferase) fused to W7 and a marker of the nuclear envelope (lamin-B receptor) fused to 10C [11].

Associations of ARHGAP9 with chemical compounds

• The gas-liquid chromatographic behaviour of the methyl esters was studied on polar [Carbowax 20M, FFAP, DEGA, DEGS, Silar 10C (recently renamed as Apolar 10) and SP 2330], semi-polar (XE-60), and non-polar (SE-30, OV101 and Apiezon L) stationary phases [12].
• Five trimethylene-interrupted methyl octadecadiynoates, C18 delta-2a,-7a; delta-3a,-8a; delta-4a,-9a; delta-5a,-10a and delta-6a,-11a, and the corresponding cis,cis-octadecadienoates were synthesized, and their gas-liquid chromatographic properties were studied on Apiezon L, diethylene glycol succinate polyester and Silac 10C stationary phases [13].
• The 10C diet significantly increased the plasma homocysteine concentration as compared with the 30C diet [3].
• In contrast, 0.3% methionine supplementation of the 10C diet tended to increase the plasma homocysteine concentration [3].
• The effect of dietary supplementation with cysteine on the plasma homocysteine concentration was investigated in rats fed on 10% casein (10C) and 30% casein (30C) diets [3].

Analytical, diagnostic and therapeutic context of ARHGAP9

• The alditol acetates were separated by glass capillary gas chromatography on Silar 10C [14].
• The transevaporator procedure was used to obtain sample extracts which were chromatographed on a highly efficient glass column coated with Silar 10C (106 m x 0.25 mm I.D.). Differences in profiles between normal subjects and diabetic subjects on no drug therapy were noticed [15].
• Here, we describe the successful use of two photostable spectral GFP variants, W7 and 10C, in dual-color, time-lapse imaging of fusion proteins in living cells using either wide-field or confocal microscopy [11].
• Main predictors (P< 0.01) in this group (group-1: Child-Pugh score 10A, 10B, 10C) were graded (1, 2 or 3 points representing low, medium and high risk, respectively) and summarized as a Bonn TIPSS early mortality (BOTEM) score [16].
• To evaluate the possibilities of producing useful amounts of 10C (T1/2 = 19 s) for use as an on-line, steady state positron emission tomography (PET) tracer, the excitation function and the thick target yield for the 10B(p,n)10C reaction up to 30 MeV were measured using an adapted version of the stacked-foil technique [17].

References