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Gene Review

CBLN3  -  cerebellin 3 precursor

Homo sapiens

Synonyms: Cerebellin-3, UNQ755/PRO1486
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Disease relevance of CBLN3


High impact information on CBLN3

  • Therefore, cerebellin is not liberated from precerebellin by the classical dibasic amino acid proteolytic-cleavage mechanism seen in many neuropeptide precursors [3].
  • Three independent, overlapping cDNA clones have been isolated from a human cerebellum cDNA library that encode the cerebellin sequence [3].
  • Cerebellin enhances in vitro secretory activity of human adrenal gland [4].
  • Cerebellin concentration dependently increased basal catecholamine (norepinephrine and epinephrine) release by human adrenal slices, containing medullary chromaffin tissue, minimal and maximal effective concentrations being 10(-9) and 10(-7) mol/L [4].
  • Cerebellin did not affect basal steroid secretion of dispersed human adrenocortical cells, but it concentration dependently increased aldosterone and cortisol production by adrenal slices [4].

Biological context of CBLN3


Anatomical context of CBLN3


Associations of CBLN3 with chemical compounds

  • Cleavage at the N-terminus of the cerebellin sequence in Cbln1 yields trimeric complexes by separating the trimer-mediating C-terminal C1q domain from conserved N-terminal cysteine residues that mediate higher order oligomerization [9].
  • Cerebellin concentration-dependently (from 10(-9)to 10(-7)M) increased norepinephrine (but not epinephrine) and cyclic-AMP production by adrenomedullary tissue in vitro [8].
  • Cerebellin (10(-7)M) also elicited a significant rise in aldosterone and corticosterone output, and this effect was annulled by either the beta1-adrenoceptor antagonist l -alprenolol or H-89 [8].
  • Collectively, the present findings allow us to conclude that cerebellin 1) directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and 2) indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release [8].
  • The norepinephrine response to 10(-7)M cerebellin was blocked by the protein kinase (PK) A inhibitor H-89, but not by the phospholipase C inhibitor U-73122 or the PKC inhibitor calphostin-C [8].

Other interactions of CBLN3

  • Significant decreases in cerebellin and CRH concentrations were found in the cerebellar hemisphere of these diseases compared with controls [2].

Analytical, diagnostic and therapeutic context of CBLN3


  1. Cerebellin and cerebellin mRNA in the human brain, adrenal glands and the tumour tissues of adrenal tumour, ganglioneuroblastoma and neuroblastoma. Satoh, F., Takahashi, K., Murakami, O., Totsune, K., Ohneda, M., Mizuno, Y., Sone, M., Miura, Y., Takase, S., Hayashi, Y., Sasano, H., Mouri, T. J. Endocrinol. (1997) [Pubmed]
  2. Decrease in cerebellin and corticotropin-releasing hormone in the cerebellum of olivopontocerebellar atrophy and Shy-Drager syndrome. Mizuno, Y., Takahashi, K., Totsune, K., Ohneda, M., Konno, H., Murakami, O., Satoh, F., Sone, M., Takase, S., Itoyama, Y. Brain Res. (1995) [Pubmed]
  3. Precerebellin is a cerebellum-specific protein with similarity to the globular domain of complement C1q B chain. Urade, Y., Oberdick, J., Molinar-Rode, R., Morgan, J.I. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  4. Cerebellin enhances in vitro secretory activity of human adrenal gland. Mazzocchi, G., Andreis, P.G., De Caro, R., Aragona, F., Gottardo, L., Nussdorfer, G.G. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  5. Genomic structure and mapping of precerebellin and a precerebellin-related gene. Kavety, B., Jenkins, N.A., Fletcher, C.F., Copeland, N.G., Morgan, J.I. Brain Res. Mol. Brain Res. (1994) [Pubmed]
  6. Cerebellin in the rat adrenal gland: gene expression and effects of CER and [des-Ser1]CER on the secretion and growth of cultured adrenocortical cells. Rucinski, M., Albertin, G., Spinazzi, R., Ziolkowska, A., Nussdorfer, G.G., Malendowicz, L.K. Int. J. Mol. Med. (2005) [Pubmed]
  7. Cerebellin and related postsynaptic peptides in the brain of normal and neurodevelopmentally mutant vertebrates. Morgan, J.I., Slemmon, J.R., Danho, W., Hempstead, J., Berrebi, A.S., Mugnaini, E. Synapse (1988) [Pubmed]
  8. Cerebellin stimulates the secretory activity of the rat adrenal gland: in vitro and in vivo studies. Albertin, G., Malendowicz, L.K., Macchi, C., Markowska, A., Nussdorfer, G.G. Neuropeptides (2000) [Pubmed]
  9. The structure and proteolytic processing of Cbln1 complexes. Bao, D., Pang, Z., Morgan, J.I. J. Neurochem. (2005) [Pubmed]
  10. Purification and characterisation of cerebellins from human and porcine cerebellum. Yiangou, Y., Burnet, P., Nikou, G., Chrysanthou, B.J., Bloom, S.R. J. Neurochem. (1989) [Pubmed]
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