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Gene Review

SH3GL1  -  SH3-domain GRB2-like 1

Homo sapiens

Synonyms: CNSA1, EEN, EEN fusion partner of MLL, Endophilin-2, Endophilin-A2, ...
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Disease relevance of SH3GL1


High impact information on SH3GL1


Biological context of SH3GL1


Anatomical context of SH3GL1

  • CONCLUSION: EEN represents a rational alternative to TPN in patients who undergo upper gastrointestinal tract surgery for cancer and who clinically require postoperative artificial nutrition [2].

Associations of SH3GL1 with chemical compounds

  • EBP interacts simultaneously with EEN and Sos, a guanine-nucleotide exchange factor for Ras [7].
  • These processes were further enhanced when EEN was present together with the wildtype but not with the non-interactive proline mutant of BPGAP1 [8].

Physical interactions of SH3GL1


Other interactions of SH3GL1


Analytical, diagnostic and therapeutic context of SH3GL1


  1. EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia. So, C.W., Caldas, C., Liu, M.M., Chen, S.J., Huang, Q.H., Gu, L.J., Sham, M.H., Wiedemann, L.M., Chan, L.C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Early postoperative enteral nutrition improves gut oxygenation and reduces costs compared with total parenteral nutrition. Braga, M., Gianotti, L., Gentilini, O., Parisi, V., Salis, C., Di Carlo, V. Crit. Care Med. (2001) [Pubmed]
  3. Perioperative immunonutrition ameliorates the postoperative immune depression in patients with gastrointestinal system cancer (prospective clinical study in 42 patients). Ateş, E., Yilmaz, S., Erkasap, S., Ihtiyar, E., Kaya, Y., Pehlivan, T., Ustuner, Z., Yasar, B., Kiper, H. Acta Gastroenterol. Belg. (2004) [Pubmed]
  4. Aberrant transcriptional regulation of the MLL fusion partner EEN by AML1-ETO and its implication in leukemogenesis. Ma, L.H., Liu, H., Xiong, H., Chen, B., Zhang, X.W., Wang, Y.Y., Le, H.Y., Huang, Q.H., Zhang, Q.H., Li, B.L., Chen, Z., Chen, S.J. Blood (2007) [Pubmed]
  5. A novel SH3-containing human gene family preferentially expressed in the central nervous system. Giachino, C., Lantelme, E., Lanzetti, L., Saccone, S., Bella Valle, G., Migone, N. Genomics (1997) [Pubmed]
  6. The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis. So, C.W., So, C.K., Cheung, N., Chew, S.L., Sham, M.H., Chan, L.C. Leukemia (2000) [Pubmed]
  7. Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein. Yam, J.W., Jin, D.Y., So, C.W., Chan, L.C. Blood (2004) [Pubmed]
  8. Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain. Lua, B.L., Low, B.C. J. Cell. Sci. (2005) [Pubmed]
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