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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Precipitation


High impact information on Precipitation

  • Sequential precipitations demonstrated that Qa-2 is distinct from H-2D and H-2K molecules [6].
  • Through reciprocal precipitations using a variety of antibodies against RPTP mu, cadherins, and catenins, we show that RPTP mu does not interact with cadherin/catenin complexes, even when assayed under very mild lysis conditions [7].
  • Similar to the animal SR proteins, this group of proteins can be isolated by two salt precipitations [8].
  • To biochemically characterize p75, we have directly isolated IL-2R using affinity precipitations with immobilized IL-2 [9].
  • Culture supernatants of the internally [35S]methionine-labeled E-9M(+) line were subjected to a combined purification of sequential ammonium sulfate precipitations, followed by affinity chromatography [10].

Chemical compound and disease context of Precipitation


Biological context of Precipitation


Anatomical context of Precipitation


Associations of Precipitation with chemical compounds


Gene context of Precipitation

  • Affinity precipitations suggest that only a discrete fraction of cellular presenilin is present in the active gamma-secretase complex and that both gamma(40)- and gamma(42)-activities are mediated by the same molecular entity [26].
  • GST-protein precipitations from cell lysates confirmed that GST-PLC-gamma1(SH3) associated with endogenously expressed Tnk1 [27].
  • Specific RHAMM variants of 85- and 58-kDa size were shown to bind avidly to HA following CPC precipitations [3].
  • A precursor-product relationship of both pSMC-1 and pSMC-2 to ASGP-1 was suggested by combined precipitations with anti-ASGP-1 and peanut agglutinin, which precipitates ASGP-1 specifically [28].
  • The lipid requirements for insertion of the proteolipid were studied, therefore, after delipidation by several precipitations with isooctane, a nondenaturing solvent [29].

Analytical, diagnostic and therapeutic context of Precipitation


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  2. gamma-Hexachlorocyclohexane inhibition of the calcium fluxes at the desensitized mouse neuromuscular junction. Lievremont, M., Barnier, J.V., Potus, J. Toxicol. Appl. Pharmacol. (1984) [Pubmed]
  3. Hyaluronate receptors mediating glioma cell migration and proliferation. Akiyama, Y., Jung, S., Salhia, B., Lee, S., Hubbard, S., Taylor, M., Mainprize, T., Akaishi, K., van Furth, W., Rutka, J.T. J. Neurooncol. (2001) [Pubmed]
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  6. Molecular similarities between the Qa-2 alloantigen and other gene products of the 17th chromosome of the mouse. Michaelson, J., Flaherty, L., Vitetta, E., Poulik, M.D. J. Exp. Med. (1977) [Pubmed]
  7. Lack of association between receptor protein tyrosine phosphatase RPTP mu and cadherins. Zondag, G.C., Moolenaar, W.H., Gebbink, M.F. J. Cell Biol. (1996) [Pubmed]
  8. Pre-mRNA splicing in plants: characterization of Ser/Arg splicing factors. Lopato, S., Mayeda, A., Krainer, A.R., Barta, A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  9. Evidence for additional subunits associated to the mouse interleukin 2 receptor p55/p75 complex. Saragovi, H., Malek, T.R. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  10. Partial purification and characterization of an antigen-specific helper factor synthesized by a T-cell continuous line. Lifshitz, R., Apte, R.N., Mozes, E. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  11. A simple method for the extraction of polysaccharide B from Brucella cells for use in the radial immunodiffusion test diagnosis of bovine brucellosis. Diaz, R., Toyos, J., Salvó, M.D., Pardo, M.L. Ann. Rech. Vet. (1981) [Pubmed]
  12. Isolation of Trypanosoma brucei CYC2 and CYC3 cyclin genes by rescue of a yeast G(1) cyclin mutant. Functional characterization of CYC2. Van Hellemond, J.J., Neuville, P., Schwarz, R.T., Matthews, K.R., Mottram, J.C. J. Biol. Chem. (2000) [Pubmed]
  13. Partial purification of a chorionic gonadotropin-like protein from bovine cotyledons. Ailenberg, M., Shemesh, M. Biol. Reprod. (1983) [Pubmed]
  14. A procedure for large-scale plasmid isolation without using ultracentrifugation. Chakrabarti, A., Sitaric, S., Ohi, S. Biotechnol. Appl. Biochem. (1992) [Pubmed]
  15. Monoclonal antibodies to O4 antigen of Vibrio parahaemolyticus. Ogawa, S., Koshikawa, T., Watabe, K., Yamazoe, M., Torii, M., Sakato, N., Azuma, T., Fujio, H. Microbiol. Immunol. (1988) [Pubmed]
  16. Electrogenic calcium transport in plasma membrane of rat pancreatic acinar cells. Bayerdörffer, E., Eckhardt, L., Haase, W., Schulz, I. J. Membr. Biol. (1985) [Pubmed]
  17. A one-step preparative method for separating SER 6-phosphorylated HMG 14 from unphosphorylated HMG 14 and in vitro phosphorylation reaction components. Bofinger, D.P., Fucile, N.W., Spaulding, S.W. Anal. Biochem. (1988) [Pubmed]
  18. Properties of 2'5' oligoadenylate synthetase. Jutesen, J., Ferbus, D., Thang, M.N. Ann. N. Y. Acad. Sci. (1980) [Pubmed]
  19. Interleukin-6 production is upregulated by interaction between disc tissue and macrophages. Takada, T., Nishida, K., Doita, M., Miyamoto, H., Kurosaka, M. Spine. (2004) [Pubmed]
  20. Structural organization and fine distribution of lymphatic vessels in periodontal tissues of the rat and monkey: a histochemical study. Zhang, B., Miura, M., Ji, R.C., Matsumoto, Y., Yanagisawa, S., Kato, S. Okajimas folia anatomica Japonica. (2000) [Pubmed]
  21. Alpha 2-macroglobulin binds and inhibits activated protein C. Hoogendoorn, H., Toh, C.H., Nesheim, M.E., Giles, A.R. Blood (1991) [Pubmed]
  22. Nuclear translocation of the estrogen receptor in autonomous C3H mouse mammary tumors. Vignon, F., Rochefort, H. Cancer Res. (1978) [Pubmed]
  23. Preparation and some properties of equine platelet tropomyosin. Côté, G.P., Smillie, L.B. J. Biol. Chem. (1981) [Pubmed]
  24. Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1. Thomä, N.H., Iakovenko, A., Goody, R.S., Alexandrov, K. J. Biol. Chem. (2001) [Pubmed]
  25. Anthramycin inhibition of restriction endonuclease cleavage and its use as a reversible blocking agent in DNA constructions. Sumner, W., Bennett, G.N. Nucleic Acids Res. (1981) [Pubmed]
  26. In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand. Beher, D., Fricker, M., Nadin, A., Clarke, E.E., Wrigley, J.D., Li, Y.M., Culvenor, J.G., Masters, C.L., Harrison, T., Shearman, M.S. Biochemistry (2003) [Pubmed]
  27. Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1. Felschow, D.M., Civin, C.I., Hoehn, G.T. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  28. Biosynthesis of the cell surface sialomucin complex of ascites 13762 rat mammary adenocarcinoma cells from a high molecular weight precursor. Sheng, Z.Q., Hull, S.R., Carraway, K.L. J. Biol. Chem. (1990) [Pubmed]
  29. Myelin proteins in reverse micelles: tight lipid association required for insertion of the Folch-Pi proteolipid into a membrane-mimetic system. Vacher, M., Waks, M., Nicot, C. J. Neurochem. (1989) [Pubmed]
  30. Large scale purification of hog renin. Physicochemical characterization. Corvol, P., Devaux, C., Ito, T., Sicard, P., Ducloux, J., Menard, J. Circ. Res. (1977) [Pubmed]
  31. Purification and characterization of protein methylesterase from rat kidney. Gagnon, C., Harbour, D., Camato, R. J. Biol. Chem. (1984) [Pubmed]
  32. Opacification of a silicone intraocular lens caused by calcium deposits on the optic. Wackernagel, W., Ettinger, K., Weitgasser, U., Bakir, B.G., Schmut, O., Goessler, W., Faschinger, C. Journal of cataract and refractive surgery. (2004) [Pubmed]
  33. Demonstrations of the production of specific antibodies to poly(I).poly(C) in rabbits. Kitagawa, Y., Okuhara, E. J. Biochem. (1980) [Pubmed]
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