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Gene Review

Smarca2  -  SWI/SNF related, matrix associated, actin...

Mus musculus

Synonyms: 2610209L14Rik, ATP-dependent helicase SMARCA2, BAF190B, BRG1-associated factor 190B, Baf190b, ...
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Disease relevance of Smarca2


High impact information on Smarca2


Biological context of Smarca2


Anatomical context of Smarca2

  • We show that BRG1 is selectively required for epithelial-mesenchymal interactions in limb patterning, and during keratinocyte terminal differentiation, in which BRM can partially substitute for BRG1 [8].
  • The decline in hepatic progenitor cell proliferation owing to the formation of a complex involving cEBP-alpha and the chromatin remodelling factor brahma (Brm) inhibits the regenerative capacity of aged liver [9].

Associations of Smarca2 with chemical compounds


Other interactions of Smarca2


Analytical, diagnostic and therapeutic context of Smarca2


  1. Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing. Harikrishnan, K.N., Chow, M.Z., Baker, E.K., Pal, S., Bassal, S., Brasacchio, D., Wang, L., Craig, J.M., Jones, P.L., Sif, S., El-Osta, A. Nat. Genet. (2005) [Pubmed]
  2. SWI/SNF chromatin-remodeling factors induce changes in DNA methylation to promote transcriptional activation. Banine, F., Bartlett, C., Gunawardena, R., Muchardt, C., Yaniv, M., Knudsen, E.S., Weissman, B.E., Sherman, L.S. Cancer Res. (2005) [Pubmed]
  3. Cyclin A repression in quiescent cells is associated with chromatin remodeling of its promoter and requires Brahma/SNF2alpha. Coisy, M., Roure, V., Ribot, M., Philips, A., Muchardt, C., Blanchard, J.M., Dantonel, J.C. Mol. Cell (2004) [Pubmed]
  4. A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. Bultman, S., Gebuhr, T., Yee, D., La Mantia, C., Nicholson, J., Gilliam, A., Randazzo, F., Metzger, D., Chambon, P., Crabtree, G., Magnuson, T. Mol. Cell (2000) [Pubmed]
  5. Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha). Reyes, J.C., Barra, J., Muchardt, C., Camus, A., Babinet, C., Yaniv, M. EMBO J. (1998) [Pubmed]
  6. ras transformation is associated with decreased expression of the brm/SNF2alpha ATPase from the mammalian SWI-SNF complex. Muchardt, C., Bourachot, B., Reyes, J.C., Yaniv, M. EMBO J. (1998) [Pubmed]
  7. The activity of mammalian brm/SNF2alpha is dependent on a high-mobility-group protein I/Y-like DNA binding domain. Bourachot, B., Yaniv, M., Muchardt, C. Mol. Cell. Biol. (1999) [Pubmed]
  8. Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation. Indra, A.K., Dupé, V., Bornert, J.M., Messaddeq, N., Yaniv, M., Mark, M., Chambon, P., Metzger, D. Development (2005) [Pubmed]
  9. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Conboy, I.M., Conboy, M.J., Wagers, A.J., Girma, E.R., Weissman, I.L., Rando, T.A. Nature (2005) [Pubmed]
  10. Ethanol modifies the effect of handling stress on gene expression: problems in the analysis of two-way gene expression studies in mouse brain. Rulten, S.L., Ripley, T.L., Manerakis, E., Stephens, D.N., Mayne, L.V. Brain Res. (2006) [Pubmed]
  11. Effect of Brahma Rasayana on antioxidant systems and cytokine levels in mice during cyclophosphamide administration. Rekha, P.S., Kuttan, G., Kuttan, R. J. Exp. Clin. Cancer Res. (2001) [Pubmed]
  12. Antioxidant activity of brahma rasayana. Rekha, P.S., Kuttan, G., Kuttan, R. Indian J. Exp. Biol. (2001) [Pubmed]
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