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Gene Review

Ift74  -  intraflagellar transport 74

Mus musculus

Synonyms: 1700029H06Rik, CMG-1, Capillary morphogenesis gene 1 protein, Ccdc2, Cmg1, ...
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Disease relevance of Ift74


High impact information on Ift74


Biological context of Ift74


Anatomical context of Ift74


Associations of Ift74 with chemical compounds


Other interactions of Ift74

  • Studies of capillary morphogenesis and angiogenesis in vitro have suggested a role for E-selectin (CD62E) in the process of differentiation into tube-like structures [11].
  • When CMG-1 expression was attenuated in a mouse spermatocyte-derived cell line, GC-2spd(ts), by a target-specific short interfering RNA, the morphology of the cells was changed and the expression of cyclin D2 was abrogated [10].


  1. Angiopoietin correlates with glomerular capillary loss in anti-glomerular basement membrane glomerulonephritis. Yuan, H.T., Tipping, P.G., Li, X.Z., Long, D.A., Woolf, A.S. Kidney Int. (2002) [Pubmed]
  2. Hypoxia-induced gene activity in disused oxidative muscle. D??pp, C., Gassmann, M., Hoppeler, H., Fl??ck, M. Adv. Exp. Med. Biol. (2006) [Pubmed]
  3. In vivo and in vitro models of Mammalian angiogenesis. Hoang, M.V., Senger, D.R. Methods Mol. Biol. (2005) [Pubmed]
  4. Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress. Blais, J.D., Addison, C.L., Edge, R., Falls, T., Zhao, H., Wary, K., Koumenis, C., Harding, H.P., Ron, D., Holcik, M., Bell, J.C. Mol. Cell. Biol. (2006) [Pubmed]
  5. Enforced expression of tissue inhibitor of matrix metalloproteinase-3 affects functional capillary morphogenesis and inhibits tumor growth in a murine tumor model. Spurbeck, W.W., Ng, C.Y., Strom, T.S., Vanin, E.F., Davidoff, A.M. Blood (2002) [Pubmed]
  6. Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase. Kanda, S., Mochizuki, Y., Suematsu, T., Miyata, Y., Nomata, K., Kanetake, H. J. Biol. Chem. (2003) [Pubmed]
  7. Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling. Phillips, R.S., Ramos, S.B., Blackshear, P.J. J. Biol. Chem. (2002) [Pubmed]
  8. Wound healing: a model for the study of diabetic angiopathy. Arquilla, E.R., Weringer, E.J., Nakajo, M. Diabetes (1976) [Pubmed]
  9. Role of focal adhesion formation in migration and morphogenesis of endothelial cells. Kanda, S., Miyata, Y., Kanetake, H. Cell. Signal. (2004) [Pubmed]
  10. Capillary morphogenesis gene (CMG)-1 is among the genes differentially expressed in mouse male germ line stem cells and embryonic stem cells. Fujino, R.S., Ishikawa, Y., Tanaka, K., Kanatsu-Shinohara, M., Tamura, K., Kogo, H., Shinohara, T., Hara, T. Mol. Reprod. Dev. (2006) [Pubmed]
  11. Microvascular endothelial cells from E-selectin-deficient mice form tubes in vitro. Gerritsen, M.E., Shen, C.P., Atkinson, W.J., Padgett, R.C., Gimbrone, M.A., Milstone, D.S. Lab. Invest. (1996) [Pubmed]
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