Gene Review:
SYP - synaptophysin
Homo sapiens
Synonyms:
MRX96, MRXSYP, Major synaptic vesicle protein p38, Synaptophysin
Vajtai,
Kappeler,
Lukes,
Arnold,
Lüthy,
Leibundgut,
Yao,
O'Herron,
Coleman,
Ulfig,
Chan,
Lukinius,
Stridsberg,
Wilander,
Khan,
Tischler,
Patwardhan,
DeLellis,
Varoqui,
Erickson,
Portela-Gomes,
Stridsberg,
Johansson,
Grimelius,
Thiele,
Hannah,
Fahrenholz,
Huttner,
Ijzer,
Roskams,
Molenbeek,
Ultee,
Penning,
Rothuizen,
van den Ingh,
Struble,
Nathan,
Cady,
Cheng,
McAsey,
Webster,
Shannon Weickert,
Herman,
Hyde,
Kleinman,
- Immunocytochemical detection of calcineurin and microtubule-associated protein 2 in central neurocytoma. Goto, S., Nagahiro, S., Ushio, Y., Kitaoka, M., Nishio, S., Fukui, M. J. Neurooncol. (1993)
- Synaptophysin: A novel marker for human and rat hepatic stellate cells. Cassiman, D., van Pelt, J., De Vos, R., Van Lommel, F., Desmet, V., Yap, S.H., Roskams, T. Am. J. Pathol. (1999)
- Morphological characterisation of portal myofibroblasts and hepatic stellate cells in the normal dog liver. Ijzer, J., Roskams, T., Molenbeek, R.F., Ultee, T., Penning, L.C., Rothuizen, J., van den Ingh, T.S. Comparative hepatology (2006)
- Regulation of synaptophysin degradation by mammalian homologues of seven in absentia. Wheeler, T.C., Chin, L.S., Li, Y., Roudabush, F.L., Li, L. J. Biol. Chem. (2002)
- Synaptophysin expression in the human spinal cord. Diagnostic implications of an immunohistochemical study. Zhang, P.J., Rosenblum, M.K. Am. J. Surg. Pathol. (1996)
- Growth-associated protein 43 (GAP-43) and synaptophysin alterations in the dentate gyrus of patients with schizophrenia. Chambers, J.S., Thomas, D., Saland, L., Neve, R.L., Perrone-Bizzozero, N.I. Prog. Neuropsychopharmacol. Biol. Psychiatry (2005)
- Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins. Eastwood, S.L., Harrison, P.J. Brain Res. Bull. (2001)
- MAP2 and synaptophysin protein expression following motor learning suggests dynamic regulation and distinct alterations coinciding with synaptogenesis. Derksen, M.J., Ward, N.L., Hartle, K.D., Ivanco, T.L. Neurobiology of learning and memory (2007)
- APP with Kunitz type protease inhibitor domain (KPI) correlates with neuritic plaque density but not with cortical synaptophysin immunoreactivity in Alzheimer's disease and non-demented aged subjects: a multifactorial analysis. Zhan, S.S., Sandbrink, R., Beyreuther, K., Schmitt, H.P. Clin. Neuropathol. (1995)
- Synaptophysin expression in the striatum in Huntington's disease. Goto, S., Hirano, A. Acta Neuropathol. (1990)
- Topogenesis and sorting of synaptophysin: synthesis of a synaptic vesicle protein from a gene transfected into nonneuroendocrine cells. Leube, R.E., Wiedenmann, B., Franke, W.W. Cell (1989)
- Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Wiedenmann, B., Franke, W.W. Cell (1985)
- Estradiol regulation of astroglia and apolipoprotein E: An important role in neuronal regeneration. Struble, R.G., Nathan, B.P., Cady, C., Cheng, X., McAsey, M. Exp. Gerontol. (2007)
- A comparison of synaptophysin, chromogranin, and L-dopa decarboxylase as markers for neuroendocrine differentiation in lung cancer cell lines. Jensen, S.M., Gazdar, A.F., Cuttitta, F., Russell, E.K., Linnoila, R.I. Cancer Res. (1990)
- A clinicopathologic study of three carcinoid tumors metastatic to the orbit. Immunohistochemical, ultrastructural, and DNA flow cytometric studies. Shetlar, D.J., Font, R.L., Ordóñez, N., el-Naggar, A., Boniuk, M. Ophthalmology (1990)
- Primitive neuroectodermal tumors of the central nervous system. Patterns of expression of neuroendocrine markers, and all classes of intermediate filament proteins. Gould, V.E., Jansson, D.S., Molenaar, W.M., Rorke, L.B., Trojanowski, J.Q., Lee, V.M., Packer, R.J., Franke, W.W. Lab. Invest. (1990)
- Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp. Fisher, S.E., Ciccodicola, A., Tanaka, K., Curci, A., Desicato, S., D'urso, M., Craig, I.W. Genomics (1997)
- RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site. Lietz, M., Hohl, M., Thiel, G. Eur. J. Biochem. (2003)
- Synaptophysin and GAP-43 mRNA levels in the hippocampus of subjects with schizophrenia. Webster, M.J., Shannon Weickert, C., Herman, M.M., Hyde, T.M., Kleinman, J.E. Schizophr. Res. (2001)
- Synaptic and dendritic pathology in murine retroviral encephalitis. Nagra, R.M., Masliah, E., Wiley, C.A. Exp. Neurol. (1993)
- Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles. Thiele, C., Hannah, M.J., Fahrenholz, F., Huttner, W.B. Nat. Cell Biol. (2000)
- Regulation by neurotransmitter receptors of serotonergic or catecholaminergic neuronal cell differentiation. Mouillet-Richard, S., Mutel, V., Loric, S., Tournois, C., Launay, J.M., Kellermann, O. J. Biol. Chem. (2000)
- Neuroprotective Effects of Angiotensin II Type 1 Receptor (AT1R) Blocker, Telmisartan, via Modulating AT1R and AT2R Signaling in Retinal Inflammation. Kurihara, T., Ozawa, Y., Shinoda, K., Nagai, N., Inoue, M., Oike, Y., Tsubota, K., Ishida, S., Okano, H. Invest. Ophthalmol. Vis. Sci. (2006)
- Glucocorticoid exposure at the dose used clinically alters cytoskeletal proteins and presynaptic terminals in the fetal baboon brain. Antonow-Schlorke, I., Schwab, M., Li, C., Nathanielsz, P.W. J. Physiol. (Lond.) (2003)
- Unloading kinesin transported cargoes from the tubulin track via the inflammatory c-Jun N-terminal kinase pathway. Stagi, M., Gorlovoy, P., Larionov, S., Takahashi, K., Neumann, H. FASEB J. (2006)
- Cadherin binding sites of plakoglobin: localization, specificity and role in targeting to adhering junctions. Troyanovsky, R.B., Chitaev, N.A., Troyanovsky, S.M. J. Cell. Sci. (1996)
- Synaptophysin regulates clathrin-independent endocytosis of synaptic vesicles. Daly, C., Sugimori, M., Moreira, J.E., Ziff, E.B., Llinás, R. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Immunohistochemical study of the hippocampus in parkinsonism-dementia complex on Guam. Ito, H., Goto, S., Hirano, A., Yen, S.H. Journal of geriatric psychiatry and neurology. (1991)
- The cytoplasmic tail of the vesicular acetylcholine transporter contains a synaptic vesicle targeting signal. Varoqui, H., Erickson, J.D. J. Biol. Chem. (1998)
- Differential expression of synaptoporin and synaptophysin in primary sensory neurons and up-regulation of synaptoporin after peripheral nerve injury. Sun, T., Xiao, H.S., Zhou, P.B., Lu, Y.J., Bao, L., Zhang, X. Neuroscience (2006)
- Immunocytochemical localization of synaptophysin in human hypophyses and pituitary adenomas. Stefaneanu, L., Ryan, N., Kovacs, K. Arch. Pathol. Lab. Med. (1988)
- SWI/SNF complex is essential for NRSF-mediated suppression of neuronal genes in human nonsmall cell lung carcinoma cell lines. Watanabe, H., Mizutani, T., Haraguchi, T., Yamamichi, N., Minoguchi, S., Yamamichi-Nishina, M., Mori, N., Kameda, T., Sugiyama, T., Iba, H. Oncogene (2006)
- Papillary glioneuronal tumor. Vajtai, I., Kappeler, A., Lukes, A., Arnold, M., Lüthy, A.R., Leibundgut, K. Pathol. Res. Pract. (2006)
- Differentiation of human adult skin-derived neuronal precursors into mature neurons. Gingras, M., Champigny, M.F., Berthod, F. J. Cell. Physiol. (2007)
- Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain. Yao, P.J., O'Herron, T.M., Coleman, P.D. Neurobiol. Aging (2003)
- Cellular expression and specific intragranular localization of chromogranin A, chromogranin B, and synaptophysin during ontogeny of pancreatic islet cells: an ultrastructural study. Lukinius, A., Stridsberg, M., Wilander, E. Pancreas (2003)
- Expression of a kinase anchoring protein 79 and synaptophysin in the developing human red nucleus. Ulfig, N., Chan, W.Y. Neurosignals (2002)
- Calcitonin immunoreactivity in neoplastic and hyperplastic parathyroid glands: an immunohistochemical study. Khan, A., Tischler, A.S., Patwardhan, N.A., DeLellis, R.A. Endocr. Pathol. (2003)
- Detection of synaptophysin-producing cells in human thymus by immunohistochemistry and nonradioactive in situ hybridization. Maggiano, N., Lauriola, L., Serra, F.G., Ricci, R., Capelli, A., Ranelletti, F.O. J. Histochem. Cytochem. (1999)
- Co-localization of synaptophysin with different neuroendocrine hormones in the human gastrointestinal tract. Portela-Gomes, G.M., Stridsberg, M., Johansson, H., Grimelius, L. Histochem. Cell Biol. (1999)
- Stargazin mutation impairs cerebellar synaptogenesis, synaptic maturation and synaptic protein distribution. Meng, H., Walker, N., Su, Y., Qiao, X. Brain Res. (2006)