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Gene Review

TMBIM6  -  transmembrane BAX inhibitor motif...

Homo sapiens

Synonyms: BAXI1, BI-1, BI1, Bax inhibitor 1, TEGT, ...
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Disease relevance of TEGT


High impact information on TEGT

  • When overexpressed in mammalian cells, BI-1 suppressed apoptosis included by Bax, etoposide, staurosporine, and growth factor deprivation, but not by Fas (CD95) [4].
  • BI-1 thus represents a new type of regulator of cell death pathways controlled by Bcl-2 and Bax [4].
  • By exploiting this phenotype, we have identified a novel human Bax inhibitor, BI-1 [4].
  • BI-1 is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments and is predominantly localized to intracellular membranes, similar to Bcl-2 family proteins [4].
  • Chemical induction of resistance to Bgh by soil drench treatment with 2,6-dichloroisonicotinic acid led to down-regulation of the expression level of BI-1 [5].

Biological context of TEGT


Anatomical context of TEGT


Associations of TEGT with chemical compounds

  • Among them, we selected two candidates the TEGT BI-1 (testis enhanced gene transcript Bax Inhibitor-1) and the CD63 gene in order to further confirm their differential expression under tamoxifen effects [7].
  • BI-1 appears to suppress cell death induced by mitochondrial dysfunction, reactive oxygen species or elevated cytosolic Ca(2+) levels [9].

Other interactions of TEGT

  • Inhibition of mitochondrial membrane permeabilization by overexpression of Bcl-2 or expression of the cytomegalovirus-encoded protein vMIA (viral mitochondrial inhibitor of apoptosis), which acts as a specific Bax inhibitor, prevented the induction of cell death by the combination of hTERT depletion and chemotherapeutic agents [10].
  • Novel genes involved in the regulation of apoptosis were found for the first time to be up-regulated by gonadotrophin stimulation, including: BAX inhibitor-1, granulysin and apoptosis repressor with caspase recruitment domain (ARC) [11].
  • The mechanism for these BI-1-associated functions involves the expression of heme oxygenase-1 (HO-1) through nuclear factor erythroid 2-related factor 2 [12].

Analytical, diagnostic and therapeutic context of TEGT


  1. Transcriptome analysis of human gastric cancer. Oh, J.H., Yang, J.O., Hahn, Y., Kim, M.R., Byun, S.S., Jeon, Y.J., Kim, J.M., Song, K.S., Noh, S.M., Kim, S., Yoo, H.S., Kim, Y.S., Kim, N.S. Mamm. Genome (2005) [Pubmed]
  2. Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells. Grzmil, M., Thelen, P., Hemmerlein, B., Schweyer, S., Voigt, S., Mury, D., Burfeind, P. Am. J. Pathol. (2003) [Pubmed]
  3. Expression of the Bax inhibitor-1 gene in pulmonary adenocarcinoma. Tanaka, R., Ishiyama, T., Uchihara, T., Inadome, Y., Iijima, T., Morishita, Y., Kano, J., Goya, T., Noguchi, M. Cancer (2006) [Pubmed]
  4. Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. Xu, Q., Reed, J.C. Mol. Cell (1998) [Pubmed]
  5. Overexpression of barley BAX inhibitor 1 induces breakdown of mlo-mediated penetration resistance to Blumeria graminis. Hückelhoven, R., Dechert, C., Kogel, K.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. Identification of a novel conserved human gene, TEGT. Walter, L., Marynen, P., Szpirer, J., Levan, G., Günther, E. Genomics (1995) [Pubmed]
  7. Differential gene expression assessed by cDNA microarray analysis in breast cancer tissue under tamoxifen treatment. del Carmen Garcia Molina Wolgien, M., da Silva, I.D., Villanova, F.E., Yumi Otsuka, A., Borra, R.C., Lima Reis, L.F., Carvalho, A.F., Baracat, E.C., Gebrim, L.H. Eur. J. Gynaecol. Oncol. (2005) [Pubmed]
  8. Preliminary characterization of the protein encoded by human testis-enhanced gene transcript (TEGT). Cowling, R.T., Birnboim, H.C. Mol. Membr. Biol. (1998) [Pubmed]
  9. BAX Inhibitor-1, an ancient cell death suppressor in animals and plants with prokaryotic relatives. Hückelhoven, R. Apoptosis (2004) [Pubmed]
  10. hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway. Massard, C., Zermati, Y., Pauleau, A.L., Larochette, N., Métivier, D., Sabatier, L., Kroemer, G., Soria, J.C. Oncogene (2006) [Pubmed]
  11. Gonadotrophin-induced gene regulation in human granulosa cells obtained from IVF patients. Modulation of steroidogenic genes, cytoskeletal genes and genes coding for apoptotic signalling and protein kinases. Sasson, R., Rimon, E., Dantes, A., Cohen, T., Shinder, V., Land-Bracha, A., Amsterdam, A. Mol. Hum. Reprod. (2004) [Pubmed]
  12. Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expression. Lee, G.H., Kim, H.K., Chae, S.W., Kim, D.S., Ha, K.C., Cuddy, M., Kress, C., Reed, J.C., Kim, H.R., Chae, H.J. J. Biol. Chem. (2007) [Pubmed]
  13. The Bax inhibitor-1 gene is differentially regulated in adult testis and developing lung by two alternative TATA-less promoters. Jean, J.C., Oakes, S.M., Joyce-Brady, M. Genomics (1999) [Pubmed]
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