Disease relevance of VEZF1

• Coronary angiography (CAG) revealed stenosis of the left anterior descending artery (LAD) and the first diagonal artery (DB1) [1].

Psychiatry related information on VEZF1

• Fluorescent analogues (DB1 and TA1) of the secondary metabolites didemnin B (DB) and tamandarin A (TA) were synthesized to investigate the potential chemical defense mechanisms of tunicates in the family Didemnidae [2].

High impact information on VEZF1

• Electrophoretic mobility shift assay, with specific antibodies, showed that DB1 constitutively binds to this region whereas EGR1 binds in a T-cell activation-dependent manner [3].
• Overexpression of DB1 in Jurkat cells had no detectable effect on the transcription activity of the IL-3 promoter, in a transient-transfection assay [3].
• Promoter point mutations may be responsible for cancer-specific loss of hDB-1 expression [4].
• In order to characterize the specificity of expression of the neurotransmitter biosynthetic gene dopamine beta-hydroxylase (DBH), the identification of proteins that interact with the DB1 enhancer was initiated [5].
• A homeobox-containing cDNA was isolated from a PC12 expression cDNA library screened with the DB1 enhancer [5].

Biological context of VEZF1

• The RhoB-binding domain in DB1 was located in a functionally undefined region upstream and separable from its zinc finger DNA binding domain [6].
• The DB1 enhancer contains two binding sites for the Arix homeodomain, and both sites contribute to basal activity of the DBH promoter [5].
• Accurate mass measurements of TRX II, DS2, DS5, and DB1 verified the expected DNA-encoded protein sequences (average mass error 1.3 ppm) and allowed unequivocal assignment of the disulfides without chemical reduction and subsequent alkylation of the expected cross-links [7].
• The DR7-associated Dw specificities, Dw11, Dw17 and DB1 were investigated with regard to DRB- and DQB-gene polymorphism, as revealed by RFLP analysis using the restriction enzyme TaqI [8].
• Based on 16S rRNA gene sequencing and scanning electron microscopy, the isolate was found to belong to the genus Pseudonocardia and assigned the strain designation DB1 [9].

Anatomical context of VEZF1

• Vezf1/DB1 could be identified with a specific antibody in nuclear complexes from endothelial cells that bound to this element [10].
• This cell line, notably derived from an individual with a deletion of the 21-hydroxylase B-gene (21-OHB), caries the HLA haplotype Bw47, DR7, DQw2, DB1, but displayed a DRB RFLP otherwise found in association with Dw17 [8].
• OPCABG [left internal thoracic artery (LITA) to DB1 and LAD] was performed [1].

Associations of VEZF1 with chemical compounds

• Skin levels should not be considered as absorbed material for DHA or DB1, while 7NTPC requires further investigation [11].
• For DB1, penetration studies found approximately 10% (ethanol vehicle) and 3% (formulation vehicle) of the applied dose localized in mainly the stratum corneum after 24 h [11].
• The present study investigated the fate of three chemicals [dihydroxyacetone (DHA), 7-(2H-naphtho[1,2-d]triazol-2-yl)-3-phenylcoumarin (7NTPC), and disperse blue 1 (DB1)] in an in vitro absorption study [11].
• Strain DB1 grew on benzoate, dibenzothiophene sulfone, and hexadecanoic acid, but it could not grow on benzofuran, dibenzothiophene, dibenzothiophene sulfoxide, hexadecane, indole, naphthalene, phenol, 2-sulfobenzoic acid, sulfolane, benzothiophene, or 3- or 5-methylbenzothiophenes [9].
• CTGF was exported from DB1 cells as early as 5 min after synthesis and all isoforms were readily purified from conditioned medium by sequential steps of heparin affinity, cation exchange, and reverse-phase chromatography [12].

Other interactions of VEZF1

• Functional interaction between RhoB and the transcription factor DB1 [6].

Analytical, diagnostic and therapeutic context of VEZF1

• The DB1 monoclonal antibody did not prolong heart allograft survival in the (LEW/BN)F1 to LEW combination, even when used at high doses (2 mg/rat x 9 days) [13].
• Retention and detector response factor data have been given for 188 compounds on the DB1 capillary column using a dual nitrogen--phosphorus and flame ionization detection system [14].
• The isolated nitrosamines are converted to the corresponding trimethylsilyl (TMS) derivatives and determined by gas chromatography (GC) on a DB1 column coupled with a thermal energy analyzer (GC-TEA) [15].

References