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Gene Review

VEZF1  -  vascular endothelial zinc finger 1

Homo sapiens

Synonyms: DB1, Vascular endothelial zinc finger 1, ZNF161, Zinc finger protein 161
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Disease relevance of VEZF1


Psychiatry related information on VEZF1

  • Fluorescent analogues (DB1 and TA1) of the secondary metabolites didemnin B (DB) and tamandarin A (TA) were synthesized to investigate the potential chemical defense mechanisms of tunicates in the family Didemnidae [2].

High impact information on VEZF1


Biological context of VEZF1

  • The RhoB-binding domain in DB1 was located in a functionally undefined region upstream and separable from its zinc finger DNA binding domain [6].
  • The DB1 enhancer contains two binding sites for the Arix homeodomain, and both sites contribute to basal activity of the DBH promoter [5].
  • Accurate mass measurements of TRX II, DS2, DS5, and DB1 verified the expected DNA-encoded protein sequences (average mass error 1.3 ppm) and allowed unequivocal assignment of the disulfides without chemical reduction and subsequent alkylation of the expected cross-links [7].
  • The DR7-associated Dw specificities, Dw11, Dw17 and DB1 were investigated with regard to DRB- and DQB-gene polymorphism, as revealed by RFLP analysis using the restriction enzyme TaqI [8].
  • Based on 16S rRNA gene sequencing and scanning electron microscopy, the isolate was found to belong to the genus Pseudonocardia and assigned the strain designation DB1 [9].

Anatomical context of VEZF1

  • Vezf1/DB1 could be identified with a specific antibody in nuclear complexes from endothelial cells that bound to this element [10].
  • This cell line, notably derived from an individual with a deletion of the 21-hydroxylase B-gene (21-OHB), caries the HLA haplotype Bw47, DR7, DQw2, DB1, but displayed a DRB RFLP otherwise found in association with Dw17 [8].
  • OPCABG [left internal thoracic artery (LITA) to DB1 and LAD] was performed [1].

Associations of VEZF1 with chemical compounds


Other interactions of VEZF1

  • Functional interaction between RhoB and the transcription factor DB1 [6].

Analytical, diagnostic and therapeutic context of VEZF1

  • The DB1 monoclonal antibody did not prolong heart allograft survival in the (LEW/BN)F1 to LEW combination, even when used at high doses (2 mg/rat x 9 days) [13].
  • Retention and detector response factor data have been given for 188 compounds on the DB1 capillary column using a dual nitrogen--phosphorus and flame ionization detection system [14].
  • The isolated nitrosamines are converted to the corresponding trimethylsilyl (TMS) derivatives and determined by gas chromatography (GC) on a DB1 column coupled with a thermal energy analyzer (GC-TEA) [15].


  1. Off-pump coronary artery bypass grafting in two renal transplant patients. Sakao, T., Kashu, Y., Nakagawa, H., Kajiwara, S. The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi. (2003) [Pubmed]
  2. Chemical defense in ascidians of the didemnidae family. Joullié, M.M., Leonard, M.S., Portonovo, P., Liang, B., Ding, X., La Clair, J.J. Bioconjug. Chem. (2003) [Pubmed]
  3. Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter. Koyano-Nakagawa, N., Nishida, J., Baldwin, D., Arai, K., Yokota, T. Mol. Cell. Biol. (1994) [Pubmed]
  4. Human {beta}-Defensin-1, a Potential Chromosome 8p Tumor Suppressor: Control of Transcription and Induction of Apoptosis in Renal Cell Carcinoma. Sun, C.Q., Arnold, R., Fernandez-Golarz, C., Parrish, A.B., Almekinder, T., He, J., Ho, S.M., Svoboda, P., Pohl, J., Marshall, F.F., Petros, J.A. Cancer Res. (2006) [Pubmed]
  5. A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neurotransmitter biosynthetic genes. Zellmer, E., Zhang, Z., Greco, D., Rhodes, J., Cassel, S., Lewis, E.J. J. Neurosci. (1995) [Pubmed]
  6. Functional interaction between RhoB and the transcription factor DB1. Lebowitz, P.F., Prendergast, G.C. Cell Adhes. Commun. (1998) [Pubmed]
  7. Characterization of mutant xylanases using fourier transform ion cyclotron resonance mass spectrometry: stabilizing contributions of disulfide bridges and N-terminal extensions. Jänis, J., Turunen, O., Leisola, M., Derrick, P.J., Rouvinen, J., Vainiotalo, P. Biochemistry (2004) [Pubmed]
  8. Analysis of HLA-DRB and -DQB gene RFLPs in DR7 homozygous cell lines: associations with Dw11, Dw17 and DB1. Carlsson, B., Wallin, J. Tissue Antigens (1991) [Pubmed]
  9. Biodegradation of benzothiophene sulfones by a filamentous bacterium. Bressler, D.C., Leskiw, B.K., Fedorak, P.M. Can. J. Microbiol. (1999) [Pubmed]
  10. Vezf1/DB1 is an endothelial cell-specific transcription factor that regulates expression of the endothelin-1 promoter. Aitsebaomo, J., Kingsley-Kallesen, M.L., Wu, Y., Quertermous, T., Patterson, C. J. Biol. Chem. (2001) [Pubmed]
  11. Fate of chemicals in skin after dermal application: does the in vitro skin reservoir affect the estimate of systemic absorption? Yourick, J.J., Koenig, M.L., Yourick, D.L., Bronaugh, R.L. Toxicol. Appl. Pharmacol. (2004) [Pubmed]
  12. Establishment of a recombinant expression system for connective tissue growth factor (CTGF) that models CTGF processing in utero. Ball, D.K., Moussad, E.E., Rageh, M.A., Kemper, S.A., Brigstock, D.R. Reproduction (2003) [Pubmed]
  13. Effect of recombinant interferon gamma and interleukin-2 and of a monoclonal antibody against interferon gamma on the rat immune response against heart allografts. Paineau, J., Priestley, C., Fabre, J., Chevalier, S., van der Meide, P., Schellekens, H., Jacques, Y., Soulillou, J.P. J. Heart Lung Transplant. (1991) [Pubmed]
  14. Use of dual-column fused-silica capillary gas chromatography in combination with detector response factors for analytical toxicology. Perrigo, B.J., Peel, H.W., Ballantyne, D.J. J. Chromatogr. (1985) [Pubmed]
  15. Gas chromatographic determination of N-nitrosodialkanolamines in herbicide Di- or trialkanolamine formulations. Wigfield, Y.Y., Lacroix, M.D., Lanouette, M., Gurprasad, N.P. Journal - Association of Official Analytical Chemists. (1988) [Pubmed]
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