Disease relevance of MALL

• Highlighted genes such as SLA, LST1, and BENE might be important in the development of neural tube defects [1].
• Comment on "Irreversible ocular toxicity from single challenge dose of desferrioxamine" by C. Bene et al [2].
• Down-regulation of members of glycolipid-enriched membrane raft gene family, MAL and BENE, in cervical squamous cell cancers [3].
• METHODS: Two hundred and fifty postmenopausal women were enrolled from the "Bene Essere Donna" Center and grouped according to the absence (Group I, n = 175; mean age 54.6 +/- 3.5) or presence of mild to moderate hypertension (Group II, n = 75; mean age 54.1 +/- 4.5) [4].

High impact information on MALL

• Nota bene: neuroscience. For time is the longest distance between two places [5].
• Caspase substrates have bene identified that induce each of the classic features of apoptosis, including membrane blebbing, cell body shrinkage, and DNA fragmentation [6].
• Coimmunoprecipitation experiments revealed that BENE interacted with caveolin-1 [7].
• Together, these features highlight the BENE proteolipid as being an element of the machinery for raft-mediated trafficking in endothelial cells [7].
• In this study we have used a newly generated monoclonal antibody to investigate an unedited member of this family, named BENE, which was found to be expressed in endothelial-like ECV304 cells and normal human endothelium [7].

Biological context of MALL

• Other genes, including all three major histocompatibility class I (HLA) genes, BENE, and an unnamed gene related to CNIL(CORNICHON-like), display an opposite expression profile (i.e., they are upregulated in the DNA-PK-deficient cell line, but show low levels of expression in both M059K and in the PRKDC-complemented cell line) [8].
• Computer-aided analysis and database searches revealed that MAL belongs to a larger gene family which also includes plasmolipin, BENE and the expressed sequence tag (EST) H09290 [9].
• Variation in DQ beta alleles associated with DQw3 was previously described by characteristic RFLP patterns for a DQ beta bene [10].
• These results suggest that down-regulation of MAL and BENE genes, which are essential components of the cellular polarized sorting system, play an important role in human cervical squamous cell cancer development [3].
• Genetics, history, and identity: the case of the Bene Israel and the Lemba [11].

Anatomical context of MALL

• Moreover, using subcellular fractionation of transiently transfected COS-7 cells, both MAL and BENE were identified in detergent-resistant membranes [12].

Associations of MALL with chemical compounds

• In response to cell surface cholesterol oxidation, BENE redistributed to the dilated vesicular structures that concentrate most of the caveolin-1 originally on the cell surface [7].

Co-localisations of MALL

• Confocal immunofluorescence and electron microscopic analyses indicated that BENE mainly accumulated into intracellular vesicular/tubular structures that partially colocalize with internal caveolin-1 [7].

Other interactions of MALL

• After cessation of cholesterol oxidation, a detectable fraction of the BENE molecules migrated to the plasmalemma accompanying caveolin-1 and then returned progressively to its steady state distribution [7].

References