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Gene Review

Mcam  -  melanoma cell adhesion molecule

Rattus norvegicus

Synonyms: CD146, Cell surface glycoprotein MUC18, Gicerin, Melanoma cell adhesion molecule, Melanoma-associated antigen MUC18, ...
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Disease relevance of Mcam


High impact information on Mcam


Biological context of Mcam


Anatomical context of Mcam

  • And we also showed neurite promotion activity of gicerin from hippocampal neurons [3].
  • Here, we found that the expression of gicerin was increased in the rat carotid arteries after balloon injury [5].
  • Immunohistochemical analysis demonstrated that the expression of gicerin protein was increased in the medial smooth muscle cells prior to the formation of neointima one week after the injury and was also increased in the luminal edge of the neointima after two weeks [5].
  • We found that hypoglossal nerve injury resulted in a significant increase in gicerin expression [4].

Associations of Mcam with chemical compounds


Analytical, diagnostic and therapeutic context of Mcam


  1. Gicerin, an Ig-superfamily cell adhesion molecule, promotes the invasive and metastatic activities of a mouse fibroblast cell line. Tsukamoto, Y., Egawa, M., Hiroi, S., Furuya, M., Tsuchiya, S., Sasaki, F., Miki, N., Taira, E. J. Cell. Physiol. (2003) [Pubmed]
  2. Gicerin/CD146 is involved in neurite extension of NGF-treated PC12 cells. Taira, E., Kohama, K., Tsukamoto, Y., Okumura, S., Miki, N. J. Cell. Physiol. (2005) [Pubmed]
  3. Characterization of Gicerin/MUC18/CD146 in the rat nervous system. Taira, E., Kohama, K., Tsukamoto, Y., Okumura, S., Miki, N. J. Cell. Physiol. (2004) [Pubmed]
  4. Expression of gicerin, a novel cell adhesion molecule, is upregulated in the astrocytes after hypoglossal nerve injury in rats. Li, B.S., Su, Q.N., Kiyama, H., Miki, N., Robinow, D.R., Zhang, L. Neurosci. Lett. (1999) [Pubmed]
  5. Induction of gicerin/CD146 in the rat carotid artery after balloon injury. Okumura, S., Kohama, K., Kim, S., Iwao, H., Miki, N., Taira, E. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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