Disease relevance of Mcam

• Furthermore, l-gicerin transfectants markedly enhanced metastasis to the lung [1].

High impact information on Mcam

• Over-expression of gicerin also promotes neurite extension by gicerin-gicerin homophilic interaction [2].
• Gicerin/CD146 is a cell adhesion molecule, which belongs to the immunoglobulin (Ig) superfamily [2].
• We also found that the expression of gicerin in PC12 cells is induced by NGF [2].
• Gicerin is expressed in the hippocampal cells, Purkinje cells, and sensory neurons of a spinal chord of an adult rat, while expressed most abundantly in the lung [3].
• Gicerin, an Ig-superfamily cell adhesion molecule, promotes the invasive and metastatic activities of a mouse fibroblast cell line [1].

Biological context of Mcam

• Gicerin is a cell adhesion molecule of an immunoglobulin (Ig) superfamily isolated from a chicken [3].
• Compared with parental cells, both gicerin isoform transfectants showed an enhanced cell growth and invaded deeply into surrounding tissues from implanted sites in both animal models [1].
• The results indicate that gicerin is up-regulated during nerve regeneration, suggesting that gicerin expressed in the reactive astrocytes might be involved in the processes of nerve regeneration [4].

Anatomical context of Mcam

• And we also showed neurite promotion activity of gicerin from hippocampal neurons [3].
• Here, we found that the expression of gicerin was increased in the rat carotid arteries after balloon injury [5].
• Immunohistochemical analysis demonstrated that the expression of gicerin protein was increased in the medial smooth muscle cells prior to the formation of neointima one week after the injury and was also increased in the luminal edge of the neointima after two weeks [5].
• We found that hypoglossal nerve injury resulted in a significant increase in gicerin expression [4].

Associations of Mcam with chemical compounds

• Gicerin is an integral membrane glycoprotein which mediates cell-cell and cell-extracellular matrix (ECM) interactions in the nervous system [4].

Analytical, diagnostic and therapeutic context of Mcam

• We studied gicerin expression in the hypoglossal nucleus post transection using in situ hybridization and immunocytochemistry [4].

References