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Gene Review

Mcam  -  melanoma cell adhesion molecule

Mus musculus

Synonyms: 1-gicerin, AV025631, CD146, CD149, Cell surface glycoprotein MUC18, ...
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Disease relevance of Mcam


High impact information on Mcam


Biological context of Mcam

  • Gicerin is a cell adhesion molecule, which has five immunoglobulin-like loop structures in an extracellular domain followed by a single transmembrane domain and a short cytoplasmic tail [6].
  • A fragment of 16 kbp genomic clone contained 8 kbp gicerin gene composed of 16 exons with 6 kbp upstream region [6].
  • Genomic cloning revealed that two isoforms of gicerin were generated by an alternative splicing of exon 15 results in cytoplasmic domains composed of either 63 or 21 amino acids [6].
  • AP-2-driven downregulation of the melanoma cell adhesion molecule promoter, however, did not depend only on a functional SCA element [2].
  • Collectively, these findings suggest that TGF-beta1 may therefore regulate gicerin expression in hepatocytes leading to liver regeneration by cell-cell or cell-ECM interactions [7].

Anatomical context of Mcam

  • We have reported that gicerin participates in neurite extension and structural organization of the nervous system, and its expression in the nervous system is high during the development and dramatically decreased after birth [6].
  • As for an expressional regulation of gicerin, we found that the mRNA content of gicerin in PC12 cells was regulated by cAMP [6].
  • Expression of gicerin enhances the invasive and metastatic activities of a mouse mammary carcinoma cell line [1].
  • The normal mammary glands of mice were negative for gicerin, but sporadic mammary carcinoma cells expressed gicerin strongly on their surface [1].
  • Previous studies demonstrated that gicerin showed a doublet band of 82 and 90 kDa in chicken gizzard smooth muscle [5].

Associations of Mcam with chemical compounds

  • Moesin was coprecipitated with glutathione S-transferase-fusion proteins of the l-gicerin cytoplasmic domain but not with the s-gicerin cytoplasmic domain [8].
  • Using a combination of chloramphenicol acetyl transferase reporter assays and DNA mobility shift experiments, we investigated the role played by three putative melanoma cell adhesion molecule regulatory elements, namely the initiator sequence, the SCA element, and the ASp element [2].
  • Immunohistochemically, gicerin protein appeared in the regenerating hepatocytes of carbon tetrachloride (CCl4)-induced acute hepatitis, while it was scarcely expressed in the hepatocytes of normal mouse liver [7].

Other interactions of Mcam

  • When cells were double-stained with antibodies to gicerin and moesin, a microvilli-specific protein, the staining of l-gicerin corresponded to that of moesin in the elongated microvilli [8].
  • Gicerin, an Ig-superfamily cell adhesion molecule, appears transiently in embryonic tissues including those of the nervous, urogenital, respiratory and digestive systems, and it promotes neurite extension, cell migration and epithelialization through its cell adhesive activities [7].

Analytical, diagnostic and therapeutic context of Mcam


  1. Expression of gicerin enhances the invasive and metastatic activities of a mouse mammary carcinoma cell line. Tsukamoto, Y., Sakaiuchi, T., Hiroi, S., Furuya, M., Tsuchiya, S., Sasaki, F., Miki, N., Taira, E. Int. J. Oncol. (2003) [Pubmed]
  2. Role of the initiator element in the regulation of the melanoma cell adhesion molecule gene. Karlen, S., Braathen, L.R. J. Invest. Dermatol. (2000) [Pubmed]
  3. Molecular cloning and functional expression of gicerin, a novel cell adhesion molecule that binds to neurite outgrowth factor. Taira, E., Takaha, N., Taniura, H., Kim, C.H., Miki, N. Neuron (1994) [Pubmed]
  4. Functional endothelial cells derived from rhesus monkey embryonic stem cells. Kaufman, D.S., Lewis, R.L., Hanson, E.T., Auerbach, R., Plendl, J., Thomson, J.A. Blood (2004) [Pubmed]
  5. Expression and functional analysis of a novel isoform of gicerin, an immunoglobulin superfamily cell adhesion molecule. Taira, E., Nagino, T., Taniura, H., Takaha, N., Kim, C.H., Kuo, C.H., Li, B.S., Higuchi, H., Miki, N. J. Biol. Chem. (1995) [Pubmed]
  6. Molecular cloning and analysis of the mouse gicerin gene. Kohama, K., Tsukamoto, Y., Furuya, M., Okamura, K., Tanaka, H., Miki, N., Taira, E. Neurochem. Int. (2005) [Pubmed]
  7. Involvement of transforming growth factor-beta in the expression of gicerin, a cell adhesion molecule, in the regeneration of hepatocytes. Tsuchiya, S., Tsukamoto, Y., Taira, E., Lamarre, J. Int. J. Mol. Med. (2007) [Pubmed]
  8. Involvement of gicerin in the extension of microvilli. Okumura, S., Muraoka, O., Tsukamoto, Y., Tanaka, H., Kohama, K., Miki, N., Taira, E. Exp. Cell Res. (2001) [Pubmed]
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