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MeSH Review

Hypoglossal Nerve

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Disease relevance of Hypoglossal Nerve


Psychiatry related information on Hypoglossal Nerve

  • The duration of periodic inspiratory motor activity recorded from the hypoglossal nerve was unaffected by dizocilpine (1-100 microM) or the competitive NMDA antagonist D- or DL-2-amino-5-phosphonopentanoic acid (100 microM and 1 mM), although respiratory frequency decreased [6].

High impact information on Hypoglossal Nerve

  • Immunochemical demonstration of reversible reduction in choline acetyltransferase concentration in rat hypoglossal nucleus after hypoglossal nerve transection [7].
  • Regeneration of axotomized hypoglossal nerve in vivo was significantly retarded by the administration of anti-IL-6R antibody [8].
  • Application of ATP to the hypoglossal nucleus of mouse medullary slices and anesthetized rats produced a suramin-sensitive excitation of hypoglossal nerve activity [9].
  • Because of its widespread presence in neurons of the brain stem and spinal cord, androgen receptors may have important roles in regulation of neuron physiology beyond the sphere of reproductive function, including mediating androgen effects on regeneration of the hypoglossal nerve reported previously [10].
  • b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve [11].

Chemical compound and disease context of Hypoglossal Nerve


Biological context of Hypoglossal Nerve


Anatomical context of Hypoglossal Nerve


Associations of Hypoglossal Nerve with chemical compounds

  • The 2A antagonist, MDL-100907, dropped intrinsic hypoglossal nerve respiratory activity by 61 +/- 6% (p < 0.001) and suppressed serotonin excitation of hypoglossal nerve activity (p < 0.05) [24].
  • In vivo GABA application to the SCG with a hypoglossal nerve implanted in the presence of intact preganglionic afferent synapses exerted a significant modulatory effect on the AChE activity and its molecular forms [15].
  • Following hypoglossal nerve transection in adult rats, immunoreactivity for complement factor C3 and one of its degradation products C3d as well as C4d and immunoglobulin G (IgG) was observed in the ipsilateral hypoglossal nucleus [25].
  • We suggest that halothane mediates changes in respiratory hypoglossal nerve discharge by altering activity of premotor neurons in the Kölliker-Fuse and intertrigeminal region [26].
  • Increased glucose use in the hypoglossal nucleus after hypoglossal nerve transection in aged rats [27].

Gene context of Hypoglossal Nerve


Analytical, diagnostic and therapeutic context of Hypoglossal Nerve


  1. Long-term intermittent hypoxia: reduced excitatory hypoglossal nerve output. Veasey, S.C., Zhan, G., Fenik, P., Pratico, D. Am. J. Respir. Crit. Care Med. (2004) [Pubmed]
  2. An unusual case of systemic lupus erythematosus with isolated hypoglossal nerve palsy, fulminant acute pneumonitis, and pulmonary amyloidosis. Chan, C.N., Li, E., Lai, F.M., Pang, J.A. Ann. Rheum. Dis. (1989) [Pubmed]
  3. The medullary vascular syndromes revisited. Gan, R., Noronha, A. J. Neurol. (1995) [Pubmed]
  4. gamma-Aminobutyric acid enables synaptogenesis in the intact superior cervical ganglion of the adult rat. Dames, W., Joó, F., Fehér, O., Toldi, J., Wolff, J.R. Neurosci. Lett. (1985) [Pubmed]
  5. Surgery on a saccular vertebral artery-posterior inferior cerebellar artery aneurysm via the transcondylar fossa (supracondylar transjugular tubercle) approach or the transcondylar approach: surgical results and indications for using two different lateral skull base approaches. Matsushima, T., Matsukado, K., Natori, Y., Inamura, T., Hitotsumatsu, T., Fukui, M. J. Neurosurg. (2001) [Pubmed]
  6. Involvement of NMDA receptors in the respiratory phase transition is different in the adult guinea pig in vivo and in the isolated brain stem preparation. Morin-Surun, M.P., Boudinot, E., Kato, F., Foutz, A.S., Denavit-Saubié, M. J. Neurophysiol. (1995) [Pubmed]
  7. Immunochemical demonstration of reversible reduction in choline acetyltransferase concentration in rat hypoglossal nucleus after hypoglossal nerve transection. Wooten, G.F., Park, D.H., Joh, T.H., Reis, D.J. Nature (1978) [Pubmed]
  8. Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma. Hirota, H., Kiyama, H., Kishimoto, T., Taga, T. J. Exp. Med. (1996) [Pubmed]
  9. P2 receptor excitation of rodent hypoglossal motoneuron activity in vitro and in vivo: a molecular physiological analysis. Funk, G.D., Kanjhan, R., Walsh, C., Lipski, J., Comer, A.M., Parkis, M.A., Housley, G.D. J. Neurosci. (1997) [Pubmed]
  10. Androgen receptor levels in cranial nerve nuclei and tongue muscles in rats. Yu, W.H., McGinnis, M.Y. J. Neurosci. (1986) [Pubmed]
  11. b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve. Okada, M., Itoh Mi, M., Haraguchi, M., Okajima, T., Inoue, M., Oishi, H., Matsuda, Y., Iwamoto, T., Kawano, T., Fukumoto, S., Miyazaki, H., Furukawa, K., Aizawa, S., Furukawa, K. J. Biol. Chem. (2002) [Pubmed]
  12. The influence of halothane and thiopental on respiratory-related nerve activities in decerebrate cats. Masuda, A., Ito, Y., Haji, A., Takeda, R. Acta anaesthesiologica Scandinavica. (1989) [Pubmed]
  13. Hypoglossal nerve injury caused by halo-suspension traction. A case report. Ginsburg, G.M., Bassett, G.S. Spine. (1998) [Pubmed]
  14. Infusion of cytosine-arabinoside into the cerebrospinal fluid of the rat brain inhibits the microglial cell proliferation after hypoglossal nerve injury. Svensson, M., Aldskogius, H. Glia (1993) [Pubmed]
  15. Modulation of the acetylcholine system in the superior cervical ganglion of rat: effects of GABA and hypoglossal nerve implantation after in vivo GABA treatment. Kása, P., Dames, W., Rakonczay, Z., Gulya, K., Joó, F., Wolff, J.R. J. Neurochem. (1985) [Pubmed]
  16. Collapsin response mediator protein-2 accelerates axon regeneration of nerve-injured motor neurons of rat. Suzuki, Y., Nakagomi, S., Namikawa, K., Kiryu-Seo, S., Inagaki, N., Kaibuchi, K., Aizawa, H., Kikuchi, K., Kiyama, H. J. Neurochem. (2003) [Pubmed]
  17. Expression of fibroblast growth factor-2 in hypoglossal motoneurons is stimulated by peripheral nerve injury. Huber, K., Meisinger, C., Grothe, C. J. Comp. Neurol. (1997) [Pubmed]
  18. Anterograde axonal transport of glial cell line-derived neurotrophic factor and its receptors in rat hypoglossal nerve. Russell, F.D., Koishi, K., Jiang, Y., McLennan, I.S. Neuroscience (2000) [Pubmed]
  19. Chromatolysis in alcoholic encephalopathies. Pellagra-like changes in 22 cases. Hauw, J.J., De Baecque, C., Hausser-Hauw, C., Serdaru, M. Brain (1988) [Pubmed]
  20. Differential response of neutral endopeptidase 24.11 ("enkephalinase"), and cholinergic and opioidergic markers to hypoglossal axotomy. Back, S.A., Gorenstein, C. J. Comp. Neurol. (1994) [Pubmed]
  21. Effect of ethanol upon respiratory-related hypoglossal nerve output of neonatal rat brain stem slices. Gibson, I.C., Berger, A.J. J. Neurophysiol. (2000) [Pubmed]
  22. The neck-tongue syndrome. Orrell, R.W., Marsden, C.D. J. Neurol. Neurosurg. Psychiatr. (1994) [Pubmed]
  23. Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury. Ji, J.F., He, B.P., Dheen, S.T., Tay, S.S. Stem Cells (2004) [Pubmed]
  24. Pharmacological characterization of serotonergic receptor activity in the hypoglossal nucleus. Fenik, P., Veasey, S.C. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  25. Evidence for activation of the complement cascade in the hypoglossal nucleus following peripheral nerve injury. Svensson, M., Aldskogius, H. J. Neuroimmunol. (1992) [Pubmed]
  26. Effects of anesthetics on hypoglossal nerve discharge and c-Fos expression in brainstem hypoglossal premotor neurons. Roda, F., Pio, J., Bianchi, A.L., Gestreau, C. J. Comp. Neurol. (2004) [Pubmed]
  27. Increased glucose use in the hypoglossal nucleus after hypoglossal nerve transection in aged rats. Singer, P.A., Mehler, S. Exp. Neurol. (1990) [Pubmed]
  28. Expression of mRNA for Akt, serine-threonine protein kinase, in the brain during development and its transient enhancement following axotomy of hypoglossal nerve. Owada, Y., Utsunomiya, A., Yoshimoto, T., Kondo, H. J. Mol. Neurosci. (1997) [Pubmed]
  29. Central infusions of brain-derived neurotrophic factor and neurotrophin-4/5, but not nerve growth factor and neurotrophin-3, prevent loss of the cholinergic phenotype in injured adult motor neurons. Tuszynski, M.H., Mafong, E., Meyer, S. Neuroscience (1996) [Pubmed]
  30. Macrophage stimulating protein is a novel neurotrophic factor. Stella, M.C., Vercelli, A., Repici, M., Follenzi, A., Comoglio, P.M. Mol. Biol. Cell (2001) [Pubmed]
  31. Brain-derived neurotrophic factor spares choline acetyltransferase mRNA following axotomy of motor neurons in vivo. Wang, W., Salvaterra, P.M., Loera, S., Chiu, A.Y. J. Neurosci. Res. (1997) [Pubmed]
  32. Analysis of neurotrophic effects of hepatocyte growth factor in the adult hypoglossal nerve axotomy model. Okura, Y., Arimoto, H., Tanuma, N., Matsumoto, K., Nakamura, T., Yamashima, T., Miyazawa, T., Matsumoto, Y. Eur. J. Neurosci. (1999) [Pubmed]
  33. CEP-1347/KT7515 prevents motor neuronal programmed cell death and injury-induced dedifferentiation in vivo. Glicksman, M.A., Chiu, A.Y., Dionne, C.A., Harty, M., Kaneko, M., Murakata, C., Oppenheim, R.W., Prevette, D., Sengelaub, D.R., Vaught, J.L., Neff, N.T. J. Neurobiol. (1998) [Pubmed]
  34. Changes in phrenic, mylohyoid, and hypoglossal nerve activities that follow intravenous infusions of aminophylline. St John, W.M., Bartlett, D. Exp. Neurol. (1987) [Pubmed]
  35. Transection or electrical stimulation of the hypoglossal nerve increases glial fibrillary acidic protein immunoreactivity in the hypoglossal nucleus. Hall, L.L., Borke, R.C., Anders, J.J. Brain Res. (1989) [Pubmed]
  36. Differential expression of calbindin and calmodulin in motoneurons after hypoglossal axotomy. Dassesse, D., Cuvelier, L., Krebs, C., Streppel, M., Guntinas-Lichius, O., Neiss, W.F., Pochet, R. Brain Res. (1998) [Pubmed]
  37. Radiation-induced cranial nerve palsy: hypoglossal nerve and vocal cord palsies. Takimoto, T., Saito, Y., Suzuki, M., Nishimura, T. The Journal of laryngology and otology. (1991) [Pubmed]
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