The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Stmn4  -  stathmin-like 4

Rattus norvegicus

Synonyms: Lagl, RB3, Rb3, Stathmin-4, Stathmin-like protein B3
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Stmn4


High impact information on Stmn4


Biological context of Stmn4

  • 30 of Rb1, Rb2 or Rb3 extracted from the leaf and stem of Panax ginseng C A Meyer restored the action potentials (AP) of free radical damaged cells to normal, indicating their antioxidative action [4].

Anatomical context of Stmn4

  • Furthermore, RB3 mRNA is undetectable in PC12 cells, whereas SCG10 mRNA increases after treatment with nerve growth factor, inducing neuronal differentiation [5].
  • Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neuron-specific member of the SCG10 family, by its N-terminal domain [3].

Associations of Stmn4 with chemical compounds

  • On normal myocardial cells, Rb1, Rb2, Rb3 20 inhibited the AP and spontaneous contractility, (suggesting the Ca channel blockade action of panaxadiol saponins) [4].

Other interactions of Stmn4

  • The pattern of expression of the RB3 transcript is very different from that of the three other members of the stathmin family [6].
  • In the postnatal retina, the level of SCLIP increased, whereas the level of RB3 remained low [7].
  • When brain-derived neurotrophic factor was administrated intravitreously, the induction of RB3 mRNA sustained up to 7 days after axotomy, although the peak induction level was unchanged [2].

Analytical, diagnostic and therapeutic context of Stmn4


WikiGenes - Universities