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Gene Review

Stmn4  -  stathmin-like 4

Rattus norvegicus

Synonyms: Lagl, RB3, Rb3, Stathmin-4, Stathmin-like protein B3
 
 
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Disease relevance of Stmn4

 

High impact information on Stmn4

 

Biological context of Stmn4

  • 30 micrograms.ml-1 of Rb1, Rb2 or Rb3 extracted from the leaf and stem of Panax ginseng C A Meyer restored the action potentials (AP) of free radical damaged cells to normal, indicating their antioxidative action [4].
 

Anatomical context of Stmn4

  • Furthermore, RB3 mRNA is undetectable in PC12 cells, whereas SCG10 mRNA increases after treatment with nerve growth factor, inducing neuronal differentiation [5].
  • Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neuron-specific member of the SCG10 family, by its N-terminal domain [3].
 

Associations of Stmn4 with chemical compounds

  • On normal myocardial cells, Rb1, Rb2, Rb3 20 micrograms.ml-1 inhibited the AP and spontaneous contractility, (suggesting the Ca channel blockade action of panaxadiol saponins) [4].
 

Other interactions of Stmn4

  • The pattern of expression of the RB3 transcript is very different from that of the three other members of the stathmin family [6].
  • In the postnatal retina, the level of SCLIP increased, whereas the level of RB3 remained low [7].
  • When brain-derived neurotrophic factor was administrated intravitreously, the induction of RB3 mRNA sustained up to 7 days after axotomy, although the peak induction level was unchanged [2].
 

Analytical, diagnostic and therapeutic context of Stmn4

References

 
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