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Gene Review

Stmn1  -  stathmin 1

Rattus norvegicus

Synonyms: Lap18, Leukemia-associated phosphoprotein p18, Metablastin, OP18, Oncoprotein 18, ...
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Disease relevance of Stmn1


High impact information on Stmn1


Biological context of Stmn1

  • As proof of the principle that this approach could identify genes whose upregulation was necessary for nonadherent growth, we investigated one gene, stathmin whose upregulation by cJun was observed only under these conditions [7].
  • By two-dimensional electrophoresis, phosphorylation of Op18/stathmin was found to be increased upon the expression of constitutively active ASK1 (ASK1DeltaN) in PC12 cells [8].
  • Stathmin expression clearly increases in the uterus when stimulated by embryo implantation and decidualization and may play a role in the early stages of pregnancy [9].
  • In physiological conditions, stathmin immunoreactivity was observed in polysialic acid-neural cell adhesion molecule-positive migratory progenitors in the subventricular zone, and its expression progressively decreased as the cells matured into oligodendrocytes (OLs) [1].
  • Neuronal activity induction of the stathmin-like gene RB3 in the rat hippocampus: possible role in neuronal plasticity [10].

Anatomical context of Stmn1

  • At the molecular level, each possesses a specific "stathmin-like domain" and, with the exception of stathmin, various combinations of N-terminal extensions involved in their association with intracellular membrane compartments [11].
  • Stathmin mRNA was highly expressed both in the RGCs and other interneurons [12].
  • In situ hybridization revealed that GAP-43 and all of the SCG10-related family mRNAs were present in the retinal ganglion cells (RGCs) at all stages of retinal development, and that stathmin mRNA was present in mitotic neuroblastic cells [12].
  • Phosphoproteins of the stathmin family are important regulators of microtubule dynamics, in particular in the developing and mature nervous system [13].
  • Two separate motifs cooperate to target stathmin-related proteins to the Golgi complex [13].

Associations of Stmn1 with chemical compounds

  • Consistently, we found that all four isoforms of p38 directly phosphorylated Op18/stathmin primarily at serine 25 in vitro [8].
  • In the delayed implantation pregnant rat model, uterine stathmin expression was low, but increased after implantation induced by administration of 17beta-estradiol to the progesterone-primed animal [9].
  • Stathmin is one of the major neural-enriched cytosolic phosphoproteins and a potential target of cyclic-AMP-dependent kinases [Jin L. W. et al. (1996) Neurobiol. Aging 17, 331-341; Leighton I. A. et al. (1993) Molec. Cell Biochem. 127/128, 151-156] [14].
  • In this review, the neuroprotective actions of testosterone on three different populations of injured rat peripheral motoneurons, i.e. facial (FMN), spinal (SMN) and pudendal (PMN), will be discussed [15].
  • We previously reported that when 32Pi-loaded rat parotid slices are incubated with the beta-adrenergic agonist isoproterenol, the level of a soluble 32P-labeled 17-kDa protein (pp17) decreases rapidly (Kanamori, T., and Hayakawa, T. (1982) Biochem. Int. 4, 517-523) [16].

Physical interactions of Stmn1


Enzymatic interactions of Stmn1

  • KIS produced in bacteria has an autophosphorylating activity and phosphorylates stathmin on serine residues [19].

Regulatory relationships of Stmn1


Other interactions of Stmn1

  • These results suggest that stathmin plays an essential role in anchorage-independent growth by cJun and may be a potential target for specific inhibitors for AP-1-dependent processes involved in carcinogenesis [7].
  • The pattern of expression of the RB3 transcript is very different from that of the three other members of the stathmin family [22].
  • Stathmin immunohistochemistry in adult rodent brain revealed prominent expression in neuroproliferative zones and neuronal migration pathways, a pattern that resembles the expression of doublecortin, which is implicated in neuronal migration [2].
  • SCG10 and stathmin expression in the olfactory receptor neurons was found to be regulated during embryonic and postnatal development and to correlate with neuronal maturation [23].
  • Accordingly, it is most likely that caveolin increased the polymer form of microtubule through the inhibition of a microtubule destabilizer, stathmin, suggesting a novel role of caveolin in regulating cellular network and trafficking [24].

Analytical, diagnostic and therapeutic context of Stmn1


  1. Expression of stathmin, a developmentally controlled cytoskeleton-regulating molecule, in demyelinating disorders. Liu, A., Stadelmann, C., Moscarello, M., Bruck, W., Sobel, A., Mastronardi, F.G., Casaccia-Bonnefil, P. J. Neurosci. (2005) [Pubmed]
  2. Proteomic and immunochemical characterization of a role for stathmin in adult neurogenesis. Jin, K., Mao, X.O., Cottrell, B., Schilling, B., Xie, L., Row, R.H., Sun, Y., Peel, A., Childs, J., Gendeh, G., Gibson, B.W., Greenberg, D.A. FASEB J. (2004) [Pubmed]
  3. Selective upregulation of RB3/stathmin4 by ciliary neurotrophic factor following optic nerve axotomy. Nakazawa, T., Morii, H., Tamai, M., Mori, N. Brain Res. (2005) [Pubmed]
  4. Gene expression profiling in the mammary gland of rats treated with 7,12-dimethylbenz[a]anthracene. Papaconstantinou, A.D., Shanmugam, I., Shan, L., Schroeder, I.S., Qiu, C., Yu, M., Snyderwine, E.G. Int. J. Cancer (2006) [Pubmed]
  5. Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. Ng, D.C., Lin, B.H., Lim, C.P., Huang, G., Zhang, T., Poli, V., Cao, X. J. Cell Biol. (2006) [Pubmed]
  6. The phosphoprotein stathmin is essential for nerve growth factor-stimulated differentiation. Di Paolo, G., Pellier, V., Catsicas, M., Antonsson, B., Catsicas, S., Grenningloh, G. J. Cell Biol. (1996) [Pubmed]
  7. Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth. Kinoshita, I., Leaner, V., Katabami, M., Manzano, R.G., Dent, P., Sabichi, A., Birrer, M.J. Oncogene (2003) [Pubmed]
  8. Identification of Op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade. Mizumura, K., Takeda, K., Hashimoto, S., Horie, T., Ichijo, H. J. Cell. Physiol. (2006) [Pubmed]
  9. Enhanced expression of uterine stathmin during the process of implantation and decidualization in rats. Tamura, K., Hara, T., Yoshie, M., Irie, S., Sobel, A., Kogo, H. Endocrinology (2003) [Pubmed]
  10. Neuronal activity induction of the stathmin-like gene RB3 in the rat hippocampus: possible role in neuronal plasticity. Beilharz, E.J., Zhukovsky, E., Lanahan, A.A., Worley, P.F., Nikolich, K., Goodman, L.J. J. Neurosci. (1998) [Pubmed]
  11. Stathmin family proteins display specific molecular and tubulin binding properties. Charbaut, E., Curmi, P.A., Ozon, S., Lachkar, S., Redeker, V., Sobel, A. J. Biol. Chem. (2001) [Pubmed]
  12. The SCG10-related gene family in the developing rat retina: persistent expression of SCLIP and stathmin in mature ganglion cell layer. Nakazawa, T., Nakano, I., Furuyama, T., Morii, H., Tamai, M., Mori, N. Brain Res. (2000) [Pubmed]
  13. Two separate motifs cooperate to target stathmin-related proteins to the Golgi complex. Charbaut, E., Chauvin, S., Enslen, H., Zamaroczy, S., Sobel, A. J. Cell. Sci. (2005) [Pubmed]
  14. Perforant path lesion induces up-regulation of stathmin messenger RNA, but not SCG10 messenger RNA, in the adult rat hippocampus. Bräuer, A.U., Savaskan, N.E., Plaschke, M., Ninnemann, O., Nitsch, R. Neuroscience (2001) [Pubmed]
  15. Neuroprotective effects of gonadal steroids on regenerating peripheral motoneurons. Jones, K.J., Brown, T.J., Damaser, M. Brain Res. Brain Res. Rev. (2001) [Pubmed]
  16. Identification of two 17-kDa rat parotid gland phosphoproteins, subjects for dephosphorylation upon beta-adrenergic stimulation, as destrin- and cofilin-like proteins. Kanamori, T., Hayakawa, T., Suzuki, M., Titani, K. J. Biol. Chem. (1995) [Pubmed]
  17. Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neuron-specific member of the SCG10 family, by its N-terminal domain. Nakao, C., Itoh, T.J., Hotani, H., Mori, N. J. Biol. Chem. (2004) [Pubmed]
  18. Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells. Kang, S.W., Shin, Y.J., Shim, Y.J., Jeong, S.Y., Park, I.S., Min, B.H. Exp. Cell Res. (2005) [Pubmed]
  19. KIS is a protein kinase with an RNA recognition motif. Maucuer, A., Ozon, S., Manceau, V., Gavet, O., Lawler, S., Curmi, P., Sobel, A. J. Biol. Chem. (1997) [Pubmed]
  20. Electrophoretic studies on the phosphorylation of stathmin and mitogen-activated protein kinases in neuronal cell death induced by oxidized very-low-density lipoprotein with apolipoprotein E. Yamashita, H., Nakamura, K., Arai, H., Furumoto, H., Fujimoto, M., Kashiwagi, S., Morimatsu, M. Electrophoresis (2002) [Pubmed]
  21. The cytosolic phosphoprotein stathmin is expressed in the olfactory system of the adult rat. Camoletto, P., Peretto, P., Bonfanti, L., Manceau, V., Sobel, A., Fasolo, A. Neuroreport (1997) [Pubmed]
  22. Differential, regional, and cellular expression of the stathmin family transcripts in the adult rat brain. Ozon, S., El Mestikawy, S., Sobel, A. J. Neurosci. Res. (1999) [Pubmed]
  23. Expression of SCG10 and stathmin proteins in the rat olfactory system during development and axonal regeneration. Pellier-Monnin, V., Astic, L., Bichet, S., Riederer, B.M., Grenningloh, G. J. Comp. Neurol. (2001) [Pubmed]
  24. Caveolin regulates microtubule polymerization in the vascular smooth muscle cells. Kawabe, J., Okumura, S., Nathanson, M.A., Hasebe, N., Ishikawa, Y. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  25. Differential localization of SCG10 and p19/stathmin messenger RNAs in adult rat brain indicates distinct roles for these growth-associated proteins. Himi, T., Okazaki, T., Wang, H., McNeill, T.H., Mori, N. Neuroscience (1994) [Pubmed]
  26. Induction of stathmin expression during liver regeneration. Koppel, J., Loyer, P., Maucuer, A., Rehák, P., Manceau, V., Guguen-Guillouzo, C., Sobel, A. FEBS Lett. (1993) [Pubmed]
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